Training in Cellular and Molecular Imaging of Cancer

项目摘要/摘要 这项申请寻求支持一个新的博士前教育和培训项目 范德比尔特大学和梅哈里医学院的癌症分子成像。中国的生物医学成像 Vivo已经从早期使用X射线进行诊断发展成为一种强大的有用技术大纲 不仅用于病人护理，而且用于在细胞和分子水平上研究基本的生物过程 级别。近年来，各种技术和分子工具已经发展起来，以推动细胞和分子 成像成为癌症研究的前沿。然而，有一个迫切需要的科学家在那里工作 物理科学和生物科学之间的接口能力要得到培训，以便在 癌症的成像和基本生物学过程。我们建议通过全面的 为10名杰出的博士前科学家设计的教学教育和研究培训计划(5年 每两年)。我们将招收最近完成本科学位的实习生 相关科学(特别是生物医学工程、物理、化学、分子生物物理学、电学 工程学或生物学)，将从事癌症分子和/或细胞成像方面的研究。这个 拟议计划的教学部分将包括课程、研讨会和一个日记俱乐部。这个 课程将安排为两个轨道：一个是为那些以前的培训强调相关体能的人 其中一项针对理科专业，另一项针对曾受过相关生物科学培训的人。这两个轨迹通过 第二年结束，以便所有受训人员，无论以前接受过什么培训，都将配备必要的 背景将定量成像和癌症生物学结合在最高水平。所有实习生都将成为 在生物医学研究的伦理方面以及在拨款撰写方面受到指导。此外，说教和说教的 研究训练部分旨在综合物理和生物学科，从而 创建一个独特的多学科和跨学科的癌症研究培训计划。为了这项研究 每名学员将有两名导师，分别代表影像科学和癌症学科 生物学。受训者将被整合到NIH资助的正在进行的研究中，在领先的生物医学成像 在领先的癌症中心拥有强大的人脉和根基的研究所。通过将资源和 范德比尔特大学影像科学研究所(VUIIS)的项目，范德比尔特-英格拉姆癌症 和梅哈里医学院(CCM)的癌症中心，我们相信我们有一个杰出的 基础设施和人员，以创建领先的、示范性的癌症成像培训计划。叙述性 这项申请寻求支持一个新的博士前教育和培训项目 范德比尔特大学和梅哈里医学院的癌症分子成像。中国的生物医学成像 Vivo已经从早期使用X射线进行诊断发展成为一种强大的有用技术大纲 不仅用于病人护理，而且用于在细胞和分子水平上研究基本的生物过程 级别。迫切需要从事物理和生物科学研究的科学家 在癌症的成像和基本生物学过程之间建立联系的能力方面进行培训。

Project Summary/Abstract This application seeks support for a new, pre-doctoral educational and training program in Cellular and Molecular Imaging of Cancer at Vanderbilt University and Meharry Medical College. Biomedical imaging in vivo has developed from early uses of X-rays for diagnosis into a compendium of powerful techniques useful not only for patient care but also for the study of fundamental biological processes at the cellular and molecular levels. A variety of technical and molecular tools have evolved in recent years to propel cellular and molecular imaging into the forefront of cancer research. However, there is a critical need for scientists working at the interface of the physical and biological sciences to be trained in the ability to make the connections between imaging and basic biological processes in cancer. We propose to address this need with a comprehensive didactic educational and research training program designed for 10 outstanding pre-doctoral scientists (5 in each of two years). We will recruit trainees who have recently completed an undergraduate degree in a relevant science (particularly in Biomedical Engineering, Physics, Chemistry, Molecular Biophysics, Electrical Engineering or Biology) who will pursue research focused on molecular and/or cellular imaging of cancer. The didactic component of the proposed program will consist of courses, seminars, and a journal club. The courses will be organized into two tracks: one for those whose prior training emphasized relevant physical sciences and one for those with prior training in relevant biological sciences. The two tracks converge by the end of the second year so that all trainees, regardless of previous training, will be equipped with the necessary background to combine quantitative imaging and cancer biology at the highest levels. All trainees will be mentored in the ethics of biomedical research as well as in grant writing. Furthermore, both the didactic and research training components are designed to synthesize the physical and biological disciplines thereby creating a unique multi- and interdisciplinary training program for the study of cancer. For the research component, each trainee will have two mentors representing the disciplines of imaging science and cancer biology. Trainees will be integrated into ongoing NIH funded investigations within a leading biomedical imaging institute with strong connections and roots within a leading cancer center. By combining the resources and programs of the Vanderbilt University Institute of Imaging Science (VUIIS), the Vanderbilt-Ingram Cancer Center (VICC), and the Cancer Center at Meharry Medical College (CCM), we believe we have an outstanding infrastructure and personnel to create a leading, exemplary training program in cancer imaging. Narrative This application seeks support for a new, pre-doctoral educational and training program in Cellular and Molecular Imaging of Cancer at Vanderbilt University and Meharry Medical College. Biomedical imaging in vivo has developed from early uses of X-rays for diagnosis into a compendium of powerful techniques useful not only for patient care but also for the study of fundamental biological processes at the cellular and molecular levels. There is a critical need for scientists working at the interface of the physical and biological sciences to be trained in the ability to make the connections between imaging and basic biological processes in cancer.