Center for Transport Oncophysics

拟议的运输肿瘤物理中心(CTO)是五个机构之间的合作计划。首席调查员是毛罗·费拉里博士(UTHSC-H)，高级联合调查员是Steven Curley博士(MDACC)。因此，拟议的CTO的第一个总体具体目标是为理解癌症构建一个参考系统，其中多维单位向量是一组基本生物屏障在其自身存在和在肿瘤发生中演变时的传输物理的微分定律(即，传输物理)。第二个主要的具体目标是展示在CTO(多阶段系统、纳米航天飞机、碳纳米管、金胶体、口服给药载体)内开发的新系统和方法在各自的动物模型中的治疗效果。拟议的CTO将具有以下特点：1.单一的科学框架(以传输物理为差异，以生物屏障为传输节点)；2.综合的多多尺度方法(我们的数学、工程探测器和成像仪器都是多尺度的，在这里用于研究生物屏障的多尺度结构)，反映在共享的核心和所有可用作其他项目的核心的项目平台中；3.双重意图的操作方法，用于基本发现的工程运输探针也被用于展示解决两个癌症焦点聚集区未解决的临床需求的创新治疗模式；4.癌灶和动物模型的综合选择。第一个焦点组是肝癌，包括原发和转移(项目1-2)，第二个是结直肠癌(项目3)，有说服力的连接是结直肠癌的肝转移方面，在Fidler博士的指导下，选择了真诚概括人类疾病的统一动物模型。将通过试点项目机制，在CTO的整个业务过程中开展进一步的调查，以解决运输相关物理的互补和协同方面问题。

The proposed Center for Transport OncoPhysics (CTO) is a collaborative program among five institutions. The Principal Investigator is Dr. Mauro Ferrari (UTHSC-H) and the Senior Co-Investigator is Dr. Steven Curley (MDACC). Thus, the first overall specific aim of the proposed CTO is to construct a ¿reference system¿ for the understanding of cancer, where the multi-dimensional ¿unit vectors¿ are the differential laws of transport physics across a fundamental set of biobarriers as they present themselves and evolve in tumorigenesis (i.e., ¿transport oncophysics¿). The second overarching Specific Aim is to demonstrate the therapeutic efficacy of the novel systems and approaches developed within the CTO (multi-stage systems, nanoshuttles, carbon nanotubes, gold colloids, oral administration carriers) in the respective animal models. The proposed CTO will feature: 1. A single scientific framework (¿transport oncophysics¿ as the differential, and biological barriers as the transport nodes); 2. An integrated ¿multiple multi-scale¿ approach (our mathematics, engineered probes, and imaging instrumentation are all multiscale, and are here employed to study the multiscale architecture of the biological barriers) reflected in shared cores and all project platforms being available to serve as cores for other projects; 3. A ¿dual-intent¿ operational approach, with the engineered transport probes used for basic discovery also being employed for the demonstration of innovative therapeutic modalities addressing unsolved clinical needs in two cancer focus cluster areas; 4. An integrated choice of cancer focus and animal models. The first focus cluster is liver cancer, both primary and metastatic (Projects 1-2), the second is colorectal cancer (Projects 3), with cogent connections being the liver metastasis aspect of colorectal cancer, and the choice of unified animal models that sincerely recapitulate human diseases, under the guidance of Dr. Fidler. Further investigations that address complementary and synergistic aspects of transport onco-physics will be launched throughout the operations of the CTO by means of the Pilot Projects mechanism.