Association of Alcohol and Nutrition with Cognition and Brain Structure in Aging

酒精和营养与衰老过程中认知和大脑结构的关系

• 批准号: 8734302
• 负责人: Linda Kathleen McEvoy
• 金额: $ 57.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734302
• 关键词: Address; Adult; Affect; Age; Age-associated memory impairment; Aging; Alcohol Nutrition; Alcohol consumption; Alcohols; Attenuated; Behavior; Behavioral; Biological Markers; Biometry; Body mass index; Brain; Cardiovascular Diseases; Caring; Carotid Atherosclerotic Disease; Characteristics; Cognition; Cognitive; Cognitive aging; Cohort Studies; Communities; Consumption; Data; Databases; Diabetes Mellitus; Diet; Diffusion Magnetic Resonance Imaging; Education; Educational Background; Elderly; Epidemiology; Food; Frequencies; Funding; Health; Image; Impaired cognition; Individual; Inflammatory; Intake; Knowledge; Life Style; Light; Macronutrients Nutrition; Magnetic Resonance Imaging; Maintenance; Measures; Medical; Metabolic; Micronutrients; Moods; Outcome; Participant; Pattern; Peripheral arterial disease; Pharmaceutical Preparations; Physical activity; Physiological; Population; Prevalence; Procedures; Public Health; Quality of life; Questionnaires; Recommendation; Reporting; Risk; Risk Factors; Self-Administered; Smoking; Societies; Stratification; Structure; Testing; Thick; Time; United States National Institutes of Health; Woman; adult nutrition; age related; aging brain; alcohol exposure; cardiovascular disorder risk; cerebral atrophy; cognitive function; cognitive neuroscience; cohort; coronary artery calcification; drinking; economic cost; follow-up; good diet; improved; men; middle age; neuroimaging; nutrition; population based; public health relevance; sex; social; white matter

DESCRIPTION (provided by applicant): With the rapidly growing elderly U.S. population, a better understanding of how alcohol and nutrition interact to protect against or accelerate cognitive decline and age-related brain changes could have profound implications for public health. A large proportion of the adult population regularly consumes alcohol but little is known about how mid and later life alcohol use impacts cognitive function and brain integrity in old age. Even less is known about whether nutrition, which may interact with alcohol at behavioral and physiological levels, influences cognitive function and brain structure. This interdisciplinary proposal, involving experts in epidemiology, cognitive neuroscience, neuroimaging and biostatistics will analyze existing as well as newly collected data from a large, population-based NIH-funded cohort study of older adults, now in its 39th year, the RBS (The Rancho Bernardo Study, RBS; Dr. Barrett-Connor, P.I.). The RBS has an exceptionally rich database for exploring the association of mid and late life alcohol consumption with cognitive function. It contains measures of alcohol intake, including data on frequency, amount and type of alcohol consumed obtained up to 7 times on a given participant over ~25 year period, cognitive function tests assessing different cognitive domains obtained up to 6 times on a given participant over ~20 year follow-up period, and detailed dietary information from up to three administrations of the Harvard Willett Food Frequency questionnaire over ~10 years. It also contains a large number of medical health-related variables, validated medication use, mood and lifestyle measures, which will allow control for numerous potentially confounding covariates and effect modifiers. Analysis of this existing data will allow us to determine how current and prior alcohol use relates to change in cognitive function over time in older adults and how nutrition influences these associations, while controlling for relevant covariates such as education level, smoking, physical activity, medical status (e.g. diabetes, cardiovascular disease), cardiovascular disease risk factors, and medications. We will also collect a comprehensive set of sensitive structural MRI and diffusion tensor imaging (DTI) data, using state-of-the-art image acquisition and analysis procedures, from a subset (n=300) of RBS participants who showed a range of alcohol use at baseline. This will allow us to examine how past and current alcohol use relates to measures of late-life brain structural integrity, and assess whether nutrition modifies these associations, whie controlling for numerous covariates. This study will increase basic knowledge of the association of alcohol and diet on cognitive function and brain health in the elderly, and could result in lifestyle recommendations to promote successful cognitive and brain aging. Because age-related cognitive impairment is a major contributor to loss of independence and lower quality of life in older adults, and because care for cognitively impaired individuals places an enormous financial burden on society, improved understanding of whether and how modifiable behaviors affect cognitive function in aging could have enormous public health impact.

描述（由申请人提供）：随着美国老年人口的迅速增长，更好地了解酒精和营养如何相互作用，以防止或加速认知能力下降和与年龄相关的大脑变化，可能对公共卫生产生深远的影响。很大一部分成年人经常饮酒，但人们对中年和晚年饮酒对老年认知功能和大脑完整性的影响知之甚少。