HISTOPATHOLOGY CORE

摘要 核心C组织病理学核心是PPG工作的宝贵成本效益资产，因为它 植入它为PPG研究者提供了广泛的组织学服务，包括改善 保持核心的最新技术水平。该中心提供的组织学服务包括 处理、石蜡包埋、切片、染色和免疫组织化学。核心人员也 协助研究者收集动物组织进行组织学研究。新服务已上线 因为它们已经可以在市场上买到。核心有一个激光捕获显微镜， 显微切割，最近升级，以支持免疫荧光检测。这已经被用于 项目三.核心还购买了一个组织微阵列仪。此外，核心还提供数字化 选定的组织学发现的显微照片，以计划研究者。在过去的几年里，核心的组织结构 所有研究人员都在不同程度上使用了这些服务-除了非人类的旧项目I 灵长类动物只以一种很小的方式利用了核心，因为灵长类动物中心有自己的 组织病理学实验室对于即将到来的PPG，所有三个项目都将使用核心服务。托马斯博士 监督该计划，并根据需要提供个人建议和帮助。詹德隆女士是一位杰出的 他是一位组织学家，每天与PPG团队的成员一起工作。她办事效率很高。她特别 擅长运用免疫组织学技术。允许PPG成员拥有他们的组织 不对他们的个别项目收取额外费用。这在经济上是可行的，因为我们的 OHSU Knight癌症研究所

Abstract Core C the histopathology core has been an invaluable cost effective asset to the work of the PPG since its inception. It has provided a wide variety of histological services to PPG investigators including improvements that maintain the state of the art status of the core. The histology services provided by the Core include tissue processing, paraffin embedding, sectioning, staining and immunohistochemistry. Core personnel have also assisted investigators in the collection of animal tissues for histologic studies. New services have come on-line as they have become commercially available. The Core has a laser capture microscope for tissue microdissection that was recently upgraded to support immunofluorescence detection. This has been used on Project III. The Core has also purchased a tissue microarrayer. In addition, the Core provides digital photomicrographs of selected histologic findings to program investigators. In past years, the Core's histology services have been used to a varying extent by all of the investigators - except for the old Project I in nonhuman primates which took advantage of the core in only a minor way because primate center has its own histology/pathology lab. For the upcoming PPG all three of the projects will use the core services. Dr. Thomas oversees the program and offers personal advice and assistance as needed. Ms. Gendron is an outstanding histologist who works day to day with members of the PPG team. She is highly effective. She is especially adept at getting immunohistology techniques to work. Members of the PPG are allowed to have their tissues processed at no additional charge to their individual projects. This is financially possible because of our partnership with the OHSU Knight Cancer Institute.