"Sleep Medicine Neurobiology and Epidemiology"

描述(由申请者提供)：这项培训资助培养睡眠、睡眠生理学和流行病学领域的医生和博士后研究人员，以解决对我们社会的总体健康产生重大影响的问题。科学研究和发现有重大的需求和机会。风险和疾病检测/管理工作发展不足，睡眠医学的基础科学(睡眠生理学和昼夜节律)在生物学、神经网络和脑生理学的功能理解方面存在重大差距，以便为未来的治疗和预防工作提供信息。一个障碍是基础研究和以患者为导向的研究中缺乏研究人员。该项目由退伍军人医学中心睡眠障碍研究中心负责人金曼·P·斯特罗尔负责。睡眠障碍研究中心现在进入了医学院和其他四个克利夫兰学术医疗中心的培训和研究项目。他和一个指导委员会(泰德·迪克博士、理查德·马丁医学博士和马克·钱斯博士)批准进入该项目，并使用形成性学员委员会评估和投资组合技术监控学员的进步。展望未来，增加的维度是物理和生物物理学系正式的系统生物学和生物信息学硕士和博士课程。16名教员导师是“培训者”，4名早期职业获奖者教员是“初级教员”；其他睡眠或基础科学方面的资深教员作为见习委员会成员参加。教员代表六个系，每个系都对睡眠、昼夜生物学、睡眠流行病学和/或临床调查有内在的兴趣。该方案要求两名有足够资源继续深造的研究生实习生和两名研究生实习生。我们为医学博士后实习生提供临床科学(CTST临床研究学者计划)和系统生物学硕士学位课程的选项。对于所有受训者来说，本质是个性化的、有监督的研究培训；但所有受训者都要从事包括睡眠科学和医学、接触其伦理、法律和社区问题以及职业发展在内的教学工作。对于博士前实习生，学位授予部门决定课程工作和论文进度，睡眠医学培训计划的一名临床医生是博士委员会的成员之一。博士后实习生也有一个培训委员会，负责评估进展和指导。所有受训人员都有一系列工作，对进展情况进行自我评估，这是每两年进行一次评估的基础。该小组每周都会举行研讨会，并与外部顾问和教职员工举行年度务虚会。现在，医学、儿科学、生理学和生物物理学、神经科学、计算机科学、生物统计学和流行病学之间存在着强烈的相互作用。睡眠医学项目现在被公认为Case临床转化科学合作研究基础设施的一部分。

DESCRIPTION (provided by applicant): This training grant produces physician and post-doctoral investigators in the fields of sleep, its physiology and epidemiology to address problems that substantially effect the general health of our society. There are significant needs and opportunities for scientific research and discovery. Risk and disease detection/management efforts are poorly developed, and the basic science of sleep medicine (sleep physiology and circadian rhythm) has major gaps in functional understanding of biology, neural networks, and brain physiology in order to inform future treatments and prevention efforts. One barrier is a paucity of investigators in basic- and patient-oriented research. The program is managed by Kingman P. Strohl, who heads the Center for Sleep Disorders Research at the VA Medical Center. The Center for Sleep Disorders Research now reaches training and research programs in the School of Medicine and four other Cleveland academic medical centers. He and a steering committee (Ted Dick, PhD., Richard Martin MD, and Mark Chance PhD) approves admission to the program and monitors trainees' progress using formative trainee committee assessment and portfolio techniques. Looking forward, the added dimension is a formal Systems Biology and Bioinformatics M.S. and Ph.D. curriculum in the Department of Physiology and Biophysics. Sixteen faculty mentors are "trainers", with four early career awardees faculty as "junior trainers"; other senior faculty members in sleep or basic science participate as members of the trainee committee. Faculty represent six departments and each has an inherent interest in sleep, circadian biology, sleep epidemiology, and/or clinical investigation. The program requests two post-graduate trainees with sufficient resources to pursue advanced training and two graduate trainees. We provide options for a Master's Degree programs in Clinical Science (the CTST Clinical Research Scholars Program) and in Systems Biology for MD post-doctoral trainees. For all trainees the essence is individualized, supervised research training; but all trainees meet to engage in didactic work encompassing sleep science and medicine, exposure to its ethical, legal, and community issues, and career development. For pre-doctoral trainees, the degree-granting department determines course work and thesis progress, with a clinician from the Sleep Medicine Training Program as one member of the Ph.D. committee. Post-doctoral trainees also have a training committee which assesses progress and mentorship. All trainees maintain a portfolio of work with self-assessments of progress that forms the basis of bi-annual assessments. There are weekly seminars and an annual retreat of the group with outside advisors and faculty. A strong interaction now occurs among Medicine, Pediatrics, Physiology and Biophysics, Neuroscience, Computer Sciences, and Biostatistics and Epidemiology. The Sleep Medicine program is now a recognized as a part of the Case Clinical Translational Science Collaborative research infrastructure.