Capacity Building for Lifespan Focused Substance Use Disorder Research in Ukraine

描述（由申请人提供）：物质使用障碍（SUD）是在生命周期的各个阶段对社会造成重大损失的慢性复发性疾病。这些问题在乌克兰尤其令人关切，该国的酒精使用率在世界上排名第五，到16岁时，其终生非法药物使用率已经达到21%（世卫组织，2011年）。与此同时，由于长期的政治动荡和有限的国家资源，解决这些问题的干预方案主要集中在慢性、终末期障碍，随之而来的专业培训和成瘾科学也有类似的重点。发展/病因学科学和干预规划的衍生物是缺席，虽然一小部分研究人员熟悉的发展，在过去十年中在西方国家一直赞赏这种变化的观点，并一直在寻找方法来导入它.与两个国家知名的医生科学家合作（MD/PhD）从这个干部，该项目将借鉴过去10年来其他东欧国家药物滥用研究基础设施发展的成功方案所积累的经验，在具体性、持续时间和重点等几个不同层面上实施一套药物滥用研究培训经验。内容的目标是知识的转移 关于SUD的发育病因学和基于该科学基础的干预技术的实施。在该计划的后几年，我们将指导和合作设计和试点测试的早期筛查和干预计划，最终将有可能在全国范围内传播。 拟议的计划涉及来自密歇根大学（UM），精神病学系（成瘾研究中心），社会，法医精神病学和麻醉学乌克兰科学研究所（USRISFPN）和国立基辅大学-莫希拉学院（NUKMA）的16个学科的教师之间的合作。一套在不同强度和职业地位水平的连锁培训经验将包括以下内容：（a）在乌克兰不同地点举办的年度讲习班（约35名与会者），为对SUD的发展心理病理学感兴趣的各级博士后药物滥用科学家，研究方法，以及非临床或社区环境中的SUD预防和干预战略。(b)为期一年的奖学金在澳门大学，为5个早期职业博士后研究员学习更多的研究方法，并与导师在共同感兴趣的领域，（c）母国研究项目，这些研究员在美国发展，(d)3中期奖学金在UM为中期职业药物滥用研究人员。(e)3短期奖学金高级研究人员在UM和NIH咨询未来的计划方向。(f)设立一个研究/干预方案工作组，在目标社区开展一项关于未成年人吸毒筛查和早期干预的临床试验;以及（g）支持乌克兰药物滥用研究人员与其他东欧研究人员之间加强科学合作。

DESCRIPTION (provided by applicant): Substance use disorders (SUDs) are chronic, recurring disorders of major cost to society at all stages of the life cycle. They are of particula concern in Ukraine, whose rate of alcohol use is 5th highest in the world and whose lifetime rate of illicit drug use is already 21% by age 16 (WHO, 2011). At the same time, because of long periods of political turmoil and limited national resources, intervention programming to address these issues is primarily focused on chronic, end stage disorder, and concomitant professional training and addiction science have a similar focus. Both developmental/etiologic science and the intervention programming derivative from that are absent, although a small subset of researchers familiar with developments over the past decade in western countries have been appreciative of this changed perspective, and have been looking for ways to import it. Working in collaboration with two nationally visible physician scientists (MD/PhDs) from this cadre, and drawing on the experience gleaned from a successful program of substance abuse research infrastructure development in other Eastern European countries over the last 10 years, this project would implement a set of substance abuse research training experiences at several different levels of specificity, duration, and focus. The content goal is for transfer of knowledge pertaining to the developmental etiology of SUDs and implementation of intervention techniques that build upon that scientific base. In the latter years of the program, we would mentor and collaborate in design and pilot testing of an early screening and intervention program that ultimately will have the potential for national dissemination. The proposed program involves collaboration among faculty from 16 disciplines at the University of Michigan (UM), Department of Psychiatry (Addiction Research Center), at the Ukrainian Scientific Research Institute of Social, Forensic Psychiatry and Narcology (USRISFPN), and at the National University of Kyiv- Mohyla Academy (NUKMA). A set of interlocking training experiences at different levels of intensity and career status will include the following: (a) Yearly workshops (~ 35 attendees) held in various sites in Ukraine, for all levels of post-doctoral substance abuse scientists interested n the developmental psychopathology of SUD, research methodology, and SUD prevention and intervention strategies in non-clinical or community-based settings. (b) Year-long fellowships at UM, for 5 early-career post-doctoral fellows to learn more research methodology and work with mentors in areas of common interest, (c) Home-country research projects that these fellows develop while in the U.S., (d) 3 intermediate-term fellowships at UM for mid-career substance abuse researchers. (e) 3 short-term fellowships for senior research faculty to consult at UM and NIH about future program directions. (f) Creation of a Research/Intervention Program working group to develop a clinical trial on SUD screening and early intervention in targeted communities; and (g) Support of increased scientific collaboration between Ukrainian substance abuse researchers and other Eastern European researchers.