Evaluation of Noise Reduction in Acoustic Radiation Force Elastography

声辐射力弹性成像降噪评价

• 批准号: 8427087
• 负责人: Stephen A McAleavey
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8427087
• 关键词: Acoustics; Area; Controlled Study; Data; Development; Diagnostic; Disease; Evaluation; Fibrosis; Frequencies; Generations; Goals; Heterogeneity; Human; Image; Imaging technology; Immune; Knowledge; Literature; Liver; Liver Fibrosis; Location; Measurement; Measures; Methods; Modeling; Motion; Noise; Phase; Physiological; Publishing; Radiation; Rattus; Resolution; Rodent; Sampling; Shapes; Source; Techniques; Testing; Time; Tissues; Ultrasonics; Ultrasonography; Work; absorption; attenuation; elastography; imaging modality; in vivo; interest; public health relevance; research study

DESCRIPTION (provided by applicant): Ultrasonic tracking of shear wave propagation in tissue is a key step in the estimation of tissue shear modulus in several methods of ultrasound elastography. Tracking of shear wave propagation at multiple locations is used to estimate shear wave velocity or phase. We have shown that ultrasound speckle can contribute a significant variance to these measurements, as a consequence of the independent scatterer sets at each location. Preliminary data indicates that techniques which rely on tracking at a single spatial location are relatively immune to this noise source and hold the potential for highe spatial and modulus resolution. Minimizing speckle noise reduces the need for spatial averaging and allows shear modulus or velocity to be estimated with better precision over a smaller sample volume. We hypothesize that, for a given spatial resolution requirement, methods that track at a single location (STL) produce lower modulus estimates than those that track at multiple locations (MTL). We propose experiments to compare the variance of modulus estimates obtained by STL and MTL under matched conditions of SNR, ultrasound parameters, and shear modulus. Measurements will be performed in tissue mimicking phantoms and in a rat model of liver fibrosis to establish the magnitude of noise reduction under in vivo conditions of increasing tissue heterogeneity.

描述（由申请人提供）：组织中剪切波传播的超声跟踪是几种超声弹性成像方法中估计组织剪切模量的关键步骤。在多个位置处的剪切波传播的跟踪用于估计剪切波速度或相位。我们已经表明，超声散斑可以贡献一个显着的变化，这些测量，作为独立的散射体集在每个位置的结果。初步数据表明，依赖于跟踪在一个单一的空间位置的技术是相对免疫的这种噪声源，并保持高的空间和模量分辨率的潜力。最小化散斑噪声减少了对空间平均的需要，并且允许在较小的样本体积上以更好的精度估计剪切模量或速度。我们假设，对于一个给定的空间分辨率的要求，在一个单一的位置（STL）跟踪的方法比那些在多个位置（MTL）跟踪产生较低的模量估计。我们提出的实验比较的方差的模量估计STL和MTL的SNR，超声参数和剪切模量的匹配条件下获得。将在组织模拟体模和肝纤维化大鼠模型中进行测量，以确定在增加组织异质性的体内条件下的降噪幅度。