Pathology of Aging Research Network

衰老病理学研究网络

基本信息

批准号：
8846003
负责人：
Warren C LADIGES
金额：
$ 37.47万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-15 至 2017-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Experimental design for mouse aging studies has historically involved lifespan, but it is now clear that survival data without pathologic data limis the information that can be obtained on aging animals. This limitation becomes more serious when interventions of any sort are implemented. Pathology gives an insight into the health of an animal by revealing lesions not readily observable in the live animal. As such, it is a snapshot of disease conditions at the time of death. Therefore, the long term goal is to establish pathologic information as an essential component of studies involving aging animals. Given that pathologic assessment is essential to help define the progression of lesions associated with aging, the real challenge is including it in aging studies because there is currently a lack of specialized expertise and resources. The objective of this application is to increase the level and scope of pathologic assessment of tissues from old mice involved in aging studies using a core network of pathologists and scientists with expertise in the pathology of aging. The rationale for the proposed work is that the expertise and methods for assessing aging pathology are critically lacking and as such impose major limitations on gathering essential information from aging studies. We plan to attain the objective of this application by pursuing two specific aims. Aim 1 i designed to provide an environment to promote learning and exchange of scientific information for pathologists and other scientists in aging pathology research through a series of pathology of aging online research symposia. The symposia will also be a venue for presenting updates on progress on the development of uniform ways of integrating pathology into aging studies of mice as described in Aim 2. Aim 2 will focus on the correlation of pathology data with longitudinal and cross-sectional lifespan data and physiologic data by enhancing standard histologic assessment of lesions observed in tissues from old mice. There will be one-week hands- on training sessions for selected individual trainees. The approach is innovative because it is based on the concept that pathologic assessment can be promoted by a series of online research symposia conducted by expert pathologists and scientists with a focus on new information and exchange of scientific ideas related to pathology of aging. The proposal is significant because it will provide an environment for the development and integration of pathology data into aging studies of mice, encourage more pathologists and other scientists to specialize in pathology of aging, and establish relevant standards to compare with other species including humans. Such results would be expected to have an important positive impact on aging studies because of the significant empowerment on data analyses and interpretation.

描述（由申请人提供）：小鼠老化研究的实验设计历史上涉及寿命，但是现在很明显，没有病理数据的生存数据limis limis可以获得有关衰老动物的信息。当实施任何形式的干预措施时，这种限制变得更加严重。病理学通过揭示了活动物中不容易观察到的病变来深入了解动物的健康。因此，它是死亡时的疾病状况。因此，长期目标是将病理信息建立为涉及衰老动物的研究的重要组成部分。鉴于病理评估对于帮助定义与衰老相关的病变的进展至关重要，因此真正的挑战在于衰老研究中，因为目前缺乏专业专业知识和资源。该应用的目的是提高使用病理学家和科学家的核心研究网络和具有专业知识在衰老病理学方面的专业知识的核心研究网络的老鼠的病理评估的水平和范围。拟议工作的理由是，评估老化病理学的专业知识和方法严重缺乏，因此对从衰老研究中收集基本信息施加了主要局限性。我们计划通过追求两个具体目标来实现本申请的目标。 AIM 1我旨在提供一个环境，以通过一系列衰老的在线研究研讨会的病理学来促进病理学家和其他科学家的科学信息的学习和交流。该研讨会还将成为一个场所，以介绍有关将病理学融合到小鼠衰老研究的进度的最新信息。如AIM 2中所述。AIM2将重点关注病理数据的相关性，以及通过在组织中观察到的老年lies的les液的纵向和生理数据的纵向和生理数据的纵向和生理数据的相关性。将为选定的单个学员进行一周的培训课程。这种方法具有创新性，因为它基于这样的概念，即病理评估可以通过专家病理学家和科学家进行的一系列在线研究研讨会来促进，并着重于新信息和与衰老病理学有关的科学思想的交流。该提案很重要，因为它将为将病理数据的发展和整合到小鼠的衰老研究，鼓励更多的病理学家和其他科学家专门研究衰老的病理学，并建立相关标准以与其他物种（包括人类在内的其他物种）进行比较。由于对数据分析和解释的重大授权，因此预计此类结果将对衰老研究产生重要的积极影响。