Computer-Assited Functional Neurosurgery

计算机辅助功能神经外科

• 批准号: 9149069
• 负责人: BENOIT M. DAWANT
• 金额: $ 60.93万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149069
• 关键词: Access to Information; Accounting; Adverse effects; Algorithms; Anatomy; Atlases; Behavior Disorders; Brain; Caliber; Cell Nucleus; Charge; Clinical; Cognitive; Collaborations; Complex; Computers; Data; Data Aggregation; Databases; Deep Brain Stimulation; Development; Devices; Disease; Electrodes; Emotional; Funding; Goals; Health; Image; Implant; Institution; Label; Lead; Libraries; Life; Location; Magnetic Resonance; Measures; Mood Disorders; Motor; Movement Disorders; Neurologic; Neurologist; Operative Surgical Procedures; Outcome; Patient Care; Patients; Phase; Physiological; Population; Positioning Attribute; Postoperative Period; Procedures; Process; Production; Quality of life; Research; Resources; Science; Site; Speed; Staging; Structure; System; Technology; Testing; Time; Visit; Work; catalyst; clinical research site; data exchange; data sharing; electronic data; implantation; improved; individual patient; neurosurgery; point of care; prevent; programs; public health relevance; reduce symptoms; repository; research clinical testing; response; scale up; tool; validation studies

 DESCRIPTION (provided by applicant): Deep-brain stimulation (DBS) procedures, which are increasingly used to treat a spectrum of movement, mood and behavioral disorders, are complex. Effective electrode implantation requires a painstaking procedure that begins with the challenging task of correlating anatomical target selection with physiological correction to account for patient variance and intraoperative brain shift. Following implantation, stimulation parameters that reduce symptoms while minimizing side effects need to be selected through a test-and-observe process that can be lengthy and spread over several visits. Over the last two funding periods of this project we have developed a system that provides assistance for all phases of the procedure. This system is the first one that permits the capture, storage, and spatial normalization of all data pertaining to DBS cases. This permits the creation of population-derived statistical atlases, customization of this information to individual patients, ad access to this information at the time and point of care. This system has been integrated into the clinical flow at our institution and contains data from more than 1400 subjects acquired at multiple institutions. We have shown that this system has a positive impact on the planning, placement, and programming phases of the procedure and, thanks to commercial partnerships we have established, components of our system are already available for routine clinical use. In this funding period, we will build on our previous efforts to continue the clinical evaluation of or system, expand its functionality, and deploy it at collaborating sites. Our long term goals are to develop and field (1) the first integrated DBS solution that will permit seamless exchange of information between all phases of the procedure and (2) a shared and global resource that will allow rapid dissemination of discovery and outcomes related to specific brain targets. It will thus be a catalyst that can both speed up discoveries in neurological sciences and improve clinical processes.

 描述（由申请人提供）：脑深部电刺激（DBS）程序越来越多地用于治疗一系列运动、情绪和行为障碍，这些程序非常复杂。有效的电极植入需要一个艰苦的过程，首先是将解剖目标选择与生理校正相关联的挑战性任务，以考虑患者的差异和术中脑移位。植入后，需要通过测试和观察过程来选择减少症状同时最大限度地减少副作用的刺激参数，该过程可能很长，并分散在几次访视中。在该项目的最后两个资助期内，我们开发了一个系统，为程序的所有阶段提供援助。该系统是第一个允许捕获，存储和空间标准化的所有数据有关的DBS情况。这允许创建人群衍生的统计地图集，为个体患者定制该信息，以及在护理时和护理点访问该信息。该系统已被集成到我们机构的临床流程中，包含来自多个机构的1400多名受试者的数据。我们已经证明，该系统对手术的计划，放置和编程阶段具有积极的影响，并且由于我们建立了商业合作伙伴关系，我们系统的组件已经可用于常规临床使用。在此资助期内，我们将在之前工作的基础上继续对或系统进行临床评价，扩展其功能，并将其部署在合作研究中心。我们的长期目标是开发和现场（1）第一个集成的DBS解决方案，将允许程序的所有阶段之间的无缝信息交换和（2）共享和全球资源，将允许快速传播与特定大脑目标相关的发现和结果。因此将 成为一种催化剂，既可以加速神经科学的发现，又可以改善临床过程。