Environmental Epigenetics on Puberty

青春期的环境表观遗传学

• 批准号: 9048134
• 负责人: FRANK M BIRO
• 金额: $ 41.43万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9048134
• 关键词: Adopted; Adult; Age; Age at Menarche; Behavior; Benchmarking; Biological Phenomena; Body Composition; Body fat; Breast; Community Outreach; Deposition; Development; Dietary intake; Dimensions; Endocrine Disruptors; Endocrine disruption; Energy Intake; Environmental Exposure; Environmental Risk Factor; Epidemiology; Epigenetic Process; Exposure to; Family Study; Fatty acid glycerol esters; Future; Genes; Genetic Polymorphism; Gonadal Steroid Hormones; Growth; Health; Height; Individual; Insulin Resistance; Knowledge; Life Style; Link; Mammary Gland Parenchyma; Mediating; Menarche; Minerals; Morbidity - disease rate; Obesity; Outcome; Participant; Pathway interactions; Physical activity; Phytoestrogens; Predisposition; Prevalence; Prevention strategy; Principal Investigator; Production; Protocols documentation; Puberty; Reporting; Risk; Series; Social Environment; Stress; Teenagers; Time; Toxic Environmental Substances; Visceral; Woman; Work; bone; chemical genetics; cohort; environmental chemical; evidence base; genetic variant; girls; high school; lipid metabolism; malignant breast neoplasm; mortality; obesity risk; outreach program; phthalates; toxicant

Puberty may serve as a window of susceptibility that impacts adult morbidity and mortality, and peripubertal breast tissue may be especially susceptible to environmental exposures. The majority of bone mineral is deposited during teen years, and insulin resistance rises during puberty. Visceral fat is an important factor that increases risk of obesity complications, but little is known about early factors that impact deposition of visceral fat Environmental exposures may impact body composition, as well as pubertal outcomes. Age at menarche is associated with risk of breast cancer, but pubertal growth velocity may be the underlying biologic phenomenon that impacts greater risk of breast cancer in taller women and those with earlier menarche. We will utilize a unique existing cohort of girls followed from ages 6 and 7 and who have had semiannual examinations over 3-5 years. Working closely with the other two BCERC epidemiology projects, and with the Cincinnati BCERC community outreach program, our study proposes to fill the gap towards understanding the relationships between timing of onset and pathway of puberty with menarche, interaction between endocrine disruptors and polymorphisms, and changes in body composition. We will complete the maturation assessment in this established cohort of girls, to include age at menarche, tempo of maturation, age/ value of peak height velocity, body composition and fat distribution, and bone mineral accrual during puberty, by pathway into puberty. We plan to assess dimensions of the physical/social environments including exposures to endocrine disrupting toxicants (EDCs), and how these factors contribute to impact onset of puberty and menarche. We will explore the relationships and interactions of EDCs and genetic polymorphisms, on benchmarks of pubertal maturation. The Cincinnati epidemiology and outreach programs will develop and disseminate materials for lay audiences about lifestyle choices and potential health risks of specific exposures in regard to breast cancer, and enhance protocols to report studyfindingsto study families. This proposal should allow us to understand better how changes during puberty can inform future prevention strategies to decrease the prevalence of breast cancer. RELEVANCE (See instructions): Puberty may serve as a window of susceptibility to adult morbidities and mortality, sucti as breast cancer. This protocol will continue to follow closely a group of girls recruited at ages 6 and 7, studying how the exposure to environmental factors interacts with genetic polymorphisms, and influence factors associated with breast cancer risk.

青春期可能是影响成人发病率和死亡率的易感窗口， 青春期周围的乳房组织可能特别容易受到环境暴露的影响。大部分的骨头 矿物质在青少年时期沉积，胰岛素抵抗在青春期上升。内脏脂肪是一种重要的 增加肥胖并发症风险的因素，但对影响沉积的早期因素知之甚少 环境暴露可能会影响身体成分，以及青春期的结果。年龄 月经初潮与乳腺癌风险相关，但青春期生长速度可能是潜在的生物学因素， 这一现象在较高的女性和初潮较早的女性中影响了更大的乳腺癌风险。 我们将利用一个独特的现有队列的女孩从6岁和7岁，谁有半年一次 3-5年的考试。与其他两个BCERC流行病学项目密切合作， 辛辛那提BCERC社区外展计划，我们的研究提出，以填补差距对理解 发病时间和青春期途径与月经初潮之间的关系，内分泌 干扰物和多态性，以及身体组成的变化。 我们将完成对这个已建立的女孩队列的成熟评估，包括初潮年龄， 成熟克里思、年龄/身高峰值速度值、身体成分和脂肪分布以及骨矿物质 在青春期的积累，通过途径进入青春期。我们计划评估身体/社会 环境，包括暴露于内分泌干扰物（EDCs），以及这些因素如何有助于 影响青春期和月经初潮开始。我们将探讨内分泌干扰物和遗传因子之间的关系和相互作用。 多态性，青春期成熟的基准。辛辛那提的流行病学和外展项目 将为非专业观众制作和传播有关生活方式选择和潜在健康风险的材料， 具体的乳腺癌接触，并加强协议，报告研究结果的研究家庭。 这个建议应该让我们更好地了解青春期的变化如何影响未来的发展。 降低乳腺癌发病率的预防战略。 相关性（参见说明）： 青春期可能是成年人发病率和死亡率（如乳腺癌）易感性的一个窗口。 该议定书将继续密切跟踪一组6岁和7岁被招募的女孩，研究 暴露于环境因素与遗传多态性相互作用， 有患乳腺癌的风险