Prevention of mosquito-borne illness through manipulation of the CO2 receptor
通过操纵 CO2 受体预防蚊媒疾病
基本信息
- 批准号:8453734
- 负责人:
- 金额:$ 18.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-18 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:AlgorithmsAreaBedsBehaviorBehavioral AssayBiological AssayBloodCaliforniaCarbon DioxideCessation of lifeChemicalsCountryCuesCulicidaeDetectionDevelopmentDiseaseDoseElectronicsElectrophysiology (science)Environmental WindExhalationFDA approvedFaceFemaleFlavoringGoalsHandHealthHeatingHumanIndividualIndustryInsecticidesLaboratoriesLegal patentLibrariesLicensingMalariaMarketingMasksMethodsMosquito-borne infectious diseaseMutationNatureOdorsPathway interactionsPerceptionPermethrinPhasePlayPopulationPreventionProtocols documentationRecommendationRegulationReportingResearch PersonnelResistanceResistance developmentRoleSafetySkinSolventsSourceTechnologyTestingTimeTimeLineToxic effectTubeUnited StatesUniversitiesWorkbasebehavior testcarbon dioxide receptorcombatcommercializationdensitydisorder preventionexposed human populationinhibitor/antagonistkillingsland usenovelpreventpublic health relevancepyrethroidscreeningsmall moleculetoolvector control
项目摘要
DESCRIPTION (provided by applicant): A key component to combating mosquito-borne illnesses is prevention from acquiring the disease. Current mosquito repellents, such as Permethrin and DEET, have been shown to be too costly and mosquitoes can eventually develop resistance to them. In this proposal, Olfactor Laboratories Inc. (OLI) supports the development of novel, spatial, non-insecticidal mosquito repellents for commercial and residential use around the world. Based upon the work of Dr. Anandasankar Ray of the University of California, Riverside (UCR), who demonstrated that the highly conserved carbon dioxide receptor in mosquitoes can be activated or inhibited by small molecules, OLI has identified over 80 molecules which have been approved for use by the FDA for use as flavors and fragrances that activate or inhibit the CO2 receptor, the primary host- seeking mechanism for mosquitoes. Through prolonged activation or inhibition of the carbon dioxide receptor, we will be able to provide repellency since mosquitoes will not be able to locate CO2 emissions from humans for a blood meal. With this suite of safe, carbon dioxide receptor activators and inhibitors, we are ready to begin behavioral testing in small area and flight assays. Apart from serving as a long-range attraction cue, CO2 has been shown to sensitize mosquitoes to skin odors and using small-area landing assays, we will be able to determine efficacy of the compounds when skin odor is present. Another key assay will be the flight assays, consisting of pre-exposure and co-exposure flight assays. Pre-exposure assays will help determine dose-dependent and duration efficacy while co-exposure flight assays will determine repellency when in direct competition with CO2. Individual odors or blends of odors with a repellency of at least 80% will proceed to Phase II testing which will include large observation chambers and semi-field trials. Through this work, we will be able to develop active ingredients for use in novel, spatial, non-insecticidal mosquito repellents to provide an important new tool for disease prevention.
描述(由申请人提供):防治蚊媒疾病的一个关键组成部分是预防感染该疾病。目前的驱蚊剂,如氯菊酯和避蚊胺,已经被证明过于昂贵,蚊子最终会对它们产生抗药性。在这个提案中,Olfactor Laboratories Inc. (OLI)支持在世界各地开发用于商业和住宅的新型、空间、非杀虫驱蚊剂。加州大学河西分校(UCR)的Anandasankar Ray博士证明,蚊子体内高度保守的二氧化碳受体可以被小分子激活或抑制,OLI已经确定了80多种分子,这些分子已被FDA批准用于香料和香水,可以激活或抑制二氧化碳受体,这是蚊子寻找宿主的主要机制。通过长时间激活或抑制二氧化碳受体,我们将能够提供驱虫剂,因为蚊子将无法定位人类血液中的二氧化碳排放。有了这套安全的二氧化碳受体激活剂和抑制剂,我们准备开始在小区域和飞行试验中进行行为测试。除了作为远距离吸引线索,二氧化碳已被证明对蚊子的皮肤气味敏感,使用小面积着陆试验,我们将能够确定当皮肤气味存在时化合物的功效。另一个关键试验将是飞行试验,包括暴露前和共暴露飞行试验。暴露前试验将有助于确定剂量依赖性和持续时间的有效性,而共暴露飞行试验将确定与二氧化碳直接竞争时的驱避性。驱避率至少为80%的单个气味或混合气味将进入第二阶段测试,其中包括大型观察室和半现场试验。通过这项工作,我们将能够开发出用于新型、空间、非杀虫驱蚊剂的有效成分,为疾病预防提供重要的新工具。
项目成果
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