Postdoctoral Training in Cancer Genetics

这是俄亥俄州癌症遗传学博士后培训申请的竞争性更新 州立大学综合癌症中心。在第一个供资期间，咨询委员会 委员会和培训教师很快意识到培训计划的许多优势，以及一些 的弱点。因此，这个应用程序代表了一个不断发展的概念，用于训练我们的新流派， 癌症研究人员，包括我们已经实施或计划实施的培训的几个新方面， 在拟议的癌症遗传学培训计划（CG T32）实施。 培训计划的中心主题和优势是进行基本/翻译共同指导， 三个癌症部位的受训人员仍然完好无损。OSUCCC的40名科学家将联手培养下一个 一代癌症遗传学家，重点是多学科的研究方法， 治疗乳腺癌、胃肠癌和造血系统癌。我们将使用独特的招聘工具， 在上一个资助期内，成功地吸引和/或留住了8名优秀的 博士后候选人每年的计划。认识到全面了解基本的 癌症发生和发展的机制将需要知识的有效翻译， 治疗病人，培训计划编制了一个平衡的调查小组的专业知识， 在遗传学，细胞信号，细胞生物学和肿瘤模型，并与强烈的兴趣和证明记录， 翻译研究致力于将基础知识与翻译和/或临床知识相结合 研究将继续通过为学员提供两名共同导师来实现， 翻译研究和具有不同的专业知识，弥合这两个领域之间的差距。 培训计划的主要新方面包括1.年度博士后研讨会系列，2。一 赠款写作研讨会，将具体到每个学员和指导/评估申请，旨在帮助 他们过渡到独立的研究职位（NIHK 99/ROO，K 01或类似的赠款），和3。的 增加新的培训教师，在转化和/或临床癌症研究方面具有优势。通过保持 CG T32计划的原始优势和重点，并实施新的针对性培训 方法，拟议的培训计划将创造一个独特的环境，强烈鼓励基本的 科学家冒险进入转化/临床研究。 相关性（参见说明！： 考虑到近年来癌症生物学基础知识的巨大收获以及 癌症治疗的兴奋，我们觉得有义务重新调整我们的战略， 研究人员，以满足最终的期望-早，而不是晚-根除癌症， 社会我们相信，这项培训计划将有助于加强正在进行的广泛合作， 培训教师之间已经存在的研究，并促进进一步的知识和实践交流， 癌症遗传学研究的基本和转化概念。

This is a competitive renewal of an application for postdoctoral training in cancer genetics at the Ohio State University Comprehensive Cancer Center (OSLJCCC). During the first funding period, the Advisory Committee and training faculty quickly realized the many strengths of the training program as well as some of the weaknesses. This application thus represents an evolving concept for training our new genre of cancer researchers that includes several new aspects to the training that we have implemented or plan to implement in the proposed Cancer Genetics Training Program (CG T32). The central theme and strength of the training program of having basic/translational co-mentoring of trainees in three cancer sites remains intact. Forty scientists at the OSUCCC will join forces to train the next generation of cancer geneticists, with an emphasis on multidisciplinary approaches to the study and treatment of breast, gastro-intestinal and hematopoietic cancers. We will use unique recruiting tools that were proven extraordinarily successful in the last funding period to attract and/or retain eight talented postdoctoral candidates each year of the program. Recognizing that a complete understanding of the basic mechanisms of cancer initiation and progression will be required for the efficient translation of knowledge to the treatment of patients, the training program has compiled a balanced group of investigators with expertise in genetics, cell signaling, cell biology and tumor models, and with an intense interest and a proven record in translational research. The commitment to coupling basic knowledge to translational and/or clinical research will continue to be realized by providing trainees with two co-mentors with strengths in basic and translational research and having divergent expertise, bridging the gap between these two areas. The main new aspects of the training program include 1. an annual postdoctoral symposium series, 2. a grant writing workshop that will be specific to each trainee and guide/evaluate applications aimed to help them transition into independent research positions (NIHK99/ROO, K01 or similar grants), and 3. the addition of new training faculty with strengths in translational and/or clinical cancer research. By maintaining the original strengths and focus of the CG T32 program and implementing novel targeted training approaches, the proposed training program will create a unique setting that strongly encourages basic scientists to venture into translational/clinical research. RELEVANCE (See instructions!: Given the enormous gain of basic knowledge about the biology of cancer in recent years and the palpable excitement in cancer therapeutics, we feel an obligation to retool our strategies of training future cancer researchers to meet the expectation of eventually - sooner rather than later - eradicating cancer from society. We believe that this training program will help to also enhance the extensive ongoing collaborative studies that already exist between training faculty and foster further intellectual and practical exchange of basic and translational concepts to cancer genetics research.