Redefining antibiotic dosing to reduce bacterial resistance

>每年有3000名澳大利亚人死于严重感染（几乎是我们每年道路收费的3倍）。这些治疗失败是由于对这些患者中浓度不同的原因缺乏了解而导致的次优抗生素剂量。我将使用我的实验室来定义我们需要达到的抗生素浓度，并与我的合作网络进行临床研究，以证明我们可以重新定义抗生素剂量，以减少超级细菌的出现。

>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs.