Genes in the Predisposition to Papillary Thyroid Carcinoma

甲状腺乳头状癌易感基因

基本信息

  • 批准号:
    8505963
  • 负责人:
  • 金额:
    $ 37.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-03-01 至
  • 项目状态:
    未结题

项目摘要

The broad, long term objective of this project is to reduce morbidity and mortality caused by papillary thyroid carcinoma (PTC) which accounts for - 80% of all thyroid cancer. PTC displays remarl<ably high heritability suggesting the existence of genes that when mutated predispose to PTC. The traditional way of searching for such genes is by linkage analysis in families with multiple affected individuals. Despite vigorous world-wide research this approach has yielded modest results in that only 3 genes have been detected that in all lil<elihood cause PTC, and the total number of individuals affected by these genes is minimal. This has led to the hypothesis that the putative culpable genes are either common but of extremely low effect size (penetrance) or might be of higher penetrance but rare or super rare. Our genome wide association studies (GWAS) have begun to sustain this hypothesis in that several loci with low effect size have been detected. We are focusing on rare higher penetrance genes in families in this Project based on findings from the first cycle of this POl. In particular, a novel type of gene, long intergenic noncoding RNA (lincRNAs) appears to underlie at least some of these susceptibility loci. We are presently applying whole genome sequencing to members of affected families in search of further culpable genes. At least one case of an ultra rare high penetrance gene has been detected in this way, and with improvements in technology this avenue likely will lead to a fuller understanding of the genetic predisposition to PTC.
该项目的长期目标是降低乳头状瘤的发病率和死亡率

项目成果

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ALBERT DE LA CHAPELLE其他文献

ALBERT DE LA CHAPELLE的其他文献

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{{ truncateString('ALBERT DE LA CHAPELLE', 18)}}的其他基金

Low-Penetrance Genes in the Predisposition to Papillary Thyroid Cancer
低外显率基因易患甲状腺乳头状癌
  • 批准号:
    8588543
  • 财政年份:
    2013
  • 资助金额:
    $ 37.82万
  • 项目类别:
Early Predisposing Genes and Risk Stratification for CLL
CLL 的早期易感基因和风险分层
  • 批准号:
    7715167
  • 财政年份:
    2009
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genes in the Predisposition to Papillary Thyroid Carcinoma
甲状腺乳头状癌易感基因
  • 批准号:
    8697753
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genes in the Predisposition to Papillary Thyroid Carcinoma
甲状腺乳头状癌易感基因
  • 批准号:
    9246459
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Microarray
微阵列
  • 批准号:
    7613101
  • 财政年份:
    2005
  • 资助金额:
    $ 37.82万
  • 项目类别:
BAALC in neurogenesis and hematopoiesis
BAALC 在神经发生和造血中的作用
  • 批准号:
    6826614
  • 财政年份:
    2004
  • 资助金额:
    $ 37.82万
  • 项目类别:
Postdoctoral Training in Cancer Genetics
癌症遗传学博士后培训
  • 批准号:
    7487295
  • 财政年份:
    2004
  • 资助金额:
    $ 37.82万
  • 项目类别:
Postdoctoral Training in Cancer Genetics
癌症遗传学博士后培训
  • 批准号:
    8536086
  • 财政年份:
    2004
  • 资助金额:
    $ 37.82万
  • 项目类别:
Postdoctoral Training in Cancer Genetics
癌症遗传学博士后培训
  • 批准号:
    7905209
  • 财政年份:
    2004
  • 资助金额:
    $ 37.82万
  • 项目类别:
Postdoctoral Training in Cancer Genetics
癌症遗传学博士后培训
  • 批准号:
    8298236
  • 财政年份:
    2004
  • 资助金额:
    $ 37.82万
  • 项目类别:

相似海外基金

Long non-coding RNAs in pancreatic cancer
胰腺癌中的长非编码RNA
  • 批准号:
    8758959
  • 财政年份:
    2014
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genetic and Signaling Pathways in Epithelial Thyroid Cancer
上皮性甲状腺癌的遗传和信号通路
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Genetic and Signaling Pathways in Epithelial Thyroid Cancer
上皮性甲状腺癌的遗传和信号通路
  • 批准号:
    9246457
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genetic and Signaling Pathways in Epithelial Thyroid Cancer
上皮性甲状腺癌的遗传和信号通路
  • 批准号:
    9041526
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genetic and Signaling Pathways in Epithelial Thyroid Cancer
上皮性甲状腺癌的遗传和信号通路
  • 批准号:
    8657014
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genes in the Predisposition to Papillary Thyroid Carcinoma
甲状腺乳头状癌易感基因
  • 批准号:
    8697753
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genetic and Signaling Pathways in Epithelial Thyroid Cancer
上皮性甲状腺癌的遗传和信号通路
  • 批准号:
    8476304
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Genes in the Predisposition to Papillary Thyroid Carcinoma
甲状腺乳头状癌易感基因
  • 批准号:
    9246459
  • 财政年份:
    2008
  • 资助金额:
    $ 37.82万
  • 项目类别:
Search for new MODY genes and molecular studies of their function in beta cells
寻找新的 MODY 基因并对其在 β 细胞中的功能进行分子研究
  • 批准号:
    8241894
  • 财政年份:
    1998
  • 资助金额:
    $ 37.82万
  • 项目类别:
Search for new MODY genes and molecular studies of their function in beta cells
寻找新的 MODY 基因并对其在 β 细胞中的功能进行分子研究
  • 批准号:
    8462959
  • 财政年份:
    1998
  • 资助金额:
    $ 37.82万
  • 项目类别:
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