Computer-Assisted functional neurosurgery

计算机辅助功能神经外科

• 批准号: 8470164
• 负责人: BENOIT M. DAWANT
• 金额: $ 53.72万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8470164
• 关键词: Address; Adverse effects; Atlases; Brain; Clinical; Complex; Computer Assisted; Consumption; Data; Databases; Deep Brain Stimulation; Detection; Devices; Diffusion Magnetic Resonance Imaging; Electrodes; Electrophysiology (science); Engineering; Essential Tremor; Goals; Image; Indium; Individual; Lead; Manufacturer Name; Measurement; Methods; Modeling; Movement Disorders; Neurologist; Neurology; Neurosurgeon; Operative Surgical Procedures; Parkinson Disease; Patient Selection; Patients; Phase; Physiological; Postoperative Period; Procedures; Process; Scientist; Shapes; Site; Structure; Symptoms; System; Techniques; Testing; Time; Visit; Work; awake; clinical research site; deep brain stimulator; electric field; experience; imaging modality; implantation; improved; interest; neurosurgery; point of care; programs; public health relevance; repository; symposium

DESCRIPTION (provided by applicant): Deep Brain Stimulation procedures used to treat movement disorders are complex. Patient selection is done in conferences involving neurosurgeons, neurologists, and physical therapists. Surgical placement of electrodes is frequently challenging because targets of interest are absent or poorly visible with current imaging modalities, or because targets move due to intra-operative brain shift. It is a lengthy process performed typically in awake patients that requires expertise in neurology, electrophysiology, and functional neurosurgery. The post-surgical programming of the stimulator is an equally challenging and time consuming task, requiring a choice from among 4000 possible parameter combinations, usually arrived at through an iterative process spanning several visits to the neurologist. Building on our accomplishments over the last four years, the goals of this project are to: (1) automate as much as possible each step in this process; (2) create an integrated system that will transform the overall procedure from a process in which information must be communicated among the many actors to one in which all information will be available at the time and point of care, and tailored to the clinical task being performed; (3) field and test this system at Vanderbilt and at other sites and collaborate with these sites to establish one central repository for DBS that can be used by practitioners around the world; and (4) work with industrial partners to disseminate the system.

描述（由申请人提供）：用于治疗运动障碍的深部脑刺激程序很复杂。患者的选择是在神经外科医生、神经科医生和物理治疗师参加的会议上完成的。电极的手术放置通常具有挑战性，因为在当前的成像模式下，感兴趣的目标不存在或很难看到，或者因为目标由于术中大脑移位而移动。这是一个漫长的过程，通常在清醒的患者中进行，需要神经病学、电生理学和功能神经外科方面的专业知识。刺激器的术后编程同样是一项具有挑战性和耗时的任务，需要从 4000 种可能的参数组合中进行选择，这些组合通常是通过多次拜访神经科医生的迭代过程得出的。 基于我们过去四年取得的成就，该项目的目标是：(1) 尽可能自动化该流程中的每个步骤； (2) 创建一个集成系统，将整个程序从必须在众多参与者之间沟通信息的过程转变为所有信息在护理时间和护理点均可获得的过程，并根据正在执行的临床任务进行定制； (3) 在范德比尔特和其他地点对该系统进行现场测试，并与这些地点合作，为 DBS 建立一个可供世界各地从业者使用的中央存储库； (4) 与行业合作伙伴合作推广该系统。

项目成果

Formulating spatially varying performance in the statistical fusion framework.

• DOI: 10.1109/tmi.2012.2190992
• 发表时间: 2012-06
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Asman AJ;Landman BA
• 通讯作者: Landman BA

Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses.

• DOI: 10.1016/j.neuropsychologia.2017.02.016
• 发表时间: 2017-05
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: van Wouwe NC;Pallavaram S;Phibbs FT;Martinez-Ramirez D;Neimat JS;Dawant BM;D'Haese PF;Kanoff KE;van den Wildenberg WPM;Okun MS;Wylie SA
• 通讯作者: Wylie SA

Effect of MR distortion on targeting for deep-brain stimulation.

• DOI: 10.1109/tbme.2010.2043675
• 发表时间: 2010-07
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Balachandran R;Welch EB;Dawant BM;Fitzpatrick JM
• 通讯作者: Fitzpatrick JM

Multi-Modal and Targeted Imaging Improves Automated Mid-Brain Segmentation.

多模态和靶向成像改善了自动化中脑分割。

• DOI: 10.1117/12.2254428
• 发表时间: 2017
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Plassard,AndrewJ;D'Haese,PierreF;Pallavaram,Srivatsan;Newton,AllenT;Claassen,DanielO;Dawant,BenoitM;Landman,BennettA
• 通讯作者: Landman,BennettA

Evaluation of Six Registration Methods for the Human Abdomen on Clinically Acquired CT.

• DOI: 10.1109/tbme.2016.2574816
• 发表时间: 2016-08
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Xu Z;Lee CP;Heinrich MP;Modat M;Rueckert D;Ourselin S;Abramson RG;Landman BA
• 通讯作者: Landman BA