Traumatic Brain Injury Across the Lifespan in Zambia

项目概要/摘要 赞比亚终生创伤性脑损伤（TBI-Zambia）计划的总体目标是 以确定赞比亚人一生中创伤性脑损伤的健康和经济负担。我们将尽 通过建立创伤性脑损伤电子登记册（脑 卢萨卡损伤登记处（BraiL））收集大学教学医院所有TBI的数据。我们 方法将涉及米尔肯研究所公共卫生学院，乔治 美国华盛顿大学、赞比亚大学公共卫生学院及其大学 赞比亚卢萨卡教学医院。GW和UNZA共同致力于研究 培训，在伤害和卫生服务研究中应用电子登记的专门知识，以及 富有成效的合作历史。UNZA和UTH共同致力于提供最高质量的 为赞比亚的贫困社区提供服务，并重点优化低资源社区的成果。 设置.我们的建议将利用共同的兴趣，了解创伤和大脑的影响， 并加强研究能力，解决在解决这些健康问题方面的两个关键差距 - 创建关于创伤性脑损伤的国家分类数据，确定其风险和弱势群体，以及 潜在的干预措施，并发展一个具有研究和数据管理技能的临床医生核心小组。我们 TBI-Zambia合作将有助于加强UNZA/UTH和赞比亚的能力， 其他医疗保健领域的方法。本建议的具体目标是：（1）界定核心 赞比亚创伤性脑损伤数据登记的变量和数字平台;（2）试点测试 赞比亚大学教学医院的数字创伤性脑损伤登记处，为期一年;以及（3） 在大学教学中培养具有研究技能和数据分析能力的临床医生核心团队 赞比亚大学医院。我们将应用研究结果来减轻TBI日益增长的负担 并在两年后提出一项更大规模的干预研究。 以TBI患者为重点，我们将开发数字登记，并将在外科手术中实施。 UTH的急诊室（接收所有创伤患者，进行评估和治疗）。 脑损伤的流行病学信息，TBI的发生、性质、类型和结局，包括风险 将通过12个月的前瞻性数据收集过程收集因素分析和季节变化。 这些数据对于评估未来的干预措施和提出政策建议至关重要。加强 为了应对TBI，我们将发展临床医生（外科医生，创伤外科医生， 通过现场实践培训、短期讲习班和在线课程，在赞比亚培训神经外科医生。

Project Summary/Abstract The overall goal of the Traumatic Brain Injury Across the Lifespan in Zambia (TBI-Zambia) program is to define the health and economic burden of traumatic brain injuries across the lifespan in Zambia. We will do this by strengthening the local data infrastructure with an electronic registry on traumatic brain injuries (Brain Injury Registry of Lusaka (BraiL)) to collect data on all TBI seen at the University Teaching Hospital. Our approach will involve close collaboration between Milken Institute School of Public Health, the George Washington University (GW), USA, the University of Zambia School of Public Health (UNZA) and its University Teaching Hospital (UTH), Lusaka, Zambia. GW and UNZA share a documented commitment to research training, expertise in application of electronic registries in injuries and health services research, as well as a history of productive collaborative work. UNZA and UTH share a commitment to providing the highest quality service to the under-privileged communities in Zambia, and focus on optimizing outcomes in low-resource settings. Our proposal will leverage the shared interest in understanding the impact of trauma and brain disorders and strengthening research capacity and tackle two critical gaps in addressing these health concerns – create national, disaggregated data on TBI, define their risks and vulnerable groups and the impact of potential interventions and develop a core group of clinicians with research and data management skills. Our TBI-Zambia collaboration will help strengthen capacity within UNZA/UTH and Zambia to apply these methodologies to other areas of health care. The specific aims of this proposal are: (1) To Define core variables and digital platforms for a data registry focused on traumatic brain injuries in Zambia; (2) To Pilot-test a digital traumatic brain injury registry at University Teaching Hospital, University of Zambia for a year; and (3) To Develop a core group of clinicians with research skills and data analysis capacity at University Teaching Hospital, University of Zambia. We will apply the results of the study to reduce the growing burden of TBI across the lifespan and propose a larger intervention study by the end of two years. With TBI patients as our focus, we will develop digital registry, which will be implemented in the Surgical Emergency Unit (where all trauma patients are received, assessed and treatment is initiated) of UTH. Information on the epidemiology of the brain injury, occurrence, nature, type and outcomes of TBI including risk factor analysis and seasonal variation will be collected through 12-month prospective data collection process. The data will be crucial for evaluating future interventions and outlining policy recommendations. To strengthen the response to TBI, we will develop research capacity among clinicians (surgeons, trauma surgeons, neurosurgeons) in Zambia through hand-on onsite training, short-term workshops and online courses.