Midcareer Investigator Award in Patient-Oriented Research

描述（由申请人提供）：这是一个K24指导奖在病人为导向的研究在老龄化从马克Lachs医学博士硕士威尔康奈尔医学院的更新申请。该方案的直接目标是：（1）与琳达·弗里德博士合作，将第一个周期创建的候选人成功的导师方案推广到哥伦比亚大学的学员，推广到任何由导师指导的老龄化研究领域（地方方案）;（2）为虐待老年人领域的初级调查人员创建一个全国导师方案（国家方案）。这两项举措都源于第一个周期中发现的阻碍两个特定学员群体职业发展的障碍。在拟议的地方计划的情况下，哥伦比亚大学的世界著名的老龄化研究活动尚未高度影响其老年医学部。在拟议的国家计划的情况下，缺乏训练有素的调查人员在虐待老年人领域谁可以指导下一代的研究人员是一个可怕的问题;拉克斯博士是美国国立卫生研究院的历史上唯一的医生科学家持有RO 1在该领域，K24机制的要求。在第一个K24周期的过程中，候选人定期与渴望导师的两种类型的学员联系;这种更新正式化了这一过程，同时继续为原始计划创建的稳定的潜在学员群体提供服务。在第一个周期取得的显著成就包括：24名各级学员的指导，他们与PI共同撰写了多份出版物，并获得了许多联邦和基金会的赠款，更新了父母RO 1-NIA历史上最大的虐待老人赠款，以研究养老院中的居民对居民的虐待（RREM），获得另外三项主要赠款给PI，作为学员的资源，以及康奈尔大学几个主要中心赠款的获得或更新（PI协助），有试点计划和其他资源，可以帮助国家和地方的学员。其中包括NIA资助的Roybal中心（由前学员卡里里德博士领导），NIMH老年抑郁症中心的更新（由长期合作者乔治亚历克西斯博士领导），以及CTSC（由部门负责人Julianne Imperato McGinley博士领导）。在第一年，提出了三个试点项目，涉及方案两个部门不同级别的学员：（1）哥伦比亚老年病学家田丹博士对轮上餐接受者补充维生素D的研究（当地项目），（2）罗切斯特大学老年精神病学家EJ桑托斯对RREM中精神病共病的研究（3）康奈尔大学艾德住院医师安东尼罗森对辅助生活设施中RREM的研究（当地项目）。PI为每个项目提供了数据集和/或研究资源，象征着后续指导的结构。该申请的另一个优势是Lachs博士的同事Jeanne Teresi博士和她在希伯来老人之家的研究小组的共同指导。作为一名心理测量学家和统计学家，Teresi博士是他目前所有项目的合作研究者，并指导了200多名老龄化研究人员。K24计划的长期目标是：（1）更充分地整合康奈尔大学和哥伦比亚大学以患者为导向的老龄化研究，从而激励更多的学员选择老龄化研究的职业，以及（2）创建一个自我维持的研究人员队伍，他们在虐待老年人方面进行以患者为导向的研究。国家和地方方案的首要和最长期目标是，随着学员承担导师角色，它们最终能够自我维持并独立于候选人。

DESCRIPTION (provided by applicant): This is an application for renewal of a K24 mentoring award in patient oriented research in aging from Mark Lachs MD MPH of the Weill Cornell Medical College. The immediate objectives of the program are (1) to extend the candidate's successful program of mentorship created in the first cycle to trainees at Columbia University in collaboration with Dr. Linda Fried in any mentee-directed area of aging research (the local program), and (2) to create a national mentorship program for junior investigators in the field of elder abuse (the national program). Both initiatives derive from barriers identified in the first cycle which hamper career development of two specific mentee constituencies. In the case of the proposed local program, the world renowned aging research activities of Columbia University have not yet highly impacted its Division of Geriatric Medicine. In the case of the proposed national program, dearth of highly trained investigators in the field of elder abuse who can mentor the next generation of researchers is a dire concern; Dr. Lachs is the only physician-scientist in the history of NIH to hold an RO1 in the field, a requirement of the K24 mechanism. Over the course of the first K24 cycle, the candidate was contacted regularly by trainees of both types desirous of mentorship; this renewal formalizes that process while continuing to serve the steady pool of potential mentees created by the original program. Notable achievements in the first cycle include: the mentorship of 24 trainees at all levels who coauthored multiple publications with the PI and received many federal and foundation grants, renewal of the parent RO1 - the largest elder abuse grant in the history of NIA to study resident to resident elder mistreatment (RREM) in nursing homes, the acquisition of three other major grants to the PI which will serve as a resource for mentees, and the acquisition or renewal of several major center grants at Cornell (with which the PI assisted) that have pilot programs and other resources than can assist mentees nationally and locally. These include an NIA funded Roybal Center (led by former mentee Dr. Cary Reid), renewal of an NIMH Geriatric Depression Center (led by longstanding collaborator Dr. George Alexopolous), and a CTSC (led by fellow Division Chief Dr. Julianne Imperato-McGinley). Three pilot projects involving mentees at different levels in both arms of the program are proposed for the initial year: (1) A study of Vitamin D supplementation in meals on wheels recipients by Columbia geriatrician Dr. Tien Dam (local program), (2) A study of psychiatric co-morbidity in RREM by University of Rochester Geriatric Psychiatrist EJ Santos (national program), and (3) a study of RREM in assisted living facilities by Cornell ED Resident Anthony Rosen (local program). The PI has made data sets and/or research resources available for each project, emblematic how subsequent mentoring will be structured. An additional strength of the application is co-mentorship from Dr. Lachs' colleague Dr. Jeanne Teresi and her research group at the Hebrew Home for the Aged. A psychometrician and statistician, Dr. Teresi is a collaborating investigator all his current projects, and has mentored over 200 individuals in aging research. The Long Term Objectives of the K24 program are (1) to more fully integrate patient oriented research in aging at Cornell and Columbia, thereby inciting more trainees to select careers in aging research, and (2) to create a self-sustaining cadre of researchers who conduct patient oriented research in elder abuse. The overarching and longest term objective for both the national and local programs is that they ultimately be self-sustaining and independent of the candidate, as mentees take on mentor roles.