CPCRA Clinical Trials Unit

CPCRA临床试验单位(社区临床研究方案)的目标 艾滋病)是：在预防和治疗艾滋病毒疾病方面进行临床相关研究 并发症；参与临床试验，涉及人口统计、地理和社会经济上的多样性 感染艾滋病毒或有感染风险的个人的人口；并在#年开展这项研究议程 与本身感染艾滋病毒或受艾滋病毒影响的社区成员密切合作。 CPCRA CTU将为Insight和HIV预防试验(HPTN)做出重大贡献 在招生和科学专门知识方面都建立了网络。通过洞察，CPCRA CTU将做出贡献 到多个随机临床试验，以帮助确定对患者的最佳临床管理 谁是艾滋病病毒感染者。这些试验包括对以下人群的研究：高度抗逆转录病毒(ARV)经验和 他们的病毒学抑制无法实现和维持；患有晚期艾滋病毒的ARV-nai 机会性感染；同时感染艾滋病毒和肝炎病毒；或 患心血管疾病的风险从中到高。通过HPTN，CPCRA CTU将为试验做出贡献 检查行为和治疗干预与行为和生物学结果，寻求 减少艾滋病毒传播和艾滋病毒传播危险行为。目标人群包括那些 艾滋病毒，以及艾滋病毒携带者和血清转换高危人群，如注射毒品和可卡因使用者 以及其他通过性接触而有血清转换风险的人。 位于退伍军人事务医疗中心的CPCRA临床试验股执行办公室 在华盛顿特区，是申请机构乔治华盛顿大学的校外分支机构。 首席调查员和执行办公室工作人员提供监督、中央协调、培训和 为其137个临床研究站点提供教育、技术援助和监管支持，由 该区域在美国、巴西、加拿大、秘鲁和南非设立了23个现场协调中心。这些 这些地点有累积的、人口结构多样化的患者基础，超过152,000人， 艾滋病毒/艾滋病。

The objectives of the CPCRA Clinical Trials Unit (Community Programs for Clinical Research on AIDS) are: to conduct clinically relevant research in the prevention and treatment of HIV disease and its complications; to involve in clinical trials a demographically, geographically, and socio-economically diverse population of individuals infected with HIV or at risk of infection; and to carry out this research agenda in close collaboration with community members who are themselves infected with or affected by HIV. The CPCRA CTU will make significant contributions to the INSIGHT and HIV Prevention Trials (HPTN) networks, both in enrollment and in scientific expertise. Through INSIGHT, the CPCRA CTU will contribute to multiple, randomized clinical trials in order to help determine the optimal clinical management for persons who are HIV+. These trials include studies of those who are: highly-antiretroviral (ARV) experienced and for whom virologic suppression cannot be achieved and maintained; ARV-nai've, with advanced HIV disease and presenting for care with an opportunistic infection; co-infected with HIV and hepatitis virus; or at moderate-to-high risk of cardiovascular disease. Through the HPTN, the CPCRA CTU will contribute to trials examining both behavioral and therapeutic interventions with behavioral and biologic outcomes, seeking to reduce HIV transmission and HIV transmission-risk behavior. Targeted populations include those who are HIV+, as well as those who are HIV- and at-risk for seroconversion, such as injecting-drug and cocaine users and others at risk for seroconversion through sexual contact. The Executive Office of the CPCRA Clinical Trials Unit, located at the Veterans Affairs Medical Center in Washington DC, is an off-campus affiliate of the applicant institution, The George Washington University. The Principal Investigator and Executive Office staff provide oversight, central coordination, training and education, technical assistance, and regulatory support for its 137 clinical research sites, organized by region into 23 Site Coordinating Centers in the United States, Brazil, Canada, Peru, and South Africa. These sites have in care a cumulative, demographically diverse patient base of over 152,000 persons with HIV/AIDS.