NIAMS Multidisciplinary Clinical Research Center

拟议的UCSF多学科临床研究中心计划（UCSF MCRC）的广泛目标是通过发现影响这些结果的医学，人口统计学和背景因素来改善患有各种形式风湿性疾病的人的结果。这一总体目标是通过风湿性疾病临床研究的综合计划来实现的，包括但不限于MCRC内的临床研究;通过在整个UCSF中作为此类临床研究的催化剂;以及通过对风湿性疾病临床研究人员的系统培训。 MCRC包括一个行政单位，方法核心，四个五年期项目和一个三年期发展和可行性研究（D&F）。MCRC的参与者跨越三个UCSF学校（医学，护理和牙科）和加州大学戴维斯分校，包括九个独立学术单位的代表，包括UCSF GCRC。该中心的主任和副主任分别是爱德华·叶林博士和林赛·克里斯韦尔博士。核心股主任是帕特里夏·卡茨博士。该委员会的日常活动由一个执行委员会指导。该中心的战略监督由内部（UCSF）和外部咨询委员会提供。该中心还将有一个导师 毕业生理事会是由我们最资深的前学员组成的委员会，他们现在都在加州大学旧金山分校和其他三所医学院从事学术医学工作。 MCRC的研究是基于对系统性红斑狼疮（SLE）和类风湿性关节炎（RA）两种特定疾病的纵向原始数据的分析。主要数据，狼疮结局研究和风湿性关节炎结局研究，在MCRC项目中共享。这两个数据集的设计和实施由方法核心股负责。核心部门还负责生物统计咨询以及对教师和研究员进行新兴分析方法的指导。 具体的五年项目是：项目1：遗传学、遗传学和SLE结果（Lindsey Criswell，P.I.）;项目2：肥胖和体力活动对RA和SLE抑郁的影响（Patricia Katz，P.I.）;和项目3：影响SLE易感人群结局的卫生保健因素（Edward Yelin，P.I.）。D&F研究是：开发定制的症状评估工具，以加强以患者为中心的RA护理（Jennifer巴顿，P.I.）。

The broad aim of the proposed UCSF Multidisciplinary Clinical Research Center Program (UCSF MCRC) is to improve outcomes for persons with various forms of rheumatic diseases by discovery of the medical, demographic, and contextual factors affecting those outcomes. This overarching aim is pursued by a comprehensive program of clinical research in the rheumatic diseases, including but not limited to that within the MCRC; by serving as a catalyst for such clinical research throughout UCSF; and by systematic training of clinical investigators in the rheumatic diseases. The MCRC consists of an Administrative Unit, Methodology Core, four five-year projects, and a three-year Development and Feasibility (D&F) Study. The participants in the MCRC span three UCSF schools (Medicine, Nursing, and Dentistry) and UC, Davis and include representatives of nine discrete academic units, including the UCSF GCRC. The Center's Director and Associate Director are Drs. Edward Yelin and Lindsey Criswell, respectively. The Director of the Core Unit is Dr. Patricia Katz. The activities of the MCRC are guided on a day-to-day basis by an Executive Committee. Strategic oversight of the Center is provided by Internal (UCSF) and External Advisory Committees. The Center will also have a mentorship committee of our most senior former trainees, now all in academic medicine at UCSF and three other medical schools, the Graduates' Council. The research of the MCRC is based on analysis of longitudinal primary data about two specific diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The primary data, the Lupus Outcomes Study, and the Rheumatoid Arthritis Outcomes Study, are shared across MCRC projects. Design and implementation of these two datasets occurs in the Methodology Core Unit. The Core Unit is also repsonsible for biostatistical consulting and mentorship of faculty and fellows in emerging methods of analysis. The specific five-year projects are: Project 1: Genetics, Ancestry, and SLE Outcomes (Lindsey Criswell, P.I); Project 2: The Impact of Obesity and Physical Activity on Depression in RA and SLE (Patricia Katz, P.I.); and Project 3: Health Care Factors Affecting Outcomes of Vulnerable Populations with SLE (Edward Yelin, P.I.). The D&F Study is: The Development of a Tailored Symptom Assessment Tool to Enhance Patient-Centered Care in RA (Jennifer Barton, P.I.).