Periodontal Infections and Type 2 Diabetes Mellitus Risk

牙周感染和 2 型糖尿病风险

• 批准号: 8902549
• 负责人: Ryan T. Demmer
• 金额: $ 6.93万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8902549
• 关键词: Address; Age; Antibodies; Bacteria; Beta Cell; Blood Cells; Body Composition; Cardiovascular Diseases; Cell physiology; Cells; Chronic; Clinical; Data; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Enrollment; Ethnic Origin; Exposure to; Functional disorder; Future; Gender; Gene Expression; Glycosylated hemoglobin A; Health; Homeostasis; Impaired fasting glycaemia; Incidence; Infection; Infectious Agent; Inflammation; Inflammatory Response; Insulin; Insulin Resistance; Knowledge; Link; Lipids; Measures; Mediating; Mediator of activation protein; Methods; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pathology; Periodontal Diseases; Periodontal Infection; Physical activity; Population; Pregnancy Outcome; Process; Public Health; Reporting; Research; Research Design; Research Proposals; Risk; Risk Factors; Role; Scientific Advances and Accomplishments; Smoking; Source; Systemic disease; Testing; Woman; Working Women; aged; case control; cohort; design; diabetes risk; fasting glucose; fasting plasma glucose; follow-up; interest; men; pathogen; population based; time use; working men

Type 2 diabetes mellitus (diabetes) is a growing public health problem. Chronic infections have been suggested as a potential risk factor for diabetes and there is a known association between periodontal infections and diabetes. Although it is generally believed that periodontal infections are a consequence of existing diabetes, there is growing support for the hypothesis that periodontal infections might contribute tq diabetogenesis, although research on this topic is limited. The evidence supporting the role of periodontal infections as a risk factor for a number of other systemic diseases (i.e., cardiovascular disease and pregnancy outcomes) continues to grow and further supports the rationale for. the current research proposal. Furthermore, recent reports implicate inflammation as a strong risk factor for incident diabetes. Since the inflammatory response is a central aspect of periodontal pathology, it is of interest to explore whether or not inflammation might mediate the association between periodontal disease and diabetes, or simply be an underlying contributor to both disease processes. The current proposal aims to test the hypothesis that periodontal infection is an etiologic factor in the development of diabetes. Baseline exposure to known periodontal pathogens will be assessed to see if elevated infectious exposure is associated with accelerated progression of fasting glucose and insulin levels. This will be achieved using a longitudinal cohort design among n=300 participants in a population of men and women aged 25 - 55 years at baseline enrollment. The proposed design will carefully control for potential confounders such as baseline levels of fasting glucose, insulin, lipids, obesity, diet, age, smoking, ethnicity and gender.

2型糖尿病（糖尿病）是日益增长的公共卫生问题。慢性感染已被认为是糖尿病的潜在危险因素，并且牙周感染和糖尿病之间存在已知关联。尽管通常认为牙周感染是现有糖尿病的结果，但越来越多的支持牙周感染可能会导致TQ糖尿病发生，尽管对该主题的研究受到限制。支持牙周感染作为许多其他系统性疾病（即心血管疾病和妊娠结局）的危险因素的证据继续增长，并进一步支持基本原理。当前的研究建议。此外，最近的报道暗示炎症是出现糖尿病的强大危险因素。由于炎症反应是牙周病理学的一个核心方面，因此探索炎症是否可以介导牙周疾病与糖尿病之间的关联，或者只是为这两种疾病过程而成为基本贡献者。当前的建议旨在检验牙周感染是糖尿病发展的病因学因素的假设。将评估对已知牙周病原体的基线暴露，以查看感染性升高是否与禁食葡萄糖和胰岛素水平的加速进展有关。这将在基线入学时25-55岁的男女中的n = 300名参与者中使用纵向队列设计来实现这一目标。拟议的设计将仔细控制潜在的混杂因素，例如禁食葡萄糖，胰岛素，脂质，肥胖，饮食，年龄，吸烟，种族和性别的基线水平。