Terry Beirn CPCRA Clinical Trials Unit

Terry Beirn CPRA 临床试验单位

• 批准号: 8609786
• 负责人: Fred M Gordin
• 金额: $ 325万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609786
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Affect; African American; Behavioral; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collaborations; Commit; Communities; Comorbidity; Data; Development; Diagnosis; District of Columbia; Enrollment; Ensure; Epidemic; Fostering; Funding; Goals; Grant; HIV; HIV Infections; Health; Hepatitis; Hospitals; Individual; Infection; Infectious hepatitides; Institution; Latino; Leadership; Medical; Medical center; Medicine; Mentors; Minority Groups; Names; Participant; Patient Care; Patients; Persons; Population Heterogeneity; Prevalence; Prevention; Prevention Research; Prevention strategy; Principal Investigator; Prophylactic treatment; Protocols documentation; Public Health; Publications; Randomized Clinical Trials; Regimen; Research; Research Personnel; Risk; Scientist; Site; Structure; Subgroup; Target Populations; Therapeutic; Training; Translations; Tuberculosis; Universities; Veterans; Viral hepatitis; Virginia; Virus; Washington; Woman; Work; career development; clinical research site; clinically relevant; demographics; design; expectation; experience; high risk; improved; member; next generation; novel therapeutic intervention; prevent; racial and ethnic; transmission process; tuberculosis treatment; working group

DESCRIPTION (provided by applicant): The Terry Beirn CPCRA Clinical Trials Unit is composed of investigators and research staff at 7 Clinical Research Sites with over 20 years of experience in HIV, hepatitis, tuberculosis and prevention research and patient care and with an established record of effective and efficient collaboration over the past 6 years. The CPCRA CTU aims to conduct clinically relevant research in the prevention and treatment of HIV, hepatitis, and tuberculosis; to enroll a demographically, geographically, and socio-economically diverse population of individuals into clinical trials; and to carry out this research agenda in clse collaboration with community members who are themselves affected by HIV, hepatitis, or tuberculosis. The Terry Beirn CPCRA CTU will make significant contributions to the ACTG and HPTN leadership groups, both in enrollment and in scientific expertise. Through the ACTG, the CPCRA CTU will contribute to multiple, randomized clinical trials in strategies to cure and/or achieve functional cure of HIV, studies to improve the diagnosis and treatment of tuberculosis, strategies to cure infectious hepatitis, and strategies to improve the treatment of, or prevent, non-infectious co-morbidities and evaluate novel therapeutic interventions targeting HIV infection. Through the HPTN, the CPCRA CTU will evaluate and optimize integrated strategies to prevent HIV infection, and evaluate and optimize the most promising pre-exposure prophylaxis (PrEP) regimens. Targeted populations include those who are H1V+ as well as those who are HIV- and at-risk for seroconversion, especially high-risk subgroups. The Administrative Office of the CPCRA CTU located at the Veterans Affairs Medical Center in Washington, DC, is an off-campus affiliate of the applicant organization, the George Washington University. The CTU Principal Investigator and Administrative Office staff provide oversight, coordination, training, technical assistance and regulatory support for 7 Clinical Research Sites, 6 affiliated with the ACTG (Denver Public Health, Henry Ford Hospital, Houston AIDS Research Team, Virginia Commonwealth University, Wayne State University) and 1 with HPTN (George Washington University).

描述（由申请人提供）：Terry beben CPCRA临床试验单元由7个临床研究站点的研究人员和研究人员组成，他们在艾滋病，肝炎，结核病和预防研究和患者护理方面拥有超过20年的经验，并在过去6年中建立了有效和高效的合作记录。CPCRA CTU的目标是在艾滋病、肝炎和结核病的预防和治疗方面进行临床相关研究；将人口统计学、地理上和社会经济上不同的人群纳入临床试验；并与本身受艾滋病毒、肝炎或结核病影响的社区成员密切合作开展这一研究议程。Terry beben CPCRA CTU将在招生和科学专业知识方面为ACTG和HPTN领导小组做出重大贡献。通过ACTG， CPCRA CTU将为艾滋病治愈和/或实现功能性治愈的多个随机临床试验做出贡献，研究改善结核病的诊断和治疗，治疗传染性肝炎的策略，改善治疗或预防非传染性合并症的策略，并评估针对艾滋病毒感染的新治疗干预措施。通过HPTN， CPCRA CTU将评估和优化预防艾滋病毒感染的综合策略，并评估和优化最有前途的暴露前预防（PrEP）方案。目标人群包括H1V+人群以及HIV感染者和有血清转化风险的人群，特别是高危亚群。CPCRA CTU的行政办公室位于华盛顿特区的退伍军人事务医疗中心，是申请组织乔治华盛顿大学的校外附属机构。CTU首席研究员和行政办公室工作人员为7个临床研究地点提供监督、协调、培训、技术援助和监管支持，其中6个隶属于ACTG（丹佛公共卫生、亨利福特医院、休斯顿艾滋病研究小组、弗吉尼亚联邦大学、韦恩州立大学），1个隶属于HPTN（乔治华盛顿大学）。