2014 Protein Transport Across Cell Membrane Gordon Research Conference and Gordon

2014年蛋白质跨细胞膜转运戈登研究会议和戈登

• 批准号: 8643955
• 负责人: Ramanujan S Hegde
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8643955
• 关键词: Achievement; Area; Biochemistry; Biogenesis; Cell Surface Receptors; Cell membrane; Cell physiology; Cells; Cellular Membrane; Cellular biology; Cryoelectron Microscopy; Crystallography; Defect; Discipline; Disease; Ensure; Environment; Explosion; Feedback; Fees; Fostering; Funding; Future; Gender; Generations; Genetic; Goals; Health; Hereditary Disease; Human; Image; Incentives; Inherited; Intracellular Membranes; Knowledge; Membrane Proteins; Mentors; Methodology; Microbe; Microscopy; Minority; Organelles; Participant; Pathway interactions; Pharmacologic Substance; Postdoctoral Fellow; Preparation; Protein translocation; Proteins; Recording of previous events; Request for Proposals; Research; Research Personnel; Resolution; Role; Schedule; Scientist; Seasons; Senior Scientist; Sorting - Cell Movement; Source; Specialist; Students; System; Texas; Therapeutic; Time; Training; Travel; United States National Institutes of Health; Virulence Factors; Woman; Work; abstracting; base; career; deep sequencing; frontier; genetic analysis; genome-wide; graduate student; human disease; male; meetings; member; next generation; peer; posters; preference; protein structure; protein transport; public health relevance; single molecule; skills; statistics; structural biology; success; symposium; trend; willingness; young woman

DESCRIPTION (provided by applicant): This proposal requests support for the 2014 Protein Transport across Cell Membranes Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) March 8-14 at the Hotel Galvez in Galveston, Texas. Elucidation of protein transport mechanisms remains a fundamental objective of modern cell biology as ~30% of all proteins are either transported across or integrated into cellular membranes. Achieving correct cellular compartmentalization by these mechanisms is essential for cell function, and different facets of protein translocation directly impact human health. Many genetic diseases result from defects in protein translocation or membrane protein insertion; infectious microbes deliver virulence factors by a variety of protein transport systems; and most current pharmaceuticals target secreted or membrane proteins. The explosion of membrane protein structures, the use of high-throughput genetic analyses, the emergence of deep sequencing, and advances in super-resolution microscopy have fueled rapid advances in the protein transport field. Thus, a dedicated protein transport conference, assembling specialists in diverse methodologies and employing various experimental systems, is essential for continued progress. This conference is the only regularly scheduled meeting in the US devoted to an in-depth coverage of this research field. The 2014 conference will open with overview presentations by prominent leaders in the field to highlight unifying concepts, major experimental systems, and emerging research areas. Each of the subsequent eight sessions, organized by research topic, will incorporate talks that employ different methodologies. This cross-disciplinary juxtaposition seeks to stimulate new research directions within each area. Research topics will include: 1) sorting and targeting of proteins to different intracellular membranes, 2) the passage of proteins through translocation channels, 3) the mechanisms of membrane protein insertion and assembly, 4) the structural biology of transport machines, 5) specialized pathogenic transport pathways, 6) biogenesis of organelles, and others. Discussion leaders and speakers for each session will include both established leaders and early career scientists. The organizers are also keenly focused on nurturing the next generation of scientists in this field. We will therefore continue the postdoc-organized GRS to sharpen the skills of postdocs and students in presentation, discussion, and interaction with senior investigators. Statistics for the last four protein transport GRCs indicate an influx of young women into this historically male-dominated field. We aim to encourage that trend with preference for selection of GRC and GRS speakers and discussion leaders. Preference for talk selection will also be given to minorities to increase diversity in this field. Funds are requested from NIH for partial support of registration and travel for GRC speakers and discussion leaders, as well as exceptional early career investigators who speak at the GRS. Achievement of our objectives will result in a highly dynamic and interactive conference that also ushers a young and diverse generation into this discipline of cell biology.

描述（由申请人提供）：本提案要求支持3月8日至14日在德克萨斯州加尔维斯顿加尔维斯酒店举行的2014年蛋白质跨细胞膜运输戈登研究会议（GRC）和戈登研究研讨会（GRS）。蛋白质转运机制的阐明仍然是现代细胞生物学的一个基本目标，因为大约30%的蛋白质要么通过细胞膜转运，要么整合到细胞膜上。通过这些机制实现正确的细胞区隔化对细胞功能至关重要，蛋白质易位的不同方面直接影响人类健康。许多遗传病是由于蛋白质易位或膜蛋白插入缺陷引起的；传染性微生物通过多种蛋白质运输系统传递毒力因子；目前大多数药物的目标是分泌蛋白或膜蛋白。膜蛋白结构的爆炸、高通量遗传分析的使用、深度测序的出现以及超分辨率显微镜的进步推动了蛋白质转运领域的快速发展。因此，召开专门的蛋白质转运会议，召集不同方法的专家并采用各种实验系统，对于持续取得进展至关重要。该会议是美国唯一定期召开的会议，致力于深入报道这一研究领域。2014年会议将以该领域杰出领导人的概述演讲开场，以突出统一概念、主要实验系统和新兴研究领域。随后的8次会议，按研究主题组织，将包括采用不同方法的会谈。这种跨学科的并置旨在激发每个领域内新的研究方向。研究主题将包括：1)蛋白质在不同细胞膜上的分选和靶向，2)蛋白质通过易位通道，3)膜蛋白插入和组装的机制，4)运输机器的结构生物学，5)专门的致病运输途径，6)细胞器的生物发生等。每次会议的讨论领导和演讲者将包括已建立的领导者和早期职业科学家。组织者也非常注重培养该领域的下一代科学家。因此，我们将继续开展博士后组织的GRS，以提高博士后和学生在演讲、讨论和与高级研究员互动方面的技能。最后四种蛋白质转运GRCs的统计数据表明