Biological Analysis Core

生物分析核心

• 批准号: 8659017
• 负责人: JUDY A. VAN DE WATER
• 金额: $ 12.15万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659017
• 关键词: Achievement; Address; Area; Biological; Biological Assay; Cells; Cellular Neurobiology; Charge; Consultations; Data; Discipline; Environmental Exposure; Equipment; Experimental Designs; Fragile X Syndrome; Funding; Goals; Heterogeneity; Immune; Immune system; Immunology; Institutes; Knowledge; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Molecular; Molecular Neurobiology; Molecular and Cellular Biology; Neurobiology; Neurons; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Services; Supervision; System; Testing; Training; Work; autism spectrum disorder; biobehavior; clinical risk; design; environmental toxicology; experience; immune function; intellectual and developmental disability; interest; member; neuron development; response

One goal of the UC Davis MIND Institute IDDRC is to more thoroughly address the biological complexity of intellectual and developmental disabilities (IDD), such as fragile X syndrome (FXS) and autism spectrum disorders (ASD). The overall objective of the Biological Analysis Core (BAC) is to facilitate an integrated experimental approach to the study of the molecular and cellular mechanisms of neuronal and immune function, including interactions between the two systems, in the context of IDD. This type of comprehensive core does not currently exist at the MIND Institute or on the UC Davis campus. The BAC is designed to advance and support research on emerging concepts regarding cellular and molecular mechanisms contributing to the risk and clinical heterogeneity of conditions associated with IDD, including variable response to therapy. Services provided will facilitate analyses of neuronal development, direct and indirect interactions between the neuronal and immune systems, and cellular and molecular biology. The BAC will also serve as a liaison to the vast array of resources at UC Davis for studying environmental exposures and extend the core's assays and expertise to testing such exposure effects on immune and neuronal cells for IDDRC projects. Recent achievements in these key areas by investigators included in the proposed IDDRC can now provide the infrastructure needed to advance our understanding of the biologic underpinnings of FXS, ASD, and other IDD conditions. This new core will be a unique resource for the MIND Institute IDDRC and the entire IDDRC network. The BAC is charged with providing core services that address components from each of the MIND Institute IDDRC central themes: Integrated Biobehavioral Characterization of IDD, Environmental Contributions to IDD, and Targeted Treatments for IDD. The BAC is designed to: 1) support the scientific agenda of the IDDRC; 2) provide services and training related to analysis in the areas of cellular and molecular neurobiology and Immunology; 3) increase access to cutting-edge resources in cellular and molecular neurobiology and immunology that will enhance the research of IDDRC investigators; 4) work with each of the IDDRC cores to support the integration and dissemination of services; and 5) work with the Administrative Core to integrate the BAC into the broader context of the UC Davis IDDRC and the national network of NlCHD-funded IDDRCs. The expertise of the BAC director, co-director, and core staff members includes extensive knowledge and experience in immunology, molecular and cellular neurobiology and environmental toxicology in the area of IDD. The key members of the BAC have previously worked together successfully to integrate seemingly disparate disciplines to better understand the neurobiology of ASD. We will develop these successful relationships into a state-of-the-art core to provide users with five tiers of service: 1) consultation in model selection and experimental design; 2) training of users on available equipment; 3) training and supervision in conducting assays of interest where applicable; 4) provision of a battery of assays conducted by core staff; and 5) tailored sets of analyses conducted by core staff. Combinations of service can be designed to match user needs. Assistance with data interpretation will be provided as needed for each tier.

加州大学戴维斯分校智力研究所IDDRC的一个目标是更彻底地解决生物学的复杂性， 智力和发育障碍（IDD），如脆性X综合征（FXS）和自闭症谱系 自闭症（ASD）。生物分析核心（BAC）的总体目标是促进综合 神经元和免疫的分子和细胞机制研究的实验方法 功能，包括两个系统之间的相互作用，在IDD的背景下。这种类型的 综合核心目前不存在于MIND研究所或加州大学戴维斯分校校园。BAC是 旨在推进和支持有关细胞和分子的新兴概念的研究 导致IDD相关疾病风险和临床异质性的机制，包括 对治疗的不同反应。所提供的服务将有助于分析神经元的发育， 神经元和免疫系统之间的间接相互作用，以及细胞和分子生物学。背衬 也将作为加州大学戴维斯分校研究环境暴露的大量资源的联络人 并扩展核心的分析和专业知识，以测试这种暴露对免疫和神经细胞的影响， IDDRC项目。列入拟议的非洲荒漠化问题国际会议的调查人员最近在这些关键领域取得的成就 现在可以提供所需的基础设施，以促进我们对FXS生物基础的理解， ASD和其他IDD条件。这个新的核心将是一个独特的资源，为智力研究所IDDRC和 整个IDDRC网络。 BAC负责提供核心服务，解决每个MIND IDDRC中心主题：IDD的综合生物行为特征，环境贡献 和针对性治疗IDD。生物咨询委员会的目的是：1）支持科学议程 IDDRC; 2）提供与细胞和分子神经生物学领域分析相关的服务和培训 3）增加获得细胞和分子神经生物学前沿资源的机会， 免疫学，这将加强IDDRC研究人员的研究; 4）与每个IDDRC核心合作， 支持服务的整合和传播; 5）与行政核心合作， BAC纳入加州大学戴维斯分校IDDRC和NlCHD资助的IDDRC国家网络的更广泛背景。 BAC董事、联席董事和核心工作人员的专业知识包括广泛的知识和 在免疫学、分子和细胞神经生物学以及环境毒理学方面的经验， IDD。BAC的主要成员以前曾成功地合作， 不同的学科，以更好地了解ASD的神经生物学。我们将开发这些成功的 以客户关系为核心，为用户提供五个层次的服务：1）咨询模式 选择和实验设计; 2）培训用户使用现有设备; 3）培训和监督 在适用的情况下进行感兴趣的分析; 4）提供由核心工作人员进行的一系列分析;以及 5)由核心工作人员进行量身定制的分析。可以设计服务组合以匹配用户 需求将根据需要为每一级提供数据解释方面的援助。