Biological Analysis Core

生物分析核心

• 批准号: 8659017
• 负责人: JUDY A. VAN DE WATER
• 金额: $ 12.15万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659017
• 关键词: Achievement; Address; Area; Biological; Biological Assay; Cells; Cellular Neurobiology; Charge; Consultations; Data; Discipline; Environmental Exposure; Equipment; Experimental Designs; Fragile X Syndrome; Funding; Goals; Heterogeneity; Immune; Immune system; Immunology; Institutes; Knowledge; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Molecular; Molecular Neurobiology; Molecular and Cellular Biology; Neurobiology; Neurons; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Services; Supervision; System; Testing; Training; Work; autism spectrum disorder; biobehavior; clinical risk; design; environmental toxicology; experience; immune function; intellectual and developmental disability; interest; member; neuron development; response

One goal of the UC Davis MIND Institute IDDRC is to more thoroughly address the biological complexity of intellectual and developmental disabilities (IDD), such as fragile X syndrome (FXS) and autism spectrum disorders (ASD). The overall objective of the Biological Analysis Core (BAC) is to facilitate an integrated experimental approach to the study of the molecular and cellular mechanisms of neuronal and immune function, including interactions between the two systems, in the context of IDD. This type of comprehensive core does not currently exist at the MIND Institute or on the UC Davis campus. The BAC is designed to advance and support research on emerging concepts regarding cellular and molecular mechanisms contributing to the risk and clinical heterogeneity of conditions associated with IDD, including variable response to therapy. Services provided will facilitate analyses of neuronal development, direct and indirect interactions between the neuronal and immune systems, and cellular and molecular biology. The BAC will also serve as a liaison to the vast array of resources at UC Davis for studying environmental exposures and extend the core's assays and expertise to testing such exposure effects on immune and neuronal cells for IDDRC projects. Recent achievements in these key areas by investigators included in the proposed IDDRC can now provide the infrastructure needed to advance our understanding of the biologic underpinnings of FXS, ASD, and other IDD conditions. This new core will be a unique resource for the MIND Institute IDDRC and the entire IDDRC network. The BAC is charged with providing core services that address components from each of the MIND Institute IDDRC central themes: Integrated Biobehavioral Characterization of IDD, Environmental Contributions to IDD, and Targeted Treatments for IDD. The BAC is designed to: 1) support the scientific agenda of the IDDRC; 2) provide services and training related to analysis in the areas of cellular and molecular neurobiology and Immunology; 3) increase access to cutting-edge resources in cellular and molecular neurobiology and immunology that will enhance the research of IDDRC investigators; 4) work with each of the IDDRC cores to support the integration and dissemination of services; and 5) work with the Administrative Core to integrate the BAC into the broader context of the UC Davis IDDRC and the national network of NlCHD-funded IDDRCs. The expertise of the BAC director, co-director, and core staff members includes extensive knowledge and experience in immunology, molecular and cellular neurobiology and environmental toxicology in the area of IDD. The key members of the BAC have previously worked together successfully to integrate seemingly disparate disciplines to better understand the neurobiology of ASD. We will develop these successful relationships into a state-of-the-art core to provide users with five tiers of service: 1) consultation in model selection and experimental design; 2) training of users on available equipment; 3) training and supervision in conducting assays of interest where applicable; 4) provision of a battery of assays conducted by core staff; and 5) tailored sets of analyses conducted by core staff. Combinations of service can be designed to match user needs. Assistance with data interpretation will be provided as needed for each tier.

加州大学戴维斯分校心理研究所IDDRC的目标之一是更彻底地解决 智力和发育障碍(IDD)，如脆性X综合征(FXS)和自闭症 精神障碍(ASD)。生物分析核心(BAC)的总体目标是促进 研究神经和免疫分子和细胞机制的实验方法 在缺水的情况下，包括两个系统之间的相互作用。这种类型的 心智研究所或加州大学戴维斯分校目前还没有全面的核心课程。BAC是 旨在促进和支持关于细胞和分子的新兴概念的研究 导致IDD相关疾病的风险和临床异质性的机制包括 对治疗的反应各不相同。提供的服务将促进对神经元发育的分析，直接和 神经元和免疫系统之间的间接相互作用，以及细胞和分子生物学。BAC 还将作为加州大学戴维斯分校研究环境暴露的大量资源的联络人 并将核心的分析和专业知识扩展到测试这种暴露对免疫和神经细胞的影响 国际发展研究中心的项目。拟议的国际发展和发展中心所包括的调查员在这些关键领域取得的最新成就 现在可以提供所需的基础设施，以促进我们对FXS生物学基础的理解， ASD，以及其他IDD情况。这一新的核心将成为思维研究所IDDRC和 整个IDDRC网络。 BAC负责提供核心服务，解决每个头脑中的组件 IDDRC研究所的中心主题：IDD的综合生物行为特征，环境贡献 到IDD，以及针对IDD的靶向治疗。BAC的设计目的是：1)支持科学议程 国际发展研究中心；2)在细胞和分子神经生物学领域提供与分析有关的服务和培训 和免疫学；3)增加获得细胞和分子神经生物学和 将加强IDDRC调查人员研究的免疫学；4)与IDDRC的每个核心合作，以 支持服务的整合和传播；以及5)与行政核心合作，整合 在加州大学戴维斯分校国际发展和发展中心以及由非传染性疾病国家资助的国际发展和发展中心的国家网络的更广泛的背景下，BAC被纳入其中。 BAC董事、联席董事和核心员工的专业知识包括广泛的知识和 在免疫学、分子和细胞神经生物学以及环境毒理学领域的经验 IDD。BAC的关键成员此前曾成功地合作，似乎整合了 不同的学科，以更好地了解ASD的神经生物学。我们将成功地发展这些 关系成为最先进的核心，为用户提供五层服务：1)模型中的咨询 选择和实验设计；2)使用现有设备对用户进行培训；3)培训和监督 在适用的情况下进行感兴趣的化验；4)提供由核心工作人员进行的一系列化验；以及 5)由核心员工进行的量身定制的分析。可以设计服务组合以匹配用户 需要。如有需要，将为每一层提供数据解释方面的协助。