Direct physiological assessment of the BOLD calibration methods
BOLD 校准方法的直接生理评估
基本信息
- 批准号:8465932
- 负责人:
- 金额:$ 18.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-06-01 至 2015-05-31
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimalsBloodBlood VesselsBlood VolumeBrainBrain MappingBreathingCalibrationCarbon DioxideCerebrovascular CirculationCerebrumClinicalDiagnosisDiseaseError SourcesFunctional Magnetic Resonance ImagingGasesGoalsGoldHealthHumanHypercapniaHyperoxiaInvestigationLaser Scanning MicroscopyLaser-Doppler FlowmetryLawsLeadMeasurementMeasuresMetabolicMethodsMicroelectrodesModelingOutcomeOxygenOxygen measurement, partial pressure, arterialPhysiologicalProceduresPublic HealthResearchStimulusStrokeTechniquesTestingTissuesVenousWorkbaseblood flow measurementblood oxygen level dependentinnovationnervous system disorderneural stimulationneurophysiologypatient populationrelating to nervous systemresponsesensortreatment planningtumortwo-photon
项目摘要
DESCRIPTION (provided by applicant): Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used for non-invasively mapping brain function in research and clinical settings. In contrast, quantitative BOLD fMRI approaches have not completely fulfilled their research and clinical potentials because important and unverified concerns remain regarding the appropriateness and accuracy of the calibration procedure. The objective in this particular application is to examine unverified central assumptions used in the BOLD calibration procedures: 1) CO2 and O2 challenges used for calibration do not alter a cerebral metabolic rate of oxygen (CMRO2) and 2) the changes in cerebral blood volume (CBV), especially venous CBV, are directly related to the changes in cerebral blood flow (CBF) induced by CO2 and O2 challenges. To attain this objective we will use well- established techniques to directly determine the following parameters: 1) ongoing neural activity, vascular oxygen concentration and CBF changes induced by CO2 and O2 challenges for CMR O2 estimates, and 2) changes in CBF and venous CBV induced by CO2 and O2 challenges as well as by neural stimulation to examine the relationship between CBV and CBF. The rationale for the proposed research is that the quantitative assessment of BOLD fMRI requires more comprehensive investigations of CO2 or O2-induced changes in vascular and metabolic neurophysiology. Once the CO2 and O2 challenges are validated as iso- metabolic stimuli and the relationship between venous CBV and CBF is established, these calibration strategies will be readily applicable for the accurate assessment of human brain function in the research and clinical settings. This approach is innovative because it provides a direct and more comprehensive assessment of unverified assumptions for BOLD calibration. The proposed research is significant because it could ultimately lead to the advancement of quantitative fMRI, including CMRO2 estimates, in the diagnosis and treatment planning of diseases that are associated with tumor, stroke and neurological disorders.
描述(由申请人提供):血氧水平依赖(BOLD)功能磁共振成像(fMRI)广泛用于研究和临床环境中的非侵入性脑功能标测。相比之下,定量BOLD功能磁共振成像方法还没有完全实现其研究和临床潜力,因为重要的和未经验证的关注仍然关于校准程序的适当性和准确性。该特定应用的目的是检查BOLD校准程序中使用的未经验证的中心假设:1)用于校准的CO2和O2激发不会改变脑氧代谢率(CMRO 2),2)脑血容量(CBV)的变化,特别是静脉CBV,与CO2和O2激发诱导的脑血流量(CBF)变化直接相关。为了实现这一目标,我们将使用成熟的技术直接确定以下参数:1)由CO2和O2激发诱导的持续神经活动、血管氧浓度和CBF变化,用于CMR O2估计,以及2)由CO2和O2激发以及神经刺激诱导的CBF和静脉CBV变化,以检查CBV和CBF之间的关系。拟议研究的基本原理是,BOLD功能磁共振成像的定量评估需要更全面的调查CO2或O2引起的血管和代谢神经生理学的变化。一旦CO2和O2挑战被确认为等代谢刺激,并且静脉CBV和CBF之间的关系被建立,这些校准策略将很容易适用于在研究和临床环境中准确评估人脑功能。这种方法是创新的,因为它提供了一个直接和更全面的评估未经验证的假设BOLD校准。这项研究意义重大,因为它最终可能导致定量fMRI的进步,包括CMRO2估计,用于与肿瘤,中风和神经系统疾病相关的疾病的诊断和治疗计划。
项目成果
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MITSUHIRO FUKUDA其他文献
MITSUHIRO FUKUDA的其他文献
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{{ truncateString('MITSUHIRO FUKUDA', 18)}}的其他基金
Direct physiological assessment of the BOLD calibration methods
BOLD 校准方法的直接生理评估
- 批准号:
8282285 - 财政年份:2012
- 资助金额:
$ 18.27万 - 项目类别:
Fast Optical Imaging with Flavoprotein Autofluorescence in Visual Cortex
视觉皮层中黄素蛋白自发荧光的快速光学成像
- 批准号:
7286816 - 财政年份:2006
- 资助金额:
$ 18.27万 - 项目类别:
Fast Optical Imaging with Flavoprotein Autofluorescence in Visual Cortex
视觉皮层中黄素蛋白自发荧光的快速光学成像
- 批准号:
7139473 - 财政年份:2006
- 资助金额:
$ 18.27万 - 项目类别:
Neurovascular Mechanisms of Layer-specific fMRI
层特异性功能磁共振成像的神经血管机制
- 批准号:
9770845 - 财政年份:2000
- 资助金额:
$ 18.27万 - 项目类别:
Neurovascular Mechanisms of Layer-specific fMRI
层特异性功能磁共振成像的神经血管机制
- 批准号:
9346639 - 财政年份:2000
- 资助金额:
$ 18.27万 - 项目类别:
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