Terry Beirn CPCRA Clinical Trials Unit

Terry Beirn CPRA 临床试验单位

• 批准号: 8974803
• 负责人: Fred M Gordin
• 金额: $ 505.55万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8974803
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Affect; African American; Behavioral; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collaborations; Communities; Comorbidity; Data; Development; Diagnosis; District of Columbia; Enrollment; Ensure; Epidemic; Fostering; Funding; Goals; Grant; HIV; HIV Infections; Health; Hepatitis; Hospitals; Individual; Infection; Infectious hepatitides; Institution; Latino; Leadership; Medical; Medical center; Medicine; Mentors; Minority Groups; Names; Participant; Patient Care; Patients; Persons; Population Heterogeneity; Prevalence; Prevention; Prevention Research; Prevention strategy; Principal Investigator; Prophylactic treatment; Protocols documentation; Public Health; Publications; Randomized Clinical Trials; Regimen; Research; Research Personnel; Risk; Scientist; Site; Structure; Subgroup; Target Populations; Therapeutic; Training; Translations; Tuberculosis; Universities; Veterans; Viral hepatitis; Virginia; Washington; Woman; Work; career development; clinical research site; clinically relevant; demographics; design; ethnic diversity; ethnic minority population; expectation; experience; high risk; improved; member; next generation; novel therapeutic intervention; prevent; racial diversity; racial minority; seroconversion; socioeconomics; tuberculosis treatment; viral transmission; working group

DESCRIPTION (provided by applicant): The Terry Beirn CPCRA Clinical Trials Unit is composed of investigators and research staff at 7 Clinical Research Sites with over 20 years of experience in HIV, hepatitis, tuberculosis and prevention research and patient care and with an established record of effective and efficient collaboration over the past 6 years. The CPCRA CTU aims to conduct clinically relevant research in the prevention and treatment of HIV, hepatitis, and tuberculosis; to enroll a demographically, geographically, and socio-economically diverse population of individuals into clinical trials; and to carry out this research agenda in clse collaboration with community members who are themselves affected by HIV, hepatitis, or tuberculosis. The Terry Beirn CPCRA CTU will make significant contributions to the ACTG and HPTN leadership groups, both in enrollment and in scientific expertise. Through the ACTG, the CPCRA CTU will contribute to multiple, randomized clinical trials in strategies to cure and/or achieve functional cure of HIV, studies to improve the diagnosis and treatment of tuberculosis, strategies to cure infectious hepatitis, and strategies to improve the treatment of, or prevent, non-infectious co-morbidities and evaluate novel therapeutic interventions targeting HIV infection. Through the HPTN, the CPCRA CTU will evaluate and optimize integrated strategies to prevent HIV infection, and evaluate and optimize the most promising pre-exposure prophylaxis (PrEP) regimens. Targeted populations include those who are H1V+ as well as those who are HIV- and at-risk for seroconversion, especially high-risk subgroups. The Administrative Office of the CPCRA CTU located at the Veterans Affairs Medical Center in Washington, DC, is an off-campus affiliate of the applicant organization, the George Washington University. The CTU Principal Investigator and Administrative Office staff provide oversight, coordination, training, technical assistance and regulatory support for 7 Clinical Research Sites, 6 affiliated with the ACTG (Denver Public Health, Henry Ford Hospital, Houston AIDS Research Team, Virginia Commonwealth University, Wayne State University) and 1 with HPTN (George Washington University). RELEVANCE: Ongoing research on prevention and treatment of HIV, tuberculosis and hepatitis is imperative given the continued prevalence of these global infections. Investigators affiliated with the Terry Beirn CPCRA CTU and its 7 Clinical Research Sites are experienced, competent, and committed to make significant contributions to reduce the burden of these infections on people's lives.

描述（由申请人提供）：Terry Beirn CPCRA临床试验部门由7个临床研究中心的研究人员和研究人员组成，他们在HIV、肝炎、结核病和预防研究以及患者护理方面拥有20多年的经验，并在过去6年中建立了有效和高效的合作记录。CPCRA CTU旨在开展预防和治疗艾滋病毒，肝炎和结核病的临床相关研究;招募人口统计学，地理和社会经济多样化的人群参加临床试验;并与自己受艾滋病毒，肝炎或结核病影响的社区成员密切合作开展这项研究议程。Terry Beirn CPCRA CTU将为ACTG和HPTN领导小组做出重大贡献，无论是在招生还是在科学专业知识方面。通过ACTG，CPCRA CTU将为多项随机临床试验做出贡献，包括治愈和/或实现HIV功能性治愈的策略，改善结核病诊断和治疗的研究，治愈传染性肝炎的策略，以及改善治疗或预防非感染性共病的策略，并评估针对HIV感染的新型治疗干预措施。通过HPTN，CPCRA CTU将评估和优化预防艾滋病毒感染的综合战略，并评估和优化最有前途的暴露前预防（PrEP）方案。目标人群包括H1 V阳性人群以及艾滋病毒阳性和有血清转换风险的人群，特别是高风险亚群。CPCRA CTU的行政办公室位于华盛顿的退伍军人事务医疗中心，是申请组织乔治华盛顿大学的校外附属机构。CTU主要研究者和行政办公室工作人员为7家临床研究中心提供监督、协调、培训、技术援助和监管支持，其中6家附属于ACTG（丹佛公共卫生、亨利福特医院、休斯顿艾滋病研究团队、弗吉尼亚联邦大学、韦恩州立大学），1家附属于HPTN（乔治华盛顿大学）。 相关性：鉴于艾滋病毒、结核病和肝炎在全球持续流行，必须继续研究这些疾病的预防和治疗。隶属于Terry Beirn CPCRA CTU及其7个临床研究中心的研究人员经验丰富，有能力，并致力于为减轻这些感染对人们生活的负担做出重大贡献。