Development of SFS Fractionators
SFS分馏塔的开发
基本信息
- 批准号:8712743
- 负责人:
- 金额:$ 22.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-01 至 2014-11-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBiological AssayBiological FactorsBiomassBiotechnologyCarbon DioxideCastorCollectionComplex MixturesDevelopmentDrug IndustryEmotionalEquipmentErinaceidaeEthanolExhibitsFoodFractionationGasesGenerationsGenesGingerGoalsHealthHealth BenefitHourHumanHypericum perforatumLegal patentLibrariesLicensingLiliumLiquid substanceMarinesMasksMedicineMethanolMicrobeModalityMolecularNational Center for Complementary and Alternative MedicineNatural Products ChemistryNausea and VomitingNeedlesNoiseNutraceuticalOrganic solvent productOxidoreductasePaclitaxelPathway interactionsPenetrationPersonal SatisfactionPharmaceutical PreparationsPharmacologic SubstancePhasePhase III Clinical TrialsPlantsPopulationPowder dose formProbabilityProcessPropertyProstateProtocols documentationRecoveryResearchResearch InstituteResearch MethodologyResearch PersonnelResearch Project GrantsResourcesSabal serrulataSamplingSerotoninSiteSmall Business Innovation Research GrantSoftware DesignSolidSolventsSourceStructureTaxoidsTaxusTechnologyTestingTherapeuticThermodynamicsTimeTraditional MedicineTreesUniversitiesVeratrumWorld Health Organizationbasebryostatincostcost effectivecyclopaminedesigndietary supplementsdrug discoveryhyperforinimprovedmethod developmentmicroorganismparallel processingproduct developmentprogramsprototypepublic health relevanceresearch and developmentreuptakescreeningshogaoluser-friendly
项目摘要
DESCRIPTION (provided by applicant): The screening of a complex mixture of analytes is not always successful in sensitive screens for specific activities. Often, specific activities are masked by interfering compounds or false positives are given by ubiquitous compounds that interact with all screens. This problem can be resolved by purification of the analytes. Such an approach is not only cost-prohibitive but will also result in biasing the isolation of analytes tha occur in higher concentrations. Conventional organic solvents are not always ideal for biomass extractions. These solvents can be difficult to remove from the compounds potentially exhibiting bioactivity and, thus can mask bioactivity in an assay. In order to enhance the drug and dietary supplement discovery process, we have developed and patented processes for the polarity-guided fractionation of plants and microbes (Castor et al., 1998, 2003) using supercritical fluid solvents. The overall goal of this research project is to develop a commercial, user-friendly SuperFluidsTM CXF fractionator that can be utilized by researchers at universities and pharmaceutical companies to facilitate the drug discovery and nutraceutical product development process. The primary Phase I object is to design a parallel processing CXF fractionator, and to construct and test a single unit CXF prototype that can process samples in accordance to a pre-defined sequentially increasing-polarity protocol. The unit will have the capability to rapidly produce partially purified natural product molecules from terrestrial plants and marine microorganisms, for example, 6 varying polarity fractions in about 1 hour. In Phase I, we plan to design SuperFluidsTM CXF prototypes, construct key components of the prototypes, and test these components. In Phase II, we plan to complete the hardware and software design of the SuperFluidsTM fractionation unit, assemble single and parallel processing Alpha-site units, test the units at a Beta-site, and redesign and reconstruct as necessary to eliminate bugs and increase user-friendliness. In Phase III, OEM companies will manufacture commercial units. In Phase III, we plan to sell SFS fractionation units, which will include license to utilize the SFS-CXF technologies and equipment, to researchers and product developers at universities as well as nutraceutical, food, pharmaceutical and biotechnology companies.
描述(由申请方提供):在特定活性的敏感筛选中,分析物复杂混合物的筛选并不总是成功的。通常,特异性活性被干扰化合物掩盖,或者假阳性由与所有筛选相互作用的普遍存在的化合物给出。这个问题可以通过纯化分析物来解决。这种方法不仅成本高昂,而且还将导致偏置以较高浓度出现的分析物的分离。传统的有机溶剂对于生物质提取并不总是理想的。这些溶剂可能难以从潜在表现出生物活性的化合物中除去,因此可能在测定中掩盖生物活性。为了增强药物和膳食补充剂的发现过程,我们开发了植物和微生物极性引导分级分离的工艺并获得专利(Castor等人,1998,2003)使用超临界流体溶剂。该研究项目的总体目标是开发一种商业化的、用户友好的SuperFluidsTM CXF分馏器,可供大学和制药公司的研究人员使用,以促进药物发现和营养产品开发过程。第一阶段的主要目标是设计一个并行处理CXF分馏器,并构建和测试一个单一的单元CXF原型,可以处理样品按照预定义的顺序增加极性协议。该装置将有能力从陆地植物和海洋微生物中快速生产部分纯化的天然产物分子,例如,在约1小时内生产6种不同极性的级分。在第一阶段,我们计划设计SuperFluidsTM CXF原型,构建原型的关键组件并测试这些组件。在第二阶段,我们计划完成SuperFluidsTM分馏单元的硬件和软件设计,组装单个和并行处理Alpha站点单元,在Beta站点测试单元,并根据需要进行重新设计和重建,以消除错误并提高用户友好性。在第三阶段,OEM公司将生产商业设备。在第三阶段,我们计划向大学的研究人员和产品开发人员以及营养品、食品、制药和生物技术公司出售SFS分馏装置,其中包括使用SFS-CXF技术和设备的许可证。
项目成果
期刊论文数量(0)
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