Antibiotic optimisation for severely ill patients

抗生素治疗无效与重症监护病房(ICU)感染患者死亡率增加有关。早期使用有效的抗生素治疗可显著提高存活率。这项工作试图扩展我之前的研究，这些研究描述了ICU患者和非ICU患者之间不同浓度的抗生素。预测何时改变ICU患者的抗生素剂量可能会显著改善患者的预后。

Ineffective antibiotic therapy is associated with increased mortality in infected patients in the intensive care unit (ICU). Early administration of efficacious antibiotic therapy improves survival substantially. This work seeks to extend upon my previous studies that have described the different concentrations of antibiotics between ICU patients and non-ICU patients. Predicting when to change antibiotic doses in ICU patients is likely to substantially improve patient outcomes.