Investigating the utility of therapeutic drug monitoring of beta-lactam antibiotics in hospitalised patients

住院患者的适当抗生素剂量是基于对健康志愿者或可能患有不同类型感染的患者进行的研究得出的广泛指南。患者临床状态的微小变化可能需要显著的剂量调整。确保适当抗生素治疗的最佳方法是根据血药浓度数据制定个体化剂量。我们的目的是确定住院患者剂量调整的效用。

The appropriate dosing of antibiotics for patients admitted to hospital is based on broad guidelines derived from studies in healthy volunteers or in patients that may have different types of infections. Minor changes in the clinical state of the patients can require significant dosing adjustments. The best way to guarantee appropriate antibiotic therapy is to individualize doses based on blood concentration data. We aim to determine the utility of dose adjustment in hospitalized patients.