Investigating the role of Kaposi sarcoma herpesvirus Bcl-2 in tumourigenesis

研究卡波西肉瘤疱疹病毒 Bcl-2 在肿瘤发生中的作用

• 批准号: nhmrc : 1007918
• 负责人: A/Pr Marc Kvansakul
• 金额: $ 28.63万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-kaposi-2-tumourigenesis/109257
• 关键词: Investigating; role; Kaposi; sarcoma; herpesvirus

Failure to remove damaged, infected or unwanted cells via programmed cell death leads to a number of diseases, including cancers and auto-immune diseases. Viruses have the ability to subvert the host cell death machinery for their own benefit. Viral infections have been linked to a number of cancers. We aim to target the ability of viruses to subvert the process of cell death to develop new treatments against virus-linked cancers including Kaposi’s sarcoma or primary effusion lymphoma.

未能通过程序性细胞死亡去除受损、感染或不需要的细胞会导致许多疾病，包括癌症和自身免疫性疾病。病毒有能力为了自身的利益而颠覆宿主细胞的死亡机制。病毒感染与许多癌症有关。我们的目标是针对病毒颠覆细胞死亡过程的能力，开发新的治疗病毒相关癌症的方法，包括卡波西氏肉瘤或原发性渗出性淋巴瘤。