Genetically Informed Study of Marital Functioning and Depression at Midlife

婚姻功能和中年抑郁症的遗传学研究

• 批准号: 8588218
• 负责人: Christopher Ryan Beam
• 金额: $ 2.04万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-23 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8588218
• 关键词: Address; Adult; Affect; Age; Aging; Behavior; Climacteric; Clinical; Communication; Data; Data Set; Development; Divorce; Elderly; Equation; Event; Factor Analysis; Functional disorder; Funding; Genetic; Genetic Predisposition to Disease; Genetic Risk; Grant; Intervention; Knowledge; Life; Link; Longevity; Maps; Marital Relationships; Marriage; Measurement; Measures; Mediating; Mental Depression; Mentors; Methodology; Methods; National Research Service Awards; Outcome; Parenting behavior; Parents; Pathway interactions; Process; Property; Psyche structure; Research; Research Personnel; Research Support; Research Training; Risk; Sampling; Spouses; Staging; Structure; Testing; Time; Training; Training Programs; Twin Multiple Birth; United States; Work; cohort; depressive symptoms; design; gene environment interaction; genetic association; geriatric depression; indexing; intimate behavior; middle age; mortality; prevent; programs; psychologic; public health relevance; satisfaction; skills; social; trend

DESCRIPTION (provided by applicant): Hundreds of studies link poor marital functioning to depression. Few recent studies have investigated their association among adults in the second half of the lifespan. There is a need to understand how key marital variables affect wellbeing during midlife and beyond given the recent rise in divorce among the baby boomers. However, the causal, as opposed to merely correlational, pathway between marital functioning and depression is difficult to establish decisively. Twin methodology offers one way to control for nonrandom genetic and environmental selection confounds that often obscure causal findings in nonexperimental data. The proposed research will examine: whether changes in marital behaviors cause changes in depression over time in midlife (Specific Aim 1); whether midlife parenting transitions moderate the genetic risk for depressive symptoms associated with changes in marital dysfunction (Specific Aim 2); and whether the structure of facets of married life changes over different stages of midlife development (Specific Aim 3). The proposed research will use a genetically informed subsample of middle-aged married parents (N = 2,402) from the Midlife Development in the United States (MIDUS) study, a two-wave data set that includes multiple scales of marital functioning and clinical and nonclinical depressive symptom measures. The research training program is designed to develop the applicants methodological, quantitative, and theoretical skills to launch his program of research on depression and intimate relationships over the lifespan. The applicant will receive mentoring from theoretical and quantitative experts in his field to use latent stable and change score structural equation methods, gene- environment interaction methods, and other factor analytic methods (idiographic filtering) to study the etiological pathways underlying marital quality and depression during midlife, to operationalize and test stressful midlife moderators that may "turn on" the genetic ris factors mediating the association between depression and marital dysfunction, and to explore how some marital behaviors matter more during one stage of midlife than at others. While funded by Institutional NRSA Quantitative Training Grant (T32AG020500, PI Nesselroade), preliminary factor analyses with the MIDUS data reveal a genetic etiology for latent marital quality and depression, significant negative correlations between marital quality and depression within and over time, and sufficient power to detect small-to-moderate sized genetic and environmental main effects of marital quality on depression. The proposed research supports the NIA¿s Strategic Direction A-1 by helping map the social and genetic pathways between dysfunctional marriages and wellbeing. The findings will inform interventions for healthy physical and mental wellbeing in the second half of the lifespan.

描述（由申请人提供）：数百项研究将婚姻功能不佳与抑郁症联系起来。最近很少有研究调查它们在成年人后半生之间的关系。鉴于最近婴儿潮一代离婚率的上升，有必要了解关键的婚姻变量是如何影响中年及以后的幸福感的。然而，婚姻功能和抑郁之间的因果关系，而不仅仅是相关关系，是很难确定的。双生子方法提供了一种控制非随机遗传和环境选择混淆的方法，这些混淆常常使非实验数据中的因果结果模糊不清。拟议的研究将检验：随着时间的推移，婚姻行为的改变是否会导致中年抑郁症的变化（具体目标1）；中年养育方式的转变是否会缓和与婚姻功能障碍变化相关的抑郁症状的遗传风险（特定目标2）；以及婚姻生活各方面的结构是否在中年发展的不同阶段发生变化（具体目标3）。拟议的研究将使用来自美国中年发展（MIDUS）研究的中年已婚父母的遗传信息亚样本（N = 2,402），这是一个两波数据集，包括婚姻功能和临床和非临床抑郁症状测量的多个尺度。该研究培训计划旨在培养申请人的方法、定量和理论技能，以开展其关于抑郁症和亲密关系的研究项目。申请人将在本领域理论与定量专家的指导下，运用潜稳变分结构方程法、基因-环境相互作用法等因素分析方法（具体筛选法），研究婚姻质量与中年抑郁的病因通路；实施和测试中年压力调节因子，这些调节因子可能“开启”介导抑郁和婚姻功能障碍之间关联的遗传风险因素，并探讨某些婚姻行为在中年某一阶段比在其他阶段更重要的原因。在机构NRSA定量培训基金（T32AG020500, PI Nesselroade）的资助下，使用MIDUS数据进行的初步因素分析揭示了潜在婚姻质量和抑郁症的遗传病因学，婚姻质量和抑郁症在一段时间内和一段时间内呈显著负相关，并且有足够的能力检测出婚姻质量对抑郁症的小到中等程度的遗传和环境主要影响。这项拟议的研究支持了NIA的战略方向A-1，帮助绘制出不正常婚姻和幸福之间的社会和遗传途径。这些发现将为生命后半段的健康身心健康提供干预措施。