Genetic Analysis Of Non-alzheimer Dementias

我们使用基于密集SNP的连锁图谱来识别与家族性额颞叶痴呆相关的新的基因座。这项工作表明，9号染色体上现有的一个基因座重叠，我们现在知道这也是肌萎缩侧索硬化症的一个危险基因。这个定位克隆的努力是由Traynor博士的团队领导的(另一份报告)，这个基因座是我们实验室去年发现的。我们正在进行的路易体痴呆症和帕金森氏病痴呆症的工作主要集中在分析我们的阿尔茨海默病和帕金森氏病全基因组关联研究中确定的基因座，看看我们是否可以梳理出这些疾病中痴呆症的遗传基础，从神经病理学上讲，这些疾病位于阿尔茨海默病和帕金森氏病之间。我们正在FTD上发表我们的GWAS结果，其中显示了这种疾病的两个重复的风险基因。

We have used dense SNP based linkage mapping to identify novel loci associated with familial frontotemporal dementia. This work shows linkage overlapping an extant locus on chromosome 9 which we now is understand is also a risk locus for amyotrophic lateral sclerosis. This positional cloning effort is being lead by Dr. Traynor's group (separate report) and this locus has int he last year been discovered by our laboratory. Our ongoing work on dementia with Lewy bodies and Parkinson's disease with dementia primarily focuses on analysis of loci identified in our genome wide association studies in Alzheimer's disease and Parkinson's disease to see if we can tease out the genetic basis of dementia in these disorders which neuropathologically sit between Alzheimer's and Parkinson's disease. We are in the process of publishing the results of our GWAS in FTD which shows two replicated risk loci for this disorder.