Structure Based Characterization of gp120 Non-V3 Variable Loop Epitopes

gp120 非 V3 可变环表位的基于结构的表征

• 批准号: 8733248
• 负责人: TIMOTHY J CARDOZO
• 金额: $ 62.36万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-29 至 2016-01-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8733248
• 关键词: Administrative Supplement; Antigens; Award; Budgets; Epitopes; Funding; Glycopeptides; Goals; Grant; HIV Envelope Protein gp120; Modeling; Oryctolagus cuniculus; Peptides; Progress Reports; Public Health; Research; Structure; Testing; United States National Institutes of Health; Work; abstracting; base; design; human monoclonal antibodies; immunogenicity

No abstract provided

未提供摘要

项目成果

Assessment of immunologically relevant dynamic tertiary structural features of the HIV-1 V3 loop crown R2 sequence by ab initio folding.

• DOI: 10.3791/2118
• 发表时间: 2010-09-15
• 期刊: Journal of visualized experiments : JoVE
• 作者: Almond, David;Cardozo, Timothy
• 通讯作者: Cardozo, Timothy

Comparative magnitude of cross-strain conservation of HIV variable loop neutralization epitopes.

• DOI: 10.1371/journal.pone.0015994
• 发表时间: 2010-12-29
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Swetnam J;Shmelkov E;Zolla-Pazner S;Cardozo T
• 通讯作者: Cardozo T

Sequence-conserved and antibody-accessible sites in the V1V2 domain of HIV-1 gp120 envelope protein.

HIV-1 gp120 包膜蛋白 V1V2 结构域中的序列保守且抗体可及的位点。

• DOI: 10.1089/aid.2014.0034
• 发表时间: 2014
• 期刊: AIDS research and human retroviruses
• 影响因子: 1.5
• 作者: Shmelkov,Evgeny;Grigoryan,Arsen;Krachmarov,Chavdar;Abagyan,Ruben;Cardozo,Timothy
• 通讯作者: Cardozo,Timothy

Could vaccination with AIDSVAX immunogens have resulted in antibody-dependent enhancement of HIV infection in human subjects?

接种 AIDSVAX 免疫原是否会导致人类受试者中 HIV 感染的抗体依赖性增强？

• DOI: 10.4161/21645515.2014.972148
• 发表时间: 2014
• 期刊: Human vaccines & immunotherapeutics
• 影响因子: 4.8
• 作者: Shmelkov,Evgeny;Nadas,Arthur;Cardozo,Timothy
• 通讯作者: Cardozo,Timothy