Traumatic Brain Injury Across the Lifespan in Uganda Research Initiative

乌干达生命周期中的创伤性脑损伤研究计划

• 批准号: 8991969
• 负责人: ADNAN A HYDER
• 金额: $ 19.64万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8991969
• 关键词: Address; Africa; Africa South of the Sahara; Brain Diseases; Cause of Death; Clinical; Collaborations; Common Data Element; Consultations; Country; Data; Data Analyses; Data Collection; Data Element; Development; Economic Burden; Educational Curriculum; Educational process of instructing; Educational workshop; Epidemiology; Evaluation; Factor Analysis; Faculty; Future; Generations; Goals; Health; Health Policy; Hospital Referrals; Hospitals; Human Resources; Incidence; Income; Information Systems; Information Technology; Injury; Institution; Internet; Intervention; Intervention Studies; Joints; Knowledge; Literature; Longevity; Measures; Mentors; Modeling; National Institute of Neurological Disorders and Stroke; Nature; Neurosurgeon; Outcome; Patients; Peer Review; Population; Prevention; Preventive; Public Health; Public Health Schools; Public Sector; Recording of previous events; Registries; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Risk; Risk Factors; Running; Seasonal Variations; Secure; Severities; Surgeon; System; Testing; Training; Trauma; Traumatic Brain Injury; Uganda; United States National Institutes of Health; Universities; Violence; Vulnerable Populations; Work; World Health Organization; base; burden of illness; clinical care; data registry; design; disability; experience; health economics; improved; injury burden; innovation; mortality; programs; prospective; public health relevance; rat Ran 2 protein; response; skills; systematic review

 DESCRIPTION (provided by applicant): Each year, it is estimated that more than 10 million people in the world suffer Traumatic Brain Injury (TBI), and in sub-Saharan Africa TBI rates are much higher than global averages. Rates of TBI mortality and disability in Uganda are similar to those throughout SSA, yet national data on the burden of injury are scarce. The large and growing burden of TBI in Uganda urgently requires a response, which in turn will require that critical knowledge gaps be addressed. We propose the Traumatic Brain Injury Across the Lifespan in Uganda (TBI-Uganda) Program to define the health and economic burden of traumatic brain injuries across the lifespan in Uganda in a collaborative research effort that will define the burden of TBI, develop sustainable data systems, and train Ugandans in TBI research to help find and fill these gaps and advance a research-based response. Our innovative model of sustainable research collaboration will involve the Johns Hopkins University Bloomberg School of Public Health (JHU), USA and Makerere University School of Public Health (MU) and Mulago National Referral Hospital (MH) in Uganda. We will use US expertise to strengthen the Ugandan institutions, promote a sustainable research enterprise focused on TBI, and enable further use of research evidence by proposing a larger intervention study in Uganda. The project's research will identify gaps in public health expertise and in clinical care o TBI patients. We will apply these results to reduce the growing burden of TBI across the lifespan and propose a larger intervention study by the end of two years. We will first define core variables and Internet platforms for a data registry focused on traumatic brain injuries in Uganda (Specific Aim 1, months 1-6). We will then pilot-test the Internet-based the Kampala internet-Traumatic Brain Injury Registry (KiTBIR) registry at MH for 1 year (Specific Aim 2, months 7-18). This not only will improve understanding of TBI in Kampala, but also will test the viability of ongoing data systems and human resources support for such a secure internet-based registry, because continuous data collection system will be crucial to the design and evaluation of future interventions. Throughout the project we will develop research skills and data analysis capacity among a core group of TBI clinicians at MH and MU (Specific Aim 3, months 1-24), through researcher and stakeholder workshops as well as online courses in relevant health and policy topics. Finally, we will develop a research plan for an intervention study on TBI in Kampala as a joint JHU-MU proposal (R01) for research to evaluate a set of interventions using the KiTBIR (Specific Aim 4, months 20-24). Implementation of a TBI registry at MH will help clearly define the burden of TBI in Uganda and the risk factors associated with TBI incidence and outcome, and help identify correctable factors in the treatment of this population. The Internet-based approach to TBI registry development outlined in this proposal represents a significant advancement in data collection for TBI patients in the developing world.

 描述（由申请人提供）：据估计，全球每年有超过 1000 万人遭受创伤性脑损伤 (TBI)，而撒哈拉以南非洲地区的 TBI 发生率远高于全球平均水平。乌干达的 TBI 死亡率和残疾率与整个 SSA 相似，但有关伤害负担的国家数据却很少。乌干达创伤性脑损伤造成的巨大且日益严重的负担迫切需要采取应对措施，而这反过来又需要解决关键的知识差距。我们提出乌干达终生创伤性脑损伤（TBI-乌干达）计划，通过一项合作研究工作来确定乌干达终生创伤性脑损伤的健康和经济负担，该项目将 确定 TBI 的负担，开发可持续的数据系统，并对乌干达人进行 TBI 研究培训，以帮助发现和填补这些空白，并推进基于研究的应对措施。我们可持续研究合作的创新模式将涉及美国约翰霍普金斯大学彭博公共卫生学院 (JHU) 和乌干达马凯雷雷大学公共卫生学院 (MU) 和穆拉戈国家转诊医院 (MH)。我们将利用美国的专业知识来加强乌干达的机构，促进专注于 TBI 的可持续研究事业，并通过提议在乌干达进行更大规模的干预研究来进一步利用研究证据。该项目的研究将确定公共卫生专业知识和 TBI 患者临床护理方面的差距。我们将应用这些结果来减轻 TBI 在整个生命周期中日益增加的负担，并在两年结束前提出一项更大规模的干预研究。我们将首先为乌干达脑外伤数据登记定义核心变量和互联网平台（具体目标 1，第 1-6 个月）。然后，我们将在 MH 基于互联网的坎帕拉互联网创伤性脑损伤登记处 (KiTBIR) 登记处进行为期 1 年的试点测试（具体目标 2，第 7-18 个月）。这不仅将增进对坎帕拉 TBI 的了解，还将测试持续数据系统的可行性以及对基于互联网的安全登记系统的人力资源支持，因为持续数据收集系统对于未来干预措施的设计和评估至关重要。在整个项目中，我们将通过研究人员和利益相关者研讨会以及相关健康和政策主题的在线课程，培养 MH 和 MU 的 TBI 临床医生核心小组的研究技能和数据分析能力（具体目标 3，第 1-24 个月）。最后，我们将为坎帕拉的 TBI 干预研究制定一项研究计划，作为 JHU-MU 联合提案 (R01)，用于研究评估使用 KiTBIR 的一组干预措施（具体目标 4，第 20-24 个月）。在 MH 实施 TBI 登记将有助于明确乌干达 TBI 的负担以及与 TBI 发生率和结果相关的危险因素，并有助于确定该人群治疗中的可纠正因素。本提案中概述的基于互联网的 TBI 登记开发方法代表了发展中国家 TBI 患者数据收集方面的重大进步。