Child Health Career Development Program at UCSF

描述(由申请人提供)：本修订提案是为了响应RFA-HD-13-011，儿童健康研究职业发展奖(CHRCDA)计划，通过CHRCDA机制向年轻的儿科研究人员提供K12奖项。该申请申请每年支持四名儿科医生，他们拥有医学博士或医学博士学位，并已完成临床分专业的奖学金培训。该计划的理由是，有充分的文件和迫切需要支持儿科医生在指导下的职业发展，使他们能够成为完全独立和富有成效的基础科学研究人员，而且加州大学旧金山分校拥有培养下一代儿科科学领导者的远见、经验和基础设施。我们的目标是(1)为学术儿科医生提供有组织的培训计划，(2)促进职业发展和促进初级教师的保留，(3)让有前途的早期职业儿科医生接触加州大学旧金山分校丰富的学术研究和(4)促进学术儿科的多样性。由该项目培训的学者将带来最先进的方法来诊断、治疗和预防儿童健康问题以及儿童成人疾病的发病。该计划的设计涉及利用世界级基础实验室科学家的专业知识，他们将担任跨学科培训的导师。基础科学培训计划围绕七个科学核心：癌症、心肺医学、发育生物学、遗传学、免疫学、神经生物学和干细胞生物学。每个核心都有一名主任、指定的教员和特定的教学课程。这些学者还将与他们的导师和核心主任一起参加一个额外的特定学科的课程工作计划，这取决于申请者的先前经验和培训以及受训者研究的科学主题，这些主题可能在不同的核心之间经常重叠。我们相信，加州大学旧金山分校的儿科系拥有培养下一代学术儿科领导者的远见、经验和基础设施。在这份申请中，我们提供的证据表明，该部门与加州大学旧金山分校更广泛的研究社区一起，为培养年轻的儿科医生提供了一个特殊的环境，他们将通过CHRCDA机制获得支持，成为成功的基础科学研究人员。例如，加州大学旧金山分校有1000多个研究实验室和2200多个正在进行的研究项目，教职员工目前包括4名诺贝尔奖获得者、41名国家科学院成员、61名美国艺术与科学学院成员、72名医学研究所成员和16名霍华德·休斯医学研究所的研究人员。这项计划是对儿童健康未来的投资，因为 我们将培训的一组研究人员将利用先进的研究策略来解决紧急问题(例如哮喘、癌症、传染病、宿主防御缺陷、糖尿病、肥胖和心脏、大脑和其他器官的发育畸形)，这将导致新的治疗方法来改善儿童的健康结果。

DESCRIPTION (provided by applicant): This revised proposal is submitted in response to RFA-HD-13-011, Child Health Research Career Development Award (CHRCDA) Program to provide K12 awards through the CHRCDA mechanism to young pediatric investigators. The application requests resources to support four pediatricians each year who hold MD or MD/PhD degrees and have completed scholarship training in a clinical subspecialty. The rationale for the program is based on the well-documented and urgent need to support mentored career development for pediatricians to enable them to become fully independent and productive basic science researchers, and the fact that UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science. Our aims are to (1) offer a structured program for training academic pediatricians, (2) foster career development and promote retention of junior faculty, (3) expose promising early career pediatricians to the intellectual richness of UCSF research and (4) promote diversity in academic pediatrics. The scholars trained by this program will bring state-of-the-art approaches to bear on diagnosis, treatment and prevention of health problems in children as well as childhood onset of adult illness. The design of this program involves harnessing the expertise of world-class basic laboratory scientists who will serve as mentors for interdisciplinary training. The basic science training program is focused around seven scientific cores: cancer, cardiopulmonary medicine, developmental biology, genetics, immunology, neurobiology, and stem cell biology. Each core has a Director, designated faculty, and a specific didactic curriculum. The scholars, in conjunction with their mentor and Core Director, will also participate in a program of additional discipline-specific course work dependent on both the prior experience and training of the applicant and the scientific theme of the trainee's research, which may often overlap amongst different cores. We believe that the Department of Pediatrics at UCSF has the vision, experience, and infrastructure to train the next generation of leaders in academic pediatrics. In this application, we provide evidence that the Department together with the broader UCSF research community comprise an exceptional environment for preparing young pediatricians who will receive support through the CHRCDA mechanism for successful careers as basic science researchers. For example, there are over 1,000 research laboratories and over 2,200 active research projects at UCSF, and the faculty currently includes 4 Nobel laureates, 41 National Academy of Sciences members, 61 American Academy of Arts and Sciences members, 72 Institute of Medicine members, and 16 Investigators of the Howard Hughes Medical Institute. This program is an investment in the future of children's health, as the diverse group of researchers we will train will harness advanced research strategies to address urgent problems (e.g., asthma, cancer, infectious diseases, host defense defects, diabetes, obesity, and developmental malformations of the heart, brain, and other organs), that will result in new treatments to improve child health outcomes.