Core C. Biological and Molecular Analysis Core

项目概要-生物和分子分析核心 本申请寻求资金，以继续智力和发展研究所 残疾人研究中心（IDDRC）在加州大学戴维斯分校。IDDRC于2013年启动 并且是网络中14个IDDRC中最新的一个。生物和分子分析核心（BMAC） 旨在促进在细胞和分子水平上的研究，调查遗传学的机制， 和环境风险因素相互作用，影响大脑和免疫系统的发育和功能， IDD的背景。BMAC将通过解决三个具体目标来实现这一目标。目标1是提供切割- 神经免疫学、细胞和分子成像分析的边缘资源和专业知识，以及 表观基因组学和缺碘症研究背景下的基因组学。这一目标将通过一个分层次的 服务方法包括从全方位服务支持到核心用户培训，以实现独立使用 核心设施和资源，以获得核心设施和资源的个人具有较强的工作能力， 了解感兴趣的技术。核心还将为研究人员提供联络支持， 合作伙伴加州大学戴维斯分校的核心，包括基因组中心，分子和基因组成像中心（CMGI）， 小鼠生物学计划（MBP）和再生治疗研究所（IRC）干细胞核心。目标二是 在方法和概念方面提供从学生到员工到高级教师的各级教育和指导 免疫学，细胞和分子成像，基因组学和表观基因组学。这一目标将通过以下方式实现： 与IDDRC调查人员合作，规划他们的项目，并确保他们了解解决 利用核心项目提供的各种化验和分析，培训非洲药物滥用防治中心项目工作人员， 研究人员使用核心中现有的选定技术，并举办讲习班和研讨会 说明核心服务中出现的调查结果。目标3是支持MIND Institute IDDRC 核心和更广泛的IDDRC网络。这一目标将通过制定程序、协议和 由其他MIND研究所IDDRC核心通知并通知其他MIND研究所IDDRC核心的数据系统，并通过提供技术支持， 和知识专长，以支持和扩大众多的生物和分子碘缺乏病研究 在MIND Institute IDDRC内，以及在适当的时候，整个IDDRC网络。BMAC的组成 反映了在加州大学戴维斯分校MIND研究所研究IDD的独特专业知识和跨学科方法 IDDRC，包括免疫学、细胞和分子成像、表观基因组学和 基因X与环境的相互作用BMAC主任是Judy货车de Water博士。

PROJECT SUMMARY – BIOLOGICAL AND MOLECULAR ANALYSIS CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The Biological and Molecular Analysis Core (BMAC) is designed to facilitate studies at the cellular and molecular levels investigating the mechanisms by which genetic and environmental risk factors interact to influence brain and immune system development and function in the context of IDD. The BMAC will achieve this goal by addressing three specific aims. Aim 1 is to provide cutting- edge resources and expertise for analyses in neuroimmunology, cellular and molecular imaging, and epigenomics and genomics within the context of IDD research. This aim will be addressed through a tiered approach to services that ranges from full-service support to training of core users to enable independent use of core facilities and resources to access to core facilities and resources for individuals with a strong working knowledge of the technology of interest. The Core will also provide liaison support for researchers with our partner UC Davis cores, including the Genome Center, the Center for Molecular and Genomic Imaging (CMGI), the Mouse Biology Program (MBP), and the Institute for Regenerative Cures (IRC) Stem Cell Core. Aim 2 is to provide education and mentoring at all levels from student to staff to senior faculty in the methods and concepts of immunology, cellular and molecular imaging, and genomics and epigenomics. This aim will be addressed by working with IDDRC investigators to plan their projects and ensure they understand the potential for addressing their aims with the full range of assays and analyses available from the Core, training IDDRC project staff and investigators in the use of selected technologies available in the Core, and offering workshops and seminars illustrating the findings that emerge from the services of the Core. Aim 3 is to support the MIND Institute IDDRC cores and the broader IDDRC network. This aim will be addressed by developing procedures, protocols, and data systems that are informed by, and inform, the other MIND Institute IDDRC cores, and by providing technical and intellectual expertise to support and expand the numerous biological and molecular IDD research studies within the MIND Institute IDDRC and, when appropriate, the entire IDDRC network. The constitution of the BMAC reflects the unique expertise and interdisciplinary approaches for studying IDD at the UC Davis MIND Institute IDDRC, including state-of-the-art methodology in immunology, cellular and molecular imaging, epigenomics, and gene X environmental interactions. The Director of the BMAC is Judy Van de Water, PhD.