Administrative and Scientific Coordination

项目概要（见说明）：行政和科学协调核心提供赠款的整体管理，包括财政，行政和科学责任，并为四个研究项目和P01的四个核心提供综合功能。具体目标包括：（1）提供赠款的行政管理，确保研究的顺利进行;（2）提供赠款的财务管理，包括总体预算和对个别项目和核心项目的拨款;以及3）为赠款提供全面的科学指导，确保研究有效地进行，研究人员参与智力互动，并提供适当的科学审查。与这一目标相关的活动包括编写进度报告，协助编写手稿，监督分包给南加州大学、弗雷德哈钦森癌症研究中心（FHCRC）和布里格姆妇女医院（BWH）的活动，管理通信，IRB确保批准和其他法规合规性，协调项目、核心和实验室之间的活动。与目标2有关的活动包括监测预算和批准支出，与供应商订立分包合同和账户，确保遵守国家癌症研究所和夏威夷大学的财政要求，编制预算，监测工作人员出勤率和工资。与具体目标3相关的活动包括项目和核心研究者的定期和临时会议，在其他科学场所讨论P01研究，外部咨询委员会的访问，与顾问和外部合作者的沟通，以及数据共享计划。核心A将由赠款的主要研究者管理，由一名行政和文书助理协助，由项目和核心的领导人/共同领导人组成的指导委员会定期提供投入。提供共同的管理职能。核心A使研究活动能够有效地进行，确保资源得到有效利用，保持研究之间的协调，并为研究人员提供最大的科学互动，以提高科学水平和速度。

PROJECT SUMMARY (See instructions): The Administrative and Scientific Coordination Core provides for overall administration of the grant, encompassing fiscal, administrative and scientific responsibilities, and serves an integrative function for the four research projects and four cores of the P01. The Specific Aims include: 1) To provide for the administrative management of the grant, assuring the smooth progress of the research; 2) to provide for the fiscal management of the grant, encompassing both the overall budget and allocations to the individual projects and cores; and 3) to provide overall scientific direction to the grant, assuring that the research progresses effectively, that investigators engage in intellectual interactions, and that appropriate review/ of the science are provided. Activities related to this aim include preparation of progress reports, assisting with preparation of manuscripts, overseeing the activities of the subcontracts to the University of Southern California, the Fred Hutchinson Cancer Research Center (FHCRC) and Brigham and Women's Hospital (BWH), managing communications, assuring IRB approvals and other regulatory compliance, coordinating activities among projects, cores and laboratories. Activities related to Aim 2 include monitoring budgets and approving expenditures, setting up sub-contracts and accounts with vendors, assuring compliance with fiscal requirements of NCI and the University of Hawaii, preparing budgets, and monitoring staff attendance and payroll. Activities related to Specific Aim 3 include regular and ad hoc meetings of the project and core investigators, discussions of the P01 research in other scientific venues, visits from an external advisory committee, communication with consultants and external collaborators, and planning for data sharing. Core A will be managed by the PI of the grant, aided by an administrative and clerical assistant, with regular input from a steering committee consisting of the Leaders/Co-Leaders of the Projects and Cores. By providing for common management functions. Core A enables the research activities to proceed effectively, assures that resources are utilized efficiently, maintains coordination among studies, and provides for maximal scientific interactions among the investigators to enhance the level and pace of science.