Center for Transport Oncophysics

运输肿瘤物理学中心

• 批准号: 8737802
• 负责人: MAURO FERRARI
• 金额: $ 90万
• 依托单位: METHODIST HOSPITAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8737802
• 关键词: Address; Animal Model; Architecture; Area; Biological; Biology; Cancer Burden; Carbon Nanotubes; Clinical; Colorectal Cancer; Engineering; Gold Colloid; Institution; Instruction; Investigation; Laws; Lesion; Malignant Neoplasms; Malignant neoplasm of liver; Mathematics; Metastatic Neoplasm to the Liver; Modality; Oral Administration; Physics; Pilot Projects; Principal Investigator; Research Personnel; Staging System; System; Therapeutic; Treatment Efficacy; University of Texas M D Anderson Cancer Center; cancer diagnosis; cancer therapy; human disease; imaging probe; improved; innovation; instrumentation; novel; operation; programs; tumorigenesis; vector

The proposed Center for Transport OncoPhysics (CTO) is a collaborative program among five institutions. The Principal Investigator is Dr. Mauro Ferrari (UTHSC-H) and the Senior Co-Investigator is Dr. Steven Curley (MDACC). Thus, the first overall specific aim of the proposed CTO is to construct a ¿reference system¿ for the understanding of cancer, where the multi-dimensional ¿unit vectors¿ are the differential laws of transport physics across a fundamental set of biobarriers as they present themselves and evolve in tumorigenesis (i.e., ¿transport oncophysics¿). The second overarching Specific Aim is to demonstrate the therapeutic efficacy of the novel systems and approaches developed within the CTO (multi-stage systems, nanoshuttles, carbon nanotubes, gold colloids, oral administration carriers) in the respective animal models. The proposed CTO will feature: 1. A single scientific framework (¿transport oncophysics¿ as the differential, and biological barriers as the transport nodes); 2. An integrated ¿multiple multi-scale¿ approach (our mathematics, engineered probes, and imaging instrumentation are all multiscale, and are here employed to study the multiscale architecture of the biological barriers) reflected in shared cores and all project platforms being available to serve as cores for other projects; 3. A ¿dual-intent¿ operational approach, with the engineered transport probes used for basic discovery also being employed for the demonstration of innovative therapeutic modalities addressing unsolved clinical needs in two cancer focus cluster areas; 4. An integrated choice of cancer focus and animal models. The first focus cluster is liver cancer, both primary and metastatic (Projects 1-2), the second is colorectal cancer (Projects 3), with cogent connections being the liver metastasis aspect of colorectal cancer, and the choice of unified animal models that sincerely recapitulate human diseases, under the guidance of Dr. Fidler. Further investigations that address complementary and synergistic aspects of transport onco-physics will be launched throughout the operations of the CTO by means of the Pilot Projects mechanism.

拟议的运输Oncophysics（CTO）是五个机构中的协作计划。首席研究员是Mauro Ferrari博士（UTHSC-H），高级共同研究员是Steven Curley博士（MDACC）。这是，提议的CTO的第一个总体特定目的是构建一种参考系统，以理解癌症，而多维的单位矢量是跨肿瘤造型的基本生物载体的差异化物理定律（即，在肿瘤中都进化（即，运输Oncophysics知识）。第二个总体具体目的是证明在CTO内开发的新型系统和方法的治疗效率（多阶段系统，纳米菌，碳纳米管，金核苷，口服给药载体）在各自的动物模型中。拟议的CTO将具有：1。单个科学框架（将肿瘤物理作为差异和生物屏障作为运输节点）； 2。一种集成的多尺度方法（我们的数学，工程问题和成像仪器都是多尺度的，在这里被用来研究共享核心的生物障碍的多尺度体系结构），所有项目平台都可以用作其他项目的核心； 3。一种双重操作方法，用于基本发现的工程运输项目也被用于展示创新的治疗方式，以满足两个癌症聚焦集群区域未解决的临床需求； 4。癌症焦点和动物模型的综合选择。第一个焦点簇是原发性和转移性肝癌（项目1-2），第二个是大肠癌（项目3），伴侣的联系是大肠癌的肝转移，以及在Fidler博士的指导下，对统一动物模型的选择，这些统一动物模型可真实地概括人类疾病。通过试点项目机制，将在CTO的整个运营过程中启动进一步的调查，以解决运输Onco物理学的完整和协同方面的研究。

项目成果

Vascular Inflammation: A Novel Access Route for Nanomedicine.

• DOI: 10.14797/mdcj-12-3-169
• 发表时间: 2016-11
• 期刊: Methodist DeBakey cardiovascular journal
• 作者: R. Molinaro;Christian Boada;Guillermo Medrano del Rosal;Kelly A. Hartman;C. Corbo;Elizabeth D Andrews;Naama E. Toledano-Furman;J. Cooke;E. Tasciotti

Luciferase-based protein denaturation assay for quantification of radiofrequency field-induced targeted hyperthermia: developing an intracellular thermometer.

• DOI: 10.3109/02656736.2012.666318
• 发表时间: 2012
• 期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
• 作者: Raoof M;Zhu C;Kaluarachchi WD;Curley SA
• 通讯作者: Curley SA

Optical fine-needle imaging biopsy of the brain.

脑部光学细针成像活检。

• DOI: 10.1364/boe.4.002846
• 发表时间: 2013
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Kim,JunKi;Choi,JinWoo;Yun,SeokH
• 通讯作者: Yun,SeokH

Chlorin e6 Functionalized Theranostic Multistage Nanovectors Transported by Stem Cells for Effective Photodynamic Therapy.

• DOI: 10.1021/acsami.7b05766
• 发表时间: 2017-07-19
• 期刊: ACS applied materials & interfaces
• 影响因子: 9.5
• 作者: Näkki S;Martinez JO;Evangelopoulos M;Xu W;Lehto VP;Tasciotti E
• 通讯作者: Tasciotti E

Sustained zero-order release of intact ultra-stable drug-loaded liposomes from an implantable nanochannel delivery system.

• DOI: 10.1002/adhm.201300188
• 发表时间: 2014-02
• 期刊: ADVANCED HEALTHCARE MATERIALS
• 影响因子: 10
• 作者: Celia, Christian;Ferrati, Silvia;Bansal, Shyam;van de Ven, Anne L.;Ruozi, Barbara;Zabre, Erika;Hosali, Sharath;Paolino, Donatella;Sarpietro, Maria Grazia;Fine, Daniel;Fresta, Massimo;Ferrari, Mauro;Grattoni, Alessandro
• 通讯作者: Grattoni, Alessandro