Pathology of Aging Research Network

衰老病理学研究网络

• 批准号: 8665573
• 负责人: Warren C LADIGES
• 金额: $ 36.63万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665573
• 关键词: Address; Affect; Age; Aging; Animals; Cardiac; Cessation of life; Chronic; Cognition; Data; Data Analyses; Development; Discipline; Disease; Environment; Experimental Designs; Funding; Gerontology; Goals; Health; Histologic; Human; Individual; Intervention; Investments; Knowledge; Learning; Lesion; Life; Longevity; Methods; Mission; Mus; Outcome; Pathologic; Pathologist; Pathology; Physiological; Prevention; Principal Investigator; Procedures; Process; Public Health; Research; Research Design; Resources; Scientist; Series; Severities; Shock; Sorting - Cell Movement; Survival Rate; Testing; Time; Tissues; Training; United States National Institutes of Health; Universities; Update; Washington; Work; animal colony; base; body system; design; disability; empowerment; functional decline; innovation; insight; interest; muscle strength; neoplastic; programs; public health relevance; senescence; symposium

DESCRIPTION (provided by applicant): Experimental design for mouse aging studies has historically involved lifespan, but it is now clear that survival data without pathologic data limis the information that can be obtained on aging animals. This limitation becomes more serious when interventions of any sort are implemented. Pathology gives an insight into the health of an animal by revealing lesions not readily observable in the live animal. As such, it is a snapshot of disease conditions at the time of death. Therefore, the long term goal is to establish pathologic information as an essential component of studies involving aging animals. Given that pathologic assessment is essential to help define the progression of lesions associated with aging, the real challenge is including it in aging studies because there is currently a lack of specialized expertise and resources. The objective of this application is to increase the level and scope of pathologic assessment of tissues from old mice involved in aging studies using a core network of pathologists and scientists with expertise in the pathology of aging. The rationale for the proposed work is that the expertise and methods for assessing aging pathology are critically lacking and as such impose major limitations on gathering essential information from aging studies. We plan to attain the objective of this application by pursuing two specific aims. Aim 1 i designed to provide an environment to promote learning and exchange of scientific information for pathologists and other scientists in aging pathology research through a series of pathology of aging online research symposia. The symposia will also be a venue for presenting updates on progress on the development of uniform ways of integrating pathology into aging studies of mice as described in Aim 2. Aim 2 will focus on the correlation of pathology data with longitudinal and cross-sectional lifespan data and physiologic data by enhancing standard histologic assessment of lesions observed in tissues from old mice. There will be one-week hands- on training sessions for selected individual trainees. The approach is innovative because it is based on the concept that pathologic assessment can be promoted by a series of online research symposia conducted by expert pathologists and scientists with a focus on new information and exchange of scientific ideas related to pathology of aging. The proposal is significant because it will provide an environment for the development and integration of pathology data into aging studies of mice, encourage more pathologists and other scientists to specialize in pathology of aging, and establish relevant standards to compare with other species including humans. Such results would be expected to have an important positive impact on aging studies because of the significant empowerment on data analyses and interpretation.

描述（由申请人提供）：小鼠衰老研究的实验设计历来涉及寿命，但现在很清楚，没有病理学数据的存活数据限制了可以从衰老动物中获得的信息。在采取任何形式的干预措施时，这一限制就变得更加严重。病理学通过揭示在活体动物中不易观察到的病变来深入了解动物的健康状况。因此，这是一个快照， 死亡时的病情。因此，长期目标是建立病理信息作为涉及老龄动物的研究的重要组成部分。鉴于病理评估对于帮助确定与衰老相关的病变进展至关重要，真实的挑战是将其纳入衰老研究，因为目前缺乏专业知识和资源。本申请的目的是使用具有衰老病理学专业知识的病理学家和科学家的核心网络，提高衰老研究中涉及的老年小鼠组织的病理学评估水平和范围。拟议工作的理由是，评估衰老病理学的专业知识和方法严重缺乏，因此对从衰老研究中收集必要信息施加了重大限制。我们计划通过追求两个具体目标来实现本申请的目标。目的1通过一系列的衰老病理学在线研究研讨会，为病理学家和其他衰老病理学研究科学家提供一个促进学习和科学信息交流的环境。研讨会也将是一个场所，介绍有关将病理学整合到目标2所述小鼠衰老研究中的统一方法的发展进展。目标2将集中于病理学数据与纵向和横截面寿命数据和生理数据的相关性，通过增强对老年小鼠组织中观察到的病变的标准组织学评估。将为选定的个别学员举办为期一周的实践培训班。该方法是创新的，因为它是基于这样的概念，即病理评估可以通过由专家病理学家和科学家进行的一系列在线研究研讨会来促进，重点是与衰老病理学相关的新信息和科学思想的交流。该提案意义重大，因为它将为病理学数据的开发和整合提供一个环境，鼓励更多的病理学家和其他科学家专注于衰老病理学，并建立相关标准与包括人类在内的其他物种进行比较。这些结果预计将对老龄化研究产生重要的积极影响，因为数据分析和解释的显着授权。