Shear Wave Reciprocity for Breast Imaging

乳房成像的剪切波互易性

• 批准号: 10722721
• 负责人: Stephen A McAleavey
• 金额: $ 19.25万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-07 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10722721
• 关键词: Acoustics; Area; Benign; Biopsy; Breast Microcalcification; Breast biopsy; Categories; Classification; Computer Models; Data; Descriptor; Development; Diagnosis; Diagnostic; Distal; Elasticity; Equipment; Focused Ultrasound; Geometry; Goals; Human; Image; Lesion; Location; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Ultrasonography; Maps; Mastectomy; Measurement; Measures; Mechanics; Methods; Modulus; Morphologic artifacts; Parameter Estimation; Patients; Performance; Physicians; Predictive Value; Property; Radiation; Research; Resolution; Shapes; Source; Speed; System; Testing; Tissue Sample; Tissue imaging; Tissues; Ultrasonics; Ultrasonography; Variant; Woman; absorption; acoustic imaging; attenuation; breast imaging; breast lesion; contrast imaging; design; elastography; electric impedance; imaging system; improved; in vivo; malignant breast neoplasm; parametric imaging; simulation; sound; success; transmission process; ultrasound

Abstract: We propose a new ultrasound image formation method, which we call shear-wave reciprocity imaging (SRI), to produce images based on the sound speed and attenuation of tissue. These acoustic properties carry important diagnostic information but are not revealed in conventional B-mode images except as artifacts. For example, in breast imaging the “posterior features” (shadowing/enhancement) BiRADS descriptor depends on these properties. In contrast to conventional B-mode imaging that produces speckle images of variations in tissue acoustic impedance, we propose SRI as a method for speckle-free imaging of an attenuation/sound speed parameter. SRI images are complementary to both B-mode and elastography images yet are produced using the same backscatter imaging geometry as conventional ultrasound. SRI relies on the principle of mechanical reciprocity to measure local variations in acoustic radiation force, which relate to attenuation and sound speed. While using acoustic radiation force impulses similar to ARFI imaging, SRI is designed to be insensitive to elastic properties and to specifically image the attenuation/sound speed parameter. The aims of this project are to implement SRI on a linear-array imaging system, characterize its sensitivity and resolution through in vivo measurements prior to biopsy, and validate SRI in ex vivo breast tissue from mastectomy. We expect that the additional information provided by SRI will ultimately improve lesion categorization and reduce the number of biopsies required by replacing qualitative estimates of lesion attenuation from B-mode shadowing with parametric acoustic images.

抽象的： 我们提出了一种新的超声图像形成方法，称为剪切波互易成像（SRI） 根据声速和组织的衰减产生图像。这些声学特性携带 重要的诊断信息，但在传统 B 型图像中不会显示，除非作为伪影。为了 例如，在乳腺成像中，“后部特征”（阴影/增强）BiRADS 描述符取决于 这些属性。与传统的 B 模式成像相比，传统的 B 模式成像产生的散斑图像的变化 组织声阻抗，我们提出 SRI 作为一种衰减/声音无散斑成像的方法 速度参数。 SRI 图像是 B 模式和弹性成像图像的补充 使用与传统超声相同的反向散射成像几何结构。 SRI 的原则是 机械互易性来测量声辐射力的局部变化，这与衰减和 声速。在使用类似于 ARFI 成像的声辐射力脉冲时，SRI 被设计为 对弹性特性不敏感，并且可以对衰减/声速参数进行专门成像。的目标 该项目将在线性阵列成像系统上实施 SRI，表征其灵敏度和分辨率 通过活检前的体内测量，并验证来自乳房切除术的离体乳腺组织中的 SRI。我们 预计 SRI 提供的附加信息最终将改善病变分类并减少 替换 B 模式病变衰减定性估计所需的活检数量 参数化声学图像的阴影。