Core C. Biological and Molecular Analysis Core

核心 C. 生物和分子分析核心

• 批准号: 10682415
• 负责人: JUDY A. VAN DE WATER
• 金额: $ 19.83万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682415
• 关键词: Acceleration; Achievement; Address; Area; Autoimmune Diseases; Behavioral; Biological; Biological Assay; Biology; Brain; California; Cell Surface Receptors; Communicable Diseases; Constitution; Constitutional; Core Facility; Development; Doctor of Philosophy; Down Syndrome; Education; Educational workshop; Ensure; Environmental Risk Factor; Fragile X Syndrome; Functional disorder; Funding; Genes; Genome; Genomics; Goals; Image; Immune; Immune system; Immunologics; Immunology; Individual; Information Systems; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Knowledge; Malignant Neoplasms; Mentors; Methodology; Methods; Molecular; Molecular Analysis; Mus; Nervous System; Neurodevelopmental Disability; Neurologic; Play; Pneumonia; Positioning Attribute; Procedures; Protocols documentation; Research; Research Personnel; Resources; Risk; Role; Series; Services; Signal Pathway; Students; System; Systems Development; Technology; Training; Universities; Water; autism spectrum disorder; cellular imaging; clinical heterogeneity; comorbidity; design; efficacious treatment; epigenomics; genetic risk factor; individualized medicine; interdisciplinary approach; interest; molecular imaging; neuroimmunology; programs; regenerative; research study; response; senior faculty; stem cells

PROJECT SUMMARY – BIOLOGICAL AND MOLECULAR ANALYSIS CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The Biological and Molecular Analysis Core (BMAC) is designed to facilitate studies at the cellular and molecular levels investigating the mechanisms by which genetic and environmental risk factors interact to influence brain and immune system development and function in the context of IDD. The BMAC will achieve this goal by addressing three specific aims. Aim 1 is to provide cutting- edge resources and expertise for analyses in neuroimmunology, cellular and molecular imaging, and epigenomics and genomics within the context of IDD research. This aim will be addressed through a tiered approach to services that ranges from full-service support to training of core users to enable independent use of core facilities and resources to access to core facilities and resources for individuals with a strong working knowledge of the technology of interest. The Core will also provide liaison support for researchers with our partner UC Davis cores, including the Genome Center, the Center for Molecular and Genomic Imaging (CMGI), the Mouse Biology Program (MBP), and the Institute for Regenerative Cures (IRC) Stem Cell Core. Aim 2 is to provide education and mentoring at all levels from student to staff to senior faculty in the methods and concepts of immunology, cellular and molecular imaging, and genomics and epigenomics. This aim will be addressed by working with IDDRC investigators to plan their projects and ensure they understand the potential for addressing their aims with the full range of assays and analyses available from the Core, training IDDRC project staff and investigators in the use of selected technologies available in the Core, and offering workshops and seminars illustrating the findings that emerge from the services of the Core. Aim 3 is to support the MIND Institute IDDRC cores and the broader IDDRC network. This aim will be addressed by developing procedures, protocols, and data systems that are informed by, and inform, the other MIND Institute IDDRC cores, and by providing technical and intellectual expertise to support and expand the numerous biological and molecular IDD research studies within the MIND Institute IDDRC and, when appropriate, the entire IDDRC network. The constitution of the BMAC reflects the unique expertise and interdisciplinary approaches for studying IDD at the UC Davis MIND Institute IDDRC, including state-of-the-art methodology in immunology, cellular and molecular imaging, epigenomics, and gene X environmental interactions. The Director of the BMAC is Judy Van de Water, PhD.

项目摘要 – 生物和分子分析核心 本申请寻求资金以继续 MIND 研究所智力与发展 加州大学戴维斯分校残疾人研究中心 (IDDRC)。 IDDRC 于 2013 年启动 是网络中 14 个 IDDRC 中最新的一个。生物和分子分析核心 (BMAC) 是 旨在促进细胞和分子水平的研究，调查遗传的机制 和环境风险因素相互作用，影响大脑和免疫系统的发育和功能 IDD 的背景。 BMAC 将通过实现三个具体目标来实现这一目标。目标 1 是提供切割- 用于神经免疫学、细胞和分子成像分析的边缘资源和专业知识，以及 IDD 研究背景下的表观基因组学和基因组学。这一目标将通过分层的方式来实现 服务方式涵盖从全方位服务支持到核心用户培训以实现独立使用 核心设施和资源，为具有强大工作能力的个人提供核心设施和资源 对感兴趣的技术的了解。核心还将为研究人员与我们的研究人员提供联络支持 合作伙伴加州大学戴维斯分校核心，包括基因组中心、分子和基因组成像中心 (CMGI)、 小鼠生物学计划（MBP）和再生治疗研究所（IRC）干细胞核心。目标 2 是 为从学生到员工再到高级教师的各个级别提供方法和概念方面的教育和指导 免疫学、细胞和分子成像、基因组学和表观基因组学。这一目标将通过 与 IDDRC 调查人员合作规划他们的项目并确保他们了解解决问题的潜力 他们的目标是通过核心提供的全方位检测和分析，培训 IDDRC 项目人员和 研究人员使用核心中可用的选定技术，并提供讲习班和研讨会 说明从核心服务中得出的结论。目标 3 是支持 MIND Institute IDDRC 核心和更广泛的 IDDRC 网络。这一目标将通过制定程序、协议和 数据系统由其他 MIND Institute IDDRC 核心提供信息，并提供技术支持 和知识专长，以支持和扩展众多的生物和分子 IDD 研究 在 MIND 研究所 IDDRC 内，并在适当时在整个 IDDRC 网络内。 BMAC的章程 反映了加州大学戴维斯分校 MIND 研究所研究 IDD 的独特专业知识和跨学科方法 IDDRC，包括免疫学、细胞和分子成像、表观基因组学和 基因 X 环境相互作用。 BMAC 的主任是 Judy Van de Water 博士。