Antimicrobial Microbead Containing Topical Gel for Burn Wound Disinfection

用于烧伤创面消毒的含有抗菌微珠的外用凝胶

• 批准号: 8776654
• 负责人: Sanjiv Lalwani
• 金额: $ 30万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8776654
• 关键词: Achievement; Acids; Admission activity; Adverse effects; Area; Bacteria; Benchmarking; Biocompatible; Bolus Infusion; Budgets; Buffers; Burn Centers; Burn injury; Candida albicans; Chemistry; Collaborations; Development; Development Plans; Dextrans; Diffuse; Disinfection; Dose; Drug Formulations; Enterococcus faecalis; Epithelial; Family suidae; Fee-for-Service Plans; Gel; Glycolates; Goals; Gram-Negative Bacteria; Granulation Tissue; Healed; Health Care Costs; Health Personnel; Health care facility; Hospitalization; Hydration status; In Vitro; Infection; Ions; Klebsiella pneumonia bacterium; Laboratories; Leukocytes; Leukopenia; Liquid substance; Microspheres; Modeling; Morphology; NIH Program Announcements; National Institute of Allergy and Infectious Disease; Natural regeneration; Nitric Oxide; Nitrites; Nosocomial Infections; Organism; Patients; Performance; Phase; Polymers; Polysaccharides; Proteus mirabilis; Pseudomonas aeruginosa; Recovery; Research; Safety; Serine; Silver; Site; Small Business Innovation Research Grant; Staphylococcus aureus; Sterile coverings; Sulfadiazine; Surface; System; Technology; Temperature; Testing; Therapeutic; Thick; Time; Topical Antibiotic; Topical application; Universities; Virus; Water; Wound Healing; Wound Infection; antimicrobial; antimicrobial drug; base; biocompatible polymer; biodegradable polymer; cytotoxicity; design; dextran; functional group; fungus; healing; in vivo; medical schools; microorganism; novel; prevent; public health relevance; research and development; response; scaffold; screening; solid state; technology development; vector; wound; wound cleaning

DESCRIPTION (provided by applicant): In the U.S. there are more than 40,000 hospitalizations annually related to burn injury, with more than 75% of these admissions to the 127 U.S burn centers resulting in more than $10 billion in healthcare costs. Burn wounds may become infected through patient self infection from their own normal flora or by nosocomial infection between healthcare provider or facility and the patient. To prevent and/or treat these infections topical antimicrobial agents are applied at the wound site. The most commonly applied topical treatments are based on the release of silver ions through a compound (e.g., silver sulfadiazine) or dressing. Although silver can act as a potent antimicrobial, depending on the delivery vector cytotoxicity may result in leukopenia and impeded wound healing through inhibition of epithelial regeneration. Therefore a new broad spectrum antimicrobial topical material is proposed. The overall objective of this research effort is to demonstrate a new potent, broad spectrum, biocompatible, and biodegradable antimicrobial material for treating burn wound infections. Achievement of the following aims will demonstrate the feasibility of the proposed topical antimicrobial - (1) demonstrate release of antimicrobial agent from a full biocompatible and biodegradable substrate; (2) demonstrate broad spectrum antimicrobial function against multiple burn wound-related pathogenic microorganisms in vitro and in vivo; (3) demonstrate potential safety of material through in vitro cytotoxicity screening; and (4) benchmark antimicrobial function against commercially available topical treatments. In the Phase II follow on effort antimicrobial formulation will be optimized, dispensing mechanism will be refined and in vivo experimentation will be expanded. The final product is expected to be an easy-to- use and easy-to-apply topical gel.

描述（由申请人提供）：在美国，每年有超过40，000例与烧伤有关的住院治疗，其中超过75%的人进入美国127个烧伤中心，导致超过100亿美元的医疗费用。烧伤伤口可能通过患者自身正常植物群感染或通过医疗保健提供者或机构与患者之间的医院感染而感染。为了预防和/或治疗这些感染，在伤口部位应用局部抗微生物剂。最常用的局部治疗是基于银离子通过化合物（例如，银磺胺嘧啶）或敷料。尽管银可作为有效的抗微生物剂，但取决于递送载体，细胞毒性可导致白细胞减少症并通过抑制上皮再生而阻碍伤口愈合。因此，提出了一种新的广谱抗菌外用材料。这项研究工作的总体目标是证明一种新的有效的，广谱的，生物相容的，可生物降解的抗菌材料用于治疗烧伤伤口感染。实现以下目标将证明所提出的局部抗菌剂的可行性-（1）证明抗菌剂从完全生物相容性和生物可降解的基质中释放;（2）证明体外和体内对多种烧伤伤口相关病原微生物的广谱抗菌功能;（3）通过体外细胞毒性筛选证明材料的潜在安全性;和（4）相对于市售局部治疗的基准抗微生物功能。在第二阶段的后续努力中，将优化抗菌制剂，完善分配机制，并扩大体内实验。最终产品预计将是一种易于使用和易于应用的局部凝胶。