Repair after Neonatal Brain Injury

新生儿脑损伤后的修复

• 批准号: 8883809
• 负责人: Donna M. Ferriero
• 金额: $ 7.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8883809
• 关键词: 10 year old; Adjuvant Therapy; Affect; Age; Animals; Apoptotic; Area; Basal Ganglia; Birth; Brain; Brain Injuries; Cell Death; Cell Death Process; Cells; Child; Chronic; Clinical; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Energy Metabolism; Ensure; Erythropoietin; Event; Evolution; Failure; Grant; Hour; Human; Hybrids; Hypoxia; Image; Imaging Techniques; Impairment; Incidence; Infant; Infection; Inflammation; Injury; Intervention; Investigation; Ischemia; Learning; Length; Life; Magnetic Resonance; Magnetic Resonance Imaging; Metabolic; Metabolism; Methods; Metric; Monitor; Natural regeneration; Necrosis; Neonatal; Neonatal Brain Injury; Nerve Regeneration; Neurons; Newborn Infant; Outcome; Patients; Pattern; Perfusion; Perinatal; Phase; Population; Premature Birth; Premature Infant; Prevalence; Process; Recovery; Research Personnel; Rodent; Scanning; Services; Severities; Spin Labels; Staging; Standardization; Study Subject; Testing; Therapeutic; Therapeutic Effect; Time; Training; Treatment Effectiveness; Visit; White Matter Disease; brain repair; cell injury; cohort; congenital heart disorder; data management; follow-up; functional outcomes; high risk; improved; intervention effect; natural hypothermia; neonate; neurobehavior; neurobehavioral test; novel; programs; public health relevance; repaired; response; response to injury; white matter

DESCRIPTION (provided by applicant): This grant proposes to study both structural and functional correlates of brain developmental maturation and network organization using advanced imaging techniques in our human populations and similar correlates in newborn rodents with a focus on defining basic mechanisms of repair. The grant will encompass three projects and two cores: Project I) repair after ischemic injury in the term newborn - using both structural and metabolic serial imaging to evaluate how the injuries have altered the brain, its response to injury in the perinatal period, and how structural connectivity relates to neurodevelopmental outcome. This cohort will include babies treated with hypothermia. Project II) repair in high risk newborns with congenital heart disease- there is delayed brain development in this high risk population. Using structural and metabolic imaging, we will determine whether this disorder of development is associated with abnormalities in brain connectivity and functional outcome. Project III) repair after early preterm birth - our data show many preterm infants to have abnormalities of cerebellar maturation, abnormalities of white matter development or progressive white matter disease with infection. Using structural and metabolic imaging, we will determine whether altered patterns of connectivity are consistent or variable, whether recovery from these insults is possible and whether connectivity is permanently or transiently disrupted by these early ex-utero life events. There is an administrative Core for data management including biostatistical support, budgetary oversight, training and seminars. The Imaging and Neurobehavior Core (Services Core) will support the three human imaging projects by ensuring standardization of methods and tracking of imaging acquisition at the various testing time points. In addition, this Core will provide Neurobehavioral testing at all of the follow-up visits, and will be responsible for tracking patients for all projets.

描述（由申请人提供）：该基金建议使用先进的成像技术在我们的人类群体中研究大脑发育成熟和网络组织的结构和功能相关性，并在新生啮齿动物中研究类似的相关性，重点是定义基本的修复机制。该补助金将包括三个项目和两个核心：项目I）新生儿缺血性损伤后的修复-使用结构和代谢系列成像来评估损伤如何改变大脑，其对围产期损伤的反应，以及结构连接如何与神经发育结果相关。这个队列将包括接受低温治疗的婴儿。项目II）患有先天性心脏病的高危新生儿的修复-在这个高危人群中，大脑发育迟缓。使用结构和代谢成像，我们将确定这种发育障碍是否与大脑连接和功能结果异常有关。项目III）早期早产后的修复-我们的数据显示许多早产儿有小脑成熟异常、白色发育异常或进行性白色疾病伴感染。使用结构和代谢成像，我们将确定连接模式的改变是一致的还是可变的，是否可以从这些损伤中恢复，以及这些早期子宫外生活事件是否永久或暂时破坏了连接。数据管理有一个行政核心，包括生物统计支持、预算监督、培训和研讨会。成像和神经行为核心（服务核心）将通过确保方法标准化和在各个测试时间点跟踪成像采集来支持三个人体成像项目。此外，该核心将提供神经行为 在所有随访时进行检测，并负责跟踪所有项目的患者。