Robust antibiotic dosing for critically ill patients receiving renal replacement therapy

接受肾脏替代治疗的危重患者的强力抗生素剂量

• 批准号: nhmrc : 1044941
• 负责人: Prof Jason Roberts
• 金额: $ 71.3万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/robust-antibiotic-dosing-replacement-therapy/111701
• 关键词: Robust; antibiotic; dosing; critically; ill

Intensive Care patients more often than not, develop kidney failure requiring dialysis. Unfortunately there is little information available to inform clinicians of appropriate doses for antibiotics in these patients, putting them at an increased risk of death from ineffective treatment. Our project aims to develop dosing guidelines for the many types of dialysis used globally to achieve concentrations in the blood that optimise antibiotic effects in these most critically ill patients.

重症监护病人往往会出现肾衰竭，需要透析。不幸的是，很少有信息可以告诉临床医生这些患者的适当抗生素剂量，使他们因无效治疗而死亡的风险增加。我们的项目旨在为全球使用的多种透析制定剂量指南，以达到血液中的浓度，从而优化这些最危重患者的抗生素效果。