Genetic Analysis of Dementia Disorders Neuropathologically Between Alzheimer's and Parkinson's Disease

我们正在进行的路易体痴呆症、额颞叶痴呆症和帕金森氏病痴呆症的工作主要集中在分析我们在阿尔茨海默病和帕金森病的全基因组关联研究中确定的基因座，看看我们是否可以梳理出这些疾病的痴呆症的遗传基础，从神经病理学上讲，这些疾病位于阿尔茨海默病和帕金森病之间。 我们继续致力于痴呆症与路易小体和额颞部痴呆的全基因组关联研究，并扩大了我们在这一领域的工作，包括3000个DLB，3000个FTD病例的全基因组测序。该项目第一阶段的数据生成现已完成，并进行了质量控制。这些数据将首先通过AMP-PD门户网站在线发布。

Our ongoing work on dementia with Lewy bodies, frontotemporal dementia, and Parkinson's disease with dementia primarily focuses on analysis of loci identified in our genome wide association studies in Alzheimer's disease and Parkinson's disease to see if we can tease out the genetic basis of dementia in these disorders which neuropathologically sit between Alzheimer's and Parkinson's disease. We continue to work on genome wide association studies in dementia with Lewy bodies and frontotemporal dementia, and we have expanded our work in this area to include whole genome sequencing in 3000 DLB, 3000 FTD cases. Data generation for the first phase of this project is now complete, and quality control has been performed. The data will be released online through the AMP-PD portal in the first instance.