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Posterior cerebellar resection and pain processing in the pediatric brain

小脑后切除术和小儿大脑的疼痛处理

基本信息

批准号：
8691155
负责人：
Eric Alan Moulton
金额：
$ 19.13万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8691155
关键词：
Adult Affect Affective Anesthesiology Anterior Area Aversive Stimulus Boston Brain Cancer Patient Cerebellar Neoplasms Cerebellum Child Childhood Clinical Clinical Research Cognition Cognitive Cognitive deficits Development Diagnostic Dimensions Doctor of Philosophy Environment Esthesia Excision Functional Imaging Functional Magnetic Resonance Imaging Goals Hospital Departments Human Insula of Reil Investigation Lead Limbic System Magnetic Resonance Imaging Medicine Mission Motor Neuromodulator Pain Patients Pediatric Hospitals Perception Perioperative Play Procedures Process Public Health Publishing Quality of life Recruitment Activity Reporting Rest Role Sensory Somatosensory Cortex Stimulus Stroke Testing Therapeutic Work base chronic pain cingulate cortex design experience improved interest neuroimaging novel novel strategies public health relevance relating to nervous system research study response theories white matter

项目摘要

DESCRIPTION (provided by applicant): This R21 application is designed to determine the impact of cerebellar damage on pain sensation and pain processing in the brain. Pain is a subjective experience comprised of sensory, affective, and cognitive dimensions. Human functional imaging studies investigating experimental and clinical pain consistently find cerebellar activation, though its functional implications are unclear. Initially thought to reflecta motor circuit response to pain, the characterization of cognitive and affective deficits following cerebellar damage in children and adults suggest a fundamental role in pain processing. We have also published work that suggests that the cerebellum may serve as a multimodal modulator of negative affect, a significant component in pain processing. However, as far as we know, a thorough investigation of changes in pain sensation following cerebellar tumor resection has never been reported. The hypothesis of this project is that the posterior cerebellum modulates affective brain circuits to down-regulate pain perception in response to noxious stimuli. The specific aims are (1) to define the consequences of cerebellar tumor resection on pain perception with sensory testing, and (2) define the consequences of resection on pain processing in the brain with functional magnetic resonance imaging. Boston Children's Hospital will provide an ideal clinical research environment to efficiently recruit patients, and to evaluat them with sensory testing and neuroimaging. The long-term goal is to identify the role of the cerebellum in pain processing.

描述（由申请人提供）：该 R21 应用程序旨在确定小脑损伤对大脑疼痛感觉和疼痛处理的影响。疼痛是一种主观体验，包括感觉、情感和认知维度。研究实验和临床疼痛的人类功能成像研究一致发现小脑激活，尽管其功能意义尚不清楚。最初认为反映了运动回路对疼痛的反应，儿童和成人小脑损伤后认知和情感缺陷的特征表明在疼痛处理中发挥着重要作用。我们还发表的研究表明，小脑可能充当负面情绪的多模式调节器，这是疼痛处理的重要组成部分。然而，据我们所知，尚未有关于小脑肿瘤切除术后痛觉变化的彻底研究的报道。该项目的假设是，后小脑调节情感脑回路，下调对有害刺激的疼痛感知。具体目标是（1）通过感觉测试确定小脑肿瘤切除对疼痛感知的影响，以及（2）通过功能磁共振成像确定切除对大脑疼痛处理的影响。波士顿儿童医院将提供理想的临床研究环境，以有效地招募患者，并通过感官测试和神经影像学对他们进行评估。长期目标是确定小脑在疼痛处理中的作用。