CPCRA Clinical Trials Unit

CPCRA 临床试验单位（临床研究社区计划）的目标 艾滋病）是：在预防和治疗艾滋病毒及其相关疾病方面进行临床相关研究 并发症；参与临床试验的人口、地理和社会经济多样化的人 感染艾滋病毒或有感染风险的人群；并在 与本身感染艾滋病毒或受艾滋病毒影响的社区成员密切合作。 CPRA CTU 将为 INSIGHT 和 HIV 预防试验 (HPTN) 做出重大贡献 网络，无论是在招生方面还是在科学专业知识方面。通过 INSIGHT，CPRA CTU 将做出贡献 进行多项随机临床试验，以帮助确定最佳的临床治疗方案 谁是艾滋病毒携带者。这些试验包括对以下人群的研究： 具有高度抗逆转录病毒 (ARV) 经验并且 无法实现和维持病毒学抑制的人；未感染抗逆转录病毒药物，患有晚期艾滋病毒疾病 因机会性感染而就诊；同时感染艾滋病毒和肝炎病毒；或在 心血管疾病的中度至高度风险。 CPRA CTU 将通过 HPTN 为试验做出贡献 通过行为和生物学结果检查行为和治疗干预措施，寻求 减少艾滋病毒传播和艾滋病毒传播风险行为。目标人群包括那些 HIV 感染者，以及 HIV 感染者和有血清转化风险的人群，例如注射吸毒者和可卡因使用者 以及其他因性接触而面临血清转化风险的人。 CPRA 临床试验部门执行办公室，位于退伍军人事务医疗中心 位于华盛顿特区，是申请机构乔治华盛顿大学的校外附属机构。 首席研究员和执行办公室工作人员提供监督、中央协调、培训和 为其 137 个临床研究中心提供教育、技术援助和监管支持，由 地区分为美国、巴西、加拿大、秘鲁和南非的 23 个站点协调中心。这些 各站点接受护理的患者群体累计超过 152,000 名，人口结构多样 艾滋病毒/艾滋病。

The objectives of the CPCRA Clinical Trials Unit (Community Programs for Clinical Research on AIDS) are: to conduct clinically relevant research in the prevention and treatment of HIV disease and its complications; to involve in clinical trials a demographically, geographically, and socio-economically diverse population of individuals infected with HIV or at risk of infection; and to carry out this research agenda in close collaboration with community members who are themselves infected with or affected by HIV. The CPCRA CTU will make significant contributions to the INSIGHT and HIV Prevention Trials (HPTN) networks, both in enrollment and in scientific expertise. Through INSIGHT, the CPCRA CTU will contribute to multiple, randomized clinical trials in order to help determine the optimal clinical management for persons who are HIV+. These trials include studies of those who are: highly-antiretroviral (ARV) experienced and for whom virologic suppression cannot be achieved and maintained; ARV-nai've, with advanced HIV disease and presenting for care with an opportunistic infection; co-infected with HIV and hepatitis virus; or at moderate-to-high risk of cardiovascular disease. Through the HPTN, the CPCRA CTU will contribute to trials examining both behavioral and therapeutic interventions with behavioral and biologic outcomes, seeking to reduce HIV transmission and HIV transmission-risk behavior. Targeted populations include those who are HIV+, as well as those who are HIV- and at-risk for seroconversion, such as injecting-drug and cocaine users and others at risk for seroconversion through sexual contact. The Executive Office of the CPCRA Clinical Trials Unit, located at the Veterans Affairs Medical Center in Washington DC, is an off-campus affiliate of the applicant institution, The George Washington University. The Principal Investigator and Executive Office staff provide oversight, central coordination, training and education, technical assistance, and regulatory support for its 137 clinical research sites, organized by region into 23 Site Coordinating Centers in the United States, Brazil, Canada, Peru, and South Africa. These sites have in care a cumulative, demographically diverse patient base of over 152,000 persons with HIV/AIDS.