Capacity Building for Lifespan Focused Substance Use Disorder Research in Ukraine

乌克兰以寿命为中心的药物使用障碍研究能力建设

• 批准号: 8507820
• 负责人: ROBERT ALPERT ZUCKER
• 金额: $ 21.79万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-09 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8507820
• 关键词: 21 year old; Academy; Address; Alcohol consumption; Area; Chronic; Clinical Trials; Collaborations; Communities; Consult; Country; Development; Discipline; Disease; Drug usage; Early Intervention; Educational workshop; Etiology; European; Faculty; Fellowship; Forensic Psychiatry; Future; Glean; Goals; Home environment; Illicit Drugs; Intervention; Knowledge; Learning; Life Cycle Stages; Longevity; Mentors; Michigan; Physicians; Postdoctoral Fellow; Prevention strategy; Psychiatry; Psychopathology; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Science; Scientist; Site; Societies; Specificity; Staging; Substance Use Disorder; Substance abuse problem; Techniques; Testing; Time; Training; Ukraine; United States National Institutes of Health; Universities; Work; addiction; base; career; cost; design; disorder prevention; experience; infrastructure development; interest; intervention program; programs; screening; social; working group

DESCRIPTION (provided by applicant): Substance use disorders (SUDs) are chronic, recurring disorders of major cost to society at all stages of the life cycle. They are of particula concern in Ukraine, whose rate of alcohol use is 5th highest in the world and whose lifetime rate of illicit drug use is already 21% by age 16 (WHO, 2011). At the same time, because of long periods of political turmoil and limited national resources, intervention programming to address these issues is primarily focused on chronic, end stage disorder, and concomitant professional training and addiction science have a similar focus. Both developmental/etiologic science and the intervention programming derivative from that are absent, although a small subset of researchers familiar with developments over the past decade in western countries have been appreciative of this changed perspective, and have been looking for ways to import it. Working in collaboration with two nationally visible physician scientists (MD/PhDs) from this cadre, and drawing on the experience gleaned from a successful program of substance abuse research infrastructure development in other Eastern European countries over the last 10 years, this project would implement a set of substance abuse research training experiences at several different levels of specificity, duration, and focus. The content goal is for transfer of knowledge pertaining to the developmental etiology of SUDs and implementation of intervention techniques that build upon that scientific base. In the latter years of the program, we would mentor and collaborate in design and pilot testing of an early screening and intervention program that ultimately will have the potential for national dissemination. The proposed program involves collaboration among faculty from 16 disciplines at the University of Michigan (UM), Department of Psychiatry (Addiction Research Center), at the Ukrainian Scientific Research Institute of Social, Forensic Psychiatry and Narcology (USRISFPN), and at the National University of Kyiv- Mohyla Academy (NUKMA). A set of interlocking training experiences at different levels of intensity and career status will include the following: (a) Yearly workshops (~ 35 attendees) held in various sites in Ukraine, for all levels of post-doctoral substance abuse scientists interested n the developmental psychopathology of SUD, research methodology, and SUD prevention and intervention strategies in non-clinical or community-based settings. (b) Year-long fellowships at UM, for 5 early-career post-doctoral fellows to learn more research methodology and work with mentors in areas of common interest, (c) Home-country research projects that these fellows develop while in the U.S., (d) 3 intermediate-term fellowships at UM for mid-career substance abuse researchers. (e) 3 short-term fellowships for senior research faculty to consult at UM and NIH about future program directions. (f) Creation of a Research/Intervention Program working group to develop a clinical trial on SUD screening and early intervention in targeted communities; and (g) Support of increased scientific collaboration between Ukrainian substance abuse researchers and other Eastern European researchers.

描述（由申请人提供）：物质使用障碍 (SUD) 是一种慢性、反复发作的疾病，在生命周期的各个阶段都会给社会造成重大损失。他们在乌克兰尤其令人担忧，该国的饮酒率在世界上排名第五，并且到 16 岁时终生非法药物使用率已达到 21%（世界卫生组织，2011 年）。同时，由于长期的政治动荡和有限的国家资源，解决这些问题的干预计划主要集中于慢性、末期障碍，并且伴随的专业培训和成瘾科学也有类似的重点。尽管一小部分熟悉西方国家过去十年发展的研究人员对这种改变的观点表示赞赏，并一直在寻找导入它的方法，但发展/病因学和由此派生的干预规划均不存在。该项目与该骨干队伍中的两名全国知名医师科学家（医学博士/博士）合作，并借鉴过去 10 年来在其他东欧国家药物滥用研究基础设施开发成功项目中收集的经验，将在不同的特异性、持续时间和重点层面实施一套药物滥用研究培训经验。内容目标是知识转移 有关 SUD 的发展病因学以及建立在该科学基础上的干预技术的实施。在该计划的最后几年，我们将指导和合作设计和试点测试早期筛查和干预计划，最终将有可能在全国范围内传播。 拟议的项目涉及来自密歇根大学 (UM)、精神病学系（成瘾研究中心）、乌克兰社会、法医精神病学和麻醉学科学研究所 (USRISFPN) 以及基辅国立大学莫希拉学院 (NUKMA) 16 个学科的教师之间的合作。一系列不同强度和职业状态水平的环环相扣的培训经验将包括以下内容： (a) 每年在乌克兰不同地点举办研讨会（约 35 名参加者），面向对 SUD 发展精神病理学、研究方法以及非临床或社区环境中 SUD 预防和干预策略感兴趣的各级药物滥用博士后科学家。 (b) 为 5 名职业生涯早期的博士后研究员提供为期一年的 UM 奖学金，以学习更多研究方法并与导师在共同感兴趣的领域合作，(c) 这些研究员在美国期间开发的母国研究项目，(d) 为职业生涯中期的药物滥用研究人员提供 3 个 UM 中期奖学金。 (e) 3 个短期奖学金，供高级研究人员在 UM 和 NIH 咨询未来项目方向。 (f) 成立研究/干预方案工作组，以开展针对目标社区的 SUD 筛查和早期干预的临床试验； (g) 支持乌克兰药物滥用研究人员与其他东欧研究人员加强科学合作。