Traumatic Brain Injury Across the Lifespan in Uganda Research Initiative

乌干达生命周期中的创伤性脑损伤研究计划

• 批准号: 8991969
• 负责人: ADNAN A HYDER
• 金额: $ 19.64万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8991969
• 关键词: Address; Africa; Africa South of the Sahara; Brain Diseases; Cause of Death; Clinical; Collaborations; Common Data Element; Consultations; Country; Data; Data Analyses; Data Collection; Data Element; Development; Economic Burden; Educational Curriculum; Educational process of instructing; Educational workshop; Epidemiology; Evaluation; Factor Analysis; Faculty; Future; Generations; Goals; Health; Health Policy; Hospital Referrals; Hospitals; Human Resources; Incidence; Income; Information Systems; Information Technology; Injury; Institution; Internet; Intervention; Intervention Studies; Joints; Knowledge; Literature; Longevity; Measures; Mentors; Modeling; National Institute of Neurological Disorders and Stroke; Nature; Neurosurgeon; Outcome; Patients; Peer Review; Population; Prevention; Preventive; Public Health; Public Health Schools; Public Sector; Recording of previous events; Registries; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Risk; Risk Factors; Running; Seasonal Variations; Secure; Severities; Surgeon; System; Testing; Training; Trauma; Traumatic Brain Injury; Uganda; United States National Institutes of Health; Universities; Violence; Vulnerable Populations; Work; World Health Organization; base; burden of illness; clinical care; data registry; design; disability; experience; health economics; improved; injury burden; innovation; mortality; programs; prospective; public health relevance; rat Ran 2 protein; response; skills; systematic review

 DESCRIPTION (provided by applicant): Each year, it is estimated that more than 10 million people in the world suffer Traumatic Brain Injury (TBI), and in sub-Saharan Africa TBI rates are much higher than global averages. Rates of TBI mortality and disability in Uganda are similar to those throughout SSA, yet national data on the burden of injury are scarce. The large and growing burden of TBI in Uganda urgently requires a response, which in turn will require that critical knowledge gaps be addressed. We propose the Traumatic Brain Injury Across the Lifespan in Uganda (TBI-Uganda) Program to define the health and economic burden of traumatic brain injuries across the lifespan in Uganda in a collaborative research effort that will define the burden of TBI, develop sustainable data systems, and train Ugandans in TBI research to help find and fill these gaps and advance a research-based response. Our innovative model of sustainable research collaboration will involve the Johns Hopkins University Bloomberg School of Public Health (JHU), USA and Makerere University School of Public Health (MU) and Mulago National Referral Hospital (MH) in Uganda. We will use US expertise to strengthen the Ugandan institutions, promote a sustainable research enterprise focused on TBI, and enable further use of research evidence by proposing a larger intervention study in Uganda. The project's research will identify gaps in public health expertise and in clinical care o TBI patients. We will apply these results to reduce the growing burden of TBI across the lifespan and propose a larger intervention study by the end of two years. We will first define core variables and Internet platforms for a data registry focused on traumatic brain injuries in Uganda (Specific Aim 1, months 1-6). We will then pilot-test the Internet-based the Kampala internet-Traumatic Brain Injury Registry (KiTBIR) registry at MH for 1 year (Specific Aim 2, months 7-18). This not only will improve understanding of TBI in Kampala, but also will test the viability of ongoing data systems and human resources support for such a secure internet-based registry, because continuous data collection system will be crucial to the design and evaluation of future interventions. Throughout the project we will develop research skills and data analysis capacity among a core group of TBI clinicians at MH and MU (Specific Aim 3, months 1-24), through researcher and stakeholder workshops as well as online courses in relevant health and policy topics. Finally, we will develop a research plan for an intervention study on TBI in Kampala as a joint JHU-MU proposal (R01) for research to evaluate a set of interventions using the KiTBIR (Specific Aim 4, months 20-24). Implementation of a TBI registry at MH will help clearly define the burden of TBI in Uganda and the risk factors associated with TBI incidence and outcome, and help identify correctable factors in the treatment of this population. The Internet-based approach to TBI registry development outlined in this proposal represents a significant advancement in data collection for TBI patients in the developing world.