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Role of brown adipose tissue (BAT) in energy balance

Role of brown adipose tissue (BAT) in energy balance
棕色脂肪组织（BAT）在能量平衡中的作用
批准号：
8741604
负责人：
MARC L REITMAN
金额：
$28.01万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8741604
关键词：
AdultBody TemperatureBody WeightBrown FatComorbidityDietFatty acid glycerol estersGoalsHomeostasisInsulin ResistanceMusNatureObesityRegulationRodentRoleTissuesWeight Gaindesignenergy balanceinterestresearch study

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中文摘要
翻译
虽然BAT在维持体温中的作用是明确的，但BAT对体重调节的作用尚未得到很好的理解。Rothwell和Stock （Nature, 1979）的研究表明，过度给啮齿动物喂食高脂肪食物会刺激BAT，这表明BAT在限制体重增加方面发挥了作用。然而，BAT具有此功能的想法远未被普遍接受。
英文摘要
While the role of BAT in maintaining body temperature is unambiguous, BATs contribution to body weight regulation is not well understood. Rothwell and Stock (Nature, 1979) showed that overfeeding rodents a high fat diet stimulated BAT, suggesting a role for BAT in limiting weight gain. However, the idea that BAT has this function is far from universally accepted. Experiments are now being designed and others underway using mice to examine the contribution of BAT to regulation of body weight (and adiposity) and insulin resistance.
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