Training in Cellular and Molecular Imaging of Cancer

癌症细胞和分子成像培训

• 批准号: 8507169
• 负责人: John C Gore
• 金额: $ 41.42万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-10 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8507169
• 关键词: Address; Applications Grants; Biological; Biological Process; Biological Sciences; Biology; Biomedical Engineering; Biomedical Research; Biophysics; Cancer Biology; Cancer Center; Chemistry; Competence; Diagnosis; Discipline; Doctor of Philosophy; Educational Curriculum; Educational workshop; Electrical Engineering; Ensure; Ethics; Funding; Goals; Grant; Health; Human Resources; Image; Imaging Techniques; Institutes; Investigation; Journals; Laboratories; Malignant Neoplasms; Mentors; Molecular; Patient Care; Physics; Plant Roots; Publications; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Roentgen Rays; Science; Scientist; Stress; Structure; Techniques; Training; Training Programs; United States National Institutes of Health; Universities; Work; Writing; abstracting; anticancer research; bioimaging; cancer imaging; cellular imaging; design; doctoral student; experience; in vivo; insight; knowledge base; medical schools; molecular/cellular imaging; multidisciplinary; physical science; pre-doctoral; programs; skills; tool

Project Summary/Abstract This application seeks support for a new, pre-doctoral educational and training program in Cellular and Molecular Imaging of Cancer at Vanderbilt University and Meharry Medical College. Biomedical imaging in vivo has developed from early uses of X-rays for diagnosis into a compendium of powerful techniques useful not only for patient care but also for the study of fundamental biological processes at the cellular and molecular levels. A variety of technical and molecular tools have evolved in recent years to propel cellular and molecular imaging into the forefront of cancer research. However, there is a critical need for scientists working at the interface of the physical and biological sciences to be trained in the ability to make the connections between imaging and basic biological processes in cancer. We propose to address this need with a comprehensive didactic educational and research training program designed for 10 outstanding pre-doctoral scientists (5 in each of two years). We will recruit trainees who have recently completed an undergraduate degree in a relevant science (particularly in Biomedical Engineering, Physics, Chemistry, Molecular Biophysics, Electrical Engineering or Biology) who will pursue research focused on molecular and/or cellular imaging of cancer. The didactic component of the proposed program will consist of courses, seminars, and a journal club. The courses will be organized into two tracks: one for those whose prior training emphasized relevant physical sciences and one for those with prior training in relevant biological sciences. The two tracks converge by the end of the second year so that all trainees, regardless of previous training, will be equipped with the necessary background to combine quantitative imaging and cancer biology at the highest levels. All trainees will be mentored in the ethics of biomedical research as well as in grant writing. Furthermore, both the didactic and research training components are designed to synthesize the physical and biological disciplines thereby creating a unique multi- and interdisciplinary training program for the study of cancer. For the research component, each trainee will have two mentors representing the disciplines of imaging science and cancer biology. Trainees will be integrated into ongoing NIH funded investigations within a leading biomedical imaging institute with strong connections and roots within a leading cancer center. By combining the resources and programs of the Vanderbilt University Institute of Imaging Science (VUIIS), the Vanderbilt-Ingram Cancer Center (VICC), and the Cancer Center at Meharry Medical College (CCM), we believe we have an outstanding infrastructure and personnel to create a leading, exemplary training program in cancer imaging. Narrative This application seeks support for a new, pre-doctoral educational and training program in Cellular and Molecular Imaging of Cancer at Vanderbilt University and Meharry Medical College. Biomedical imaging in vivo has developed from early uses of X-rays for diagnosis into a compendium of powerful techniques useful not only for patient care but also for the study of fundamental biological processes at the cellular and molecular levels. There is a critical need for scientists working at the interface of the physical and biological sciences to be trained in the ability to make the connections between imaging and basic biological processes in cancer.

项目总结/摘要 此应用程序寻求支持一个新的，博士前的教育和培训计划的细胞和 范德比尔特大学和梅哈里医学院的癌症分子成像。生物医学成像 vivo已经从早期使用X射线诊断发展成为一个强大的技术纲要， 不仅用于病人护理，而且用于细胞和分子水平上的基本生物过程的研究。 程度.近年来发展了多种技术和分子工具来推动细胞和分子 进入癌症研究的前沿。然而，迫切需要科学家在 物理科学和生物科学的接口，以培养在两者之间建立联系的能力。 成像和癌症的基本生物学过程。我们建议以全面的 教学教育和研究培训计划，为10名优秀的博士前科学家（5人）设计 每两年）。我们将招募最近完成本科学位的学员， 相关科学（特别是生物医学工程，物理学，化学，分子生物物理学，电气 工程或生物学）谁将从事研究集中在癌症的分子和/或细胞成像。的 拟议方案的教学部分将包括课程、研讨会和期刊俱乐部。的 课程将分为两个轨道：一个是为那些以前的培训强调相关的物理 一个是为那些曾接受过相关生物科学培训的人提供的。两条轨道在 第二年年底，以便所有受训人员，无论以前是否受过培训，都将配备必要的 背景技术以最高水平将联合收割机定量成像和癌症生物学相结合。所有学员将 在生物医学研究的伦理学以及赠款写作方面受到指导。此外，教学和 研究训练的组成部分旨在综合物理和生物学科， 为癌症研究创建一个独特的多学科和跨学科的培训计划。为研究 每个学员将有两名导师，分别代表成像科学和癌症学科 生物学受训人员将被纳入正在进行的NIH资助的研究，在一个领先的生物医学成像 研究所与领先的癌症中心有着强大的联系和根基。通过整合资源， 范德比尔特大学成像科学研究所（VUIIS）的项目，范德比尔特-英格拉姆癌症研究所 中心（VICC）和梅哈里医学院（CCM）癌症中心，我们相信我们有一个杰出的 基础设施和人员，以创建一个领先的，示范性的培训计划，在癌症成像。叙事 此应用程序寻求支持一个新的，博士前的教育和培训计划的细胞和 范德比尔特大学和梅哈里医学院的癌症分子成像。生物医学成像 vivo已经从早期使用X射线诊断发展成为一个强大的技术纲要， 不仅用于病人护理，而且用于细胞和分子水平上的基本生物过程的研究。 程度.从事物理科学和生物科学工作的科学家迫切需要 接受在癌症成像和基本生物过程之间建立联系的能力的培训。

项目成果

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging.

比较用于乳腺成像的高纯度锗和碲化镉锌探测器的模拟研究。

• DOI: 10.1088/0031-9155/59/22/7059
• 发表时间: 2014
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Campbell,DL;Peterson,TE
• 通讯作者: Peterson,TE

Accelerated MRI thermometry by direct estimation of temperature from undersampled k-space data.

• DOI: 10.1002/mrm.25327
• 发表时间: 2015-05
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Gaur, Pooja;Grissom, William A.
• 通讯作者: Grissom, William A.

A novel optical approach to intraoperative detection of parathyroid glands.

• DOI: 10.1016/j.surg.2013.06.046
• 发表时间: 2013-12
• 期刊: SURGERY
• 影响因子: 3.8
• 作者: McWade, Melanie A.;Paras, Constantine;White, Lisa M.;Phay, John E.;Mahadevan-Jansen, Anita;Broome, James T.
• 通讯作者: Broome, James T.

XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.

• DOI: 10.1016/j.mri.2014.02.002
• 发表时间: 2014-06
• 期刊: MAGNETIC RESONANCE IMAGING
• 影响因子: 2.5
• 作者: Nikolaou, Panayiotis;Coffey, Aaron M.;Walkup, Laura L.;Gust, Brogan M.;Whiting, Nicholas;Newton, Hayley;Muradyan, Iga;Dabaghyan, Mikayel;Ranta, Kaili;Moroz, Gregory D.;Rosen, Matthew S.;Patz, Samuel;Barlow, Michael J.;Chekmenev, Eduard Y.;Goodson, Boyd M.
• 通讯作者: Goodson, Boyd M.

Photothermal optical lock-in optical coherence tomography for in vivo imaging.

用于体内成像的光热光学锁定光学相干断层扫描。

• DOI: 10.1364/boe.6.002268
• 发表时间: 2015
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Tucker-Schwartz,JasonM;Lapierre-Landry,Maryse;Patil,ChetanA;Skala,MelissaC
• 通讯作者: Skala,MelissaC