Postdoctoral Training in Cancer Genetics

癌症遗传学博士后培训

• 批准号: 8298236
• 负责人: ALBERT DE LA CHAPELLE
• 金额: $ 44.8万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298236
• 关键词: cancer genetics; post-doctoral training

This is a competitive renewal of an application for postdoctoral training in cancer genetics at the Ohio State University Comprehensive Cancer Center (OSLJCCC). During the first funding period, the Advisory Committee and training faculty quickly realized the many strengths of the training program as well as some of the weaknesses. This application thus represents an evolving concept for training our new genre of cancer researchers that includes several new aspects to the training that we have implemented or plan to implement in the proposed Cancer Genetics Training Program (CG T32). The central theme and strength of the training program of having basic/translational co-mentoring of trainees in three cancer sites remains intact. Forty scientists at the OSUCCC will join forces to train the next generation of cancer geneticists, with an emphasis on multidisciplinary approaches to the study and treatment of breast, gastro-intestinal and hematopoietic cancers. We will use unique recruiting tools that were proven extraordinarily successful in the last funding period to attract and/or retain eight talented postdoctoral candidates each year of the program. Recognizing that a complete understanding of the basic mechanisms of cancer initiation and progression will be required for the efficient translation of knowledge to the treatment of patients, the training program has compiled a balanced group of investigators with expertise in genetics, cell signaling, cell biology and tumor models, and with an intense interest and a proven record in translational research. The commitment to coupling basic knowledge to translational and/or clinical research will continue to be realized by providing trainees with two co-mentors with strengths in basic and translational research and having divergent expertise, bridging the gap between these two areas. The main new aspects of the training program include 1. an annual postdoctoral symposium series, 2. a grant writing workshop that will be specific to each trainee and guide/evaluate applications aimed to help them transition into independent research positions (NIHK99/ROO, K01 or similar grants), and 3. the addition of new training faculty with strengths in translational and/or clinical cancer research. By maintaining the original strengths and focus of the CG T32 program and implementing novel targeted training approaches, the proposed training program will create a unique setting that strongly encourages basic scientists to venture into translational/clinical research. RELEVANCE (See instructions!: Given the enormous gain of basic knowledge about the biology of cancer in recent years and the palpable excitement in cancer therapeutics, we feel an obligation to retool our strategies of training future cancer researchers to meet the expectation of eventually - sooner rather than later - eradicating cancer from society. We believe that this training program will help to also enhance the extensive ongoing collaborative studies that already exist between training faculty and foster further intellectual and practical exchange of basic and translational concepts to cancer genetics research.

这是俄亥俄大学癌症遗传学博士后培训申请的竞争性更新 国立大学综合癌症中心(OSLJCCC)。在第一个资助期内，咨询 委员会和培训人员很快意识到培训计划的许多优点以及一些 其中的弱点。因此，该应用程序代表了一种不断发展的概念，用于培训我们的新流派 癌症研究人员，包括我们已经实施或计划实施的培训的几个新方面 在拟议的癌症遗传学培训计划(CG T32)中实施。 基础/翻译共同指导的培训计划的中心主题和优势 三个癌症地点的受训人员仍然完好无损。OSUCCC的40名科学家将联手培训下一位 一代癌症遗传学家，强调多学科方法的研究和 乳腺癌、胃肠癌和造血癌的治疗。我们将使用独特的招聘工具 在上一个资助期证明非常成功地吸引和/或留住了八名有才华的人 每年该项目的博士后候选人。认识到对基本知识的全面理解 癌症发生和发展的机制将需要有效地将知识转化为 在患者的治疗方面，培训方案汇集了一支具有专业知识的平衡的调查人员小组 在遗传学、细胞信号、细胞生物学和肿瘤模型方面，并对以下领域有浓厚的兴趣和已证实的记录 翻译研究。致力于将基础知识与翻译和/或临床相结合 将继续通过为学员提供两名共同导师来实现研究，这些导师在基础和 翻译研究和拥有不同的专业知识，弥合了这两个领域之间的差距。 培训计划的主要新方面包括：1.年度博士后研讨会系列；2.a. 批准针对每个学员的写作研讨会，并指导/评估旨在帮助的应用程序 他们过渡到独立研究职位(NIHK99/Roo，K01或类似的补助金)，以及3. 增加在翻译和/或临床癌症研究方面具有优势的新培训教师。通过维护 CG T32计划的原有优势和重点以及实施新的有针对性的培训 方法，拟议的培训方案将创造一个独特的环境，大力鼓励基本的 科学家们冒险进入转译/临床研究。 相关性(参见说明！)： 鉴于近年来关于癌症生物学的基本知识的巨大收获和明显的 在癌症治疗的兴奋中，我们感到有义务重新调整我们培训未来癌症的策略 研究人员希望实现最终--越早越好--根除癌症的期望 社会。我们相信，这一培训计划也将有助于加强正在进行的广泛合作 培训教员之间已经存在的研究，并促进进一步的智力和实践交流 癌症遗传学研究的基本概念和翻译概念。