Development of a Point-of-Care Mass Spectrometry Analysis System
即时质谱分析系统的开发
基本信息
- 批准号:8666779
- 负责人:
- 金额:$ 26.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-01 至 2017-05-31
- 项目状态:已结题
- 来源:
- 关键词:Bedside TestingsBiologicalBiological AssayBloodBlood specimenChemicalsCollaborationsDevelopmentDiagnosisDiseaseDrug MonitoringFutureGeneral PopulationGenerationsGoalsHealthcareIn VitroIonsKnowledgeLaboratoriesLeadMaintenanceMass Spectrum AnalysisMedicalMethodsMiniaturizationMonitorMusNeonatal ScreeningNicotineNursesOutcomeOwnershipPaperPatientsPerformancePharmaceutical PreparationsPhysiciansPlayPoint-of-Care SystemsPreparationProceduresProtocols documentationPublic HealthResearchResearch PersonnelRoleSamplingSeriesSiteSolutionsSystemSystems AnalysisTechnologyTestingTherapeuticTrainingUnited States National Institutes of HealthUniversitiesUniversity of Texas M D Anderson Cancer CenterValidationWorkbaseclinical Diagnosisclinical research sitecostdrug developmentdrug discoveryin vivoinstrumentionizationmass spectrometeroncologyoperationpoint of carepreventpublic health relevanceskillssoftware developmenttechnology developmenttool
项目摘要
DESCRIPTION (provided by applicant): We propose to develop a mass spectrometry (MS) analysis system and a protocol that can be applied for chemical analysis at the point of care (POC) for medical diagnosis. The aims are to develop (1) a miniature mass spectrometer that has compact size, low cost of ownership and maintenance but with adequate performance for quantitative analysis, and (2) sample cartridges for direct analysis of blood samples and (3) an operational protocol that allows this system to be used by nurses and physicians, who do not need to have special training in chemical analysis using MS. This research team at Purdue University has been consistently pushing the development of technologies and applications to allow MS analysis to be used for POC tests at clinical sites and ultimately for personal health care. Our long term goal is to develop a POC MS system and collaborate with researchers such as those at The University of Texas MD Anderson Cancer Center (UTMDACC) to validate the technology and to incorporate it into drug development to optimize disease therapy. The critical issues in the development of a POC MS system have been identified as the miniaturization of the entire analysis system and the simplification of the analysis protocol. In this R01 project, we
propose to develop a complete POC MS analysis system and associated operational protocol based on miniature ion trap and paper spray technologies, and to validate the system for therapeutic drug monitoring with oncology drugs. The expected outcome from the proposed work is the generation of the first POC MS system with a relatively complete solution for therapeutic drug monitoring and with potential for a significant impact on future development of MS-based chemical analysis systems for clinical diagnosis.
描述(由申请人提供):我们建议开发一种质谱(MS)分析系统和一种方案,可用于医疗诊断的护理点(POC)化学分析。目的是开发(1)小型质谱仪,其具有紧凑的尺寸、低的拥有和维护成本,但具有足够的定量分析性能,和(2)用于直接分析血液样品的样品盒,和(3)允许护士和医生使用该系统的操作协议,普渡大学的这个研究小组一直在推动技术和应用的发展,使MS分析能够用于临床研究中心的POC测试,并最终用于个人医疗保健。我们的长期目标是开发POC MS系统,并与德克萨斯大学MD安德森癌症中心(UTMDACC)的研究人员合作,以验证该技术并将其纳入药物开发,以优化疾病治疗。POC MS系统的发展中的关键问题已被确定为整个分析系统的小型化和分析协议的简化。在R01项目中,我们
建议开发一个完整的POC MS分析系统和基于微型离子阱和纸喷雾技术的相关操作协议,并验证该系统用于肿瘤药物的治疗药物监测。拟议工作的预期成果是第一个POC MS系统的产生,该系统具有相对完整的治疗药物监测解决方案,并有可能对未来基于MS的临床诊断化学分析系统的发展产生重大影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Zheng Ouyang其他文献
Zheng Ouyang的其他文献
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{{ truncateString('Zheng Ouyang', 18)}}的其他基金
Development of a Miniature Mass Spectromtry System for Point-of-Care Applications
开发用于现场护理应用的微型质谱系统
- 批准号:
9140342 - 财政年份:2017
- 资助金额:
$ 26.8万 - 项目类别:
Development of a Point-of-Care Mass Spectrometry Analysis System
即时质谱分析系统的开发
- 批准号:
9118271 - 财政年份:2013
- 资助金额:
$ 26.8万 - 项目类别:
Development of a Point-of-Care Mass Spectrometry Analysis System
即时质谱分析系统的开发
- 批准号:
8481745 - 财政年份:2013
- 资助金额:
$ 26.8万 - 项目类别:
Paper Spray Ionization Mass Spectrometry Device for Direct Analysis of Biofluid S
用于直接分析生物流体 S 的纸喷雾电离质谱装置
- 批准号:
8123169 - 财政年份:2010
- 资助金额:
$ 26.8万 - 项目类别:
Paper Spray Ionization Mass Spectrometry Device for Direct Analysis of Biofluid S
用于直接分析生物流体 S 的纸喷雾电离质谱装置
- 批准号:
8269007 - 财政年份:2010
- 资助金额:
$ 26.8万 - 项目类别:
Paper Spray Ionization Mass Spectrometry Device for Direct Analysis of Biofluid S
用于直接分析生物流体 S 的纸喷雾电离质谱装置
- 批准号:
7944793 - 财政年份:2010
- 资助金额:
$ 26.8万 - 项目类别:
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