Capacity Building for Lifespan Focused Substance Use Disorder Research in Ukraine

描述（由申请人提供）：物质使用障碍（sud）是在生命周期的各个阶段对社会造成重大损失的慢性、复发性疾病。这些问题在乌克兰尤其令人关切，因为乌克兰的酒精使用率在世界上排名第五，到16岁时，其终生非法药物使用率已经达到21%（世卫组织，2011年）。与此同时，由于长期的政治动荡和有限的国家资源，解决这些问题的干预规划主要集中在慢性终末期障碍上，伴随的专业培训和成瘾科学也有类似的重点。尽管一小部分熟悉过去十年西方国家发展的研究人员对这种改变的观点表示赞赏，并一直在寻找引进这种观点的方法，但发育/病因学科学和由此衍生的干预规划都是缺失的。该项目将与来自该团队的两名全国知名医师科学家（医学博士/博士）合作，并借鉴过去10年在其他东欧国家成功开展的药物滥用研究基础设施发展项目的经验，在几个不同的特异性、持续时间和重点层面上实施一套药物滥用研究培训经验。内容目标是知识的传递

DESCRIPTION (provided by applicant): Substance use disorders (SUDs) are chronic, recurring disorders of major cost to society at all stages of the life cycle. They are of particula concern in Ukraine, whose rate of alcohol use is 5th highest in the world and whose lifetime rate of illicit drug use is already 21% by age 16 (WHO, 2011). At the same time, because of long periods of political turmoil and limited national resources, intervention programming to address these issues is primarily focused on chronic, end stage disorder, and concomitant professional training and addiction science have a similar focus. Both developmental/etiologic science and the intervention programming derivative from that are absent, although a small subset of researchers familiar with developments over the past decade in western countries have been appreciative of this changed perspective, and have been looking for ways to import it. Working in collaboration with two nationally visible physician scientists (MD/PhDs) from this cadre, and drawing on the experience gleaned from a successful program of substance abuse research infrastructure development in other Eastern European countries over the last 10 years, this project would implement a set of substance abuse research training experiences at several different levels of specificity, duration, and focus. The content goal is for transfer of knowledge pertaining to the developmental etiology of SUDs and implementation of intervention techniques that build upon that scientific base. In the latter years of the program, we would mentor and collaborate in design and pilot testing of an early screening and intervention program that ultimately will have the potential for national dissemination. The proposed program involves collaboration among faculty from 16 disciplines at the University of Michigan (UM), Department of Psychiatry (Addiction Research Center), at the Ukrainian Scientific Research Institute of Social, Forensic Psychiatry and Narcology (USRISFPN), and at the National University of Kyiv- Mohyla Academy (NUKMA). A set of interlocking training experiences at different levels of intensity and career status will include the following: (a) Yearly workshops (~ 35 attendees) held in various sites in Ukraine, for all levels of post-doctoral substance abuse scientists interested n the developmental psychopathology of SUD, research methodology, and SUD prevention and intervention strategies in non-clinical or community-based settings. (b) Year-long fellowships at UM, for 5 early-career post-doctoral fellows to learn more research methodology and work with mentors in areas of common interest, (c) Home-country research projects that these fellows develop while in the U.S., (d) 3 intermediate-term fellowships at UM for mid-career substance abuse researchers. (e) 3 short-term fellowships for senior research faculty to consult at UM and NIH about future program directions. (f) Creation of a Research/Intervention Program working group to develop a clinical trial on SUD screening and early intervention in targeted communities; and (g) Support of increased scientific collaboration between Ukrainian substance abuse researchers and other Eastern European researchers.