Pathology of Aging Research Network

描述(由申请人提供)：小鼠衰老研究的实验设计历史上涉及寿命，但现在很明显，没有病理数据的生存数据限制了可以获得的关于衰老动物的信息。当实施任何类型的干预时，这一限制变得更加严重。病理学通过揭示活体动物中不易观察到的损伤来洞察动物的健康状况。因此，这是一个快照 死亡时的疾病状况。因此，长期目标是将病理信息作为涉及老龄动物的研究的重要组成部分。鉴于病理评估对于帮助确定与衰老相关的病变进展至关重要，真正的挑战是将其纳入老龄研究，因为目前缺乏专门的专业知识和资源。这项应用的目的是利用在衰老病理学方面具有专业知识的病理学家和科学家的核心网络，提高参与衰老研究的老年小鼠组织的病理评估的水平和范围。拟议工作的理由是，严重缺乏评估衰老病理学的专业知识和方法，因此在从衰老研究中收集基本信息方面存在重大限制。我们计划通过追求两个具体目标来实现这一应用程序的目标。目的1通过一系列老龄病理学在线研究研讨会，为老年病理学研究中的病理学家和其他科学家提供一个促进学习和科学信息交流的环境。研讨会还将介绍在发展统一的方法将病理学纳入小鼠衰老研究方面的最新进展，如目标2所述。目标2将通过加强对老年小鼠组织中观察到的损伤的标准组织学评估，集中于病理数据与纵向和横截面寿命数据和生理数据的相关性。将为选定的个别学员提供为期一周的实践培训课程。这种方法是创新的，因为它基于这样的概念，即可以通过由专家病理学家和科学家举办的一系列在线研究研讨会来促进病理评估，重点是与衰老病理学相关的新信息和科学思想交流。这项建议意义重大，因为它将为病理学数据的开发和整合提供环境，将其纳入小鼠的衰老研究，鼓励更多的病理学家和其他科学家专门研究衰老的病理学，并建立相关标准，以与包括人类在内的其他物种进行比较。这些结果预计将对老龄化研究产生重要的积极影响，因为这大大增强了数据分析和解释的能力。

DESCRIPTION (provided by applicant): Experimental design for mouse aging studies has historically involved lifespan, but it is now clear that survival data without pathologic data limis the information that can be obtained on aging animals. This limitation becomes more serious when interventions of any sort are implemented. Pathology gives an insight into the health of an animal by revealing lesions not readily observable in the live animal. As such, it is a snapshot of disease conditions at the time of death. Therefore, the long term goal is to establish pathologic information as an essential component of studies involving aging animals. Given that pathologic assessment is essential to help define the progression of lesions associated with aging, the real challenge is including it in aging studies because there is currently a lack of specialized expertise and resources. The objective of this application is to increase the level and scope of pathologic assessment of tissues from old mice involved in aging studies using a core network of pathologists and scientists with expertise in the pathology of aging. The rationale for the proposed work is that the expertise and methods for assessing aging pathology are critically lacking and as such impose major limitations on gathering essential information from aging studies. We plan to attain the objective of this application by pursuing two specific aims. Aim 1 i designed to provide an environment to promote learning and exchange of scientific information for pathologists and other scientists in aging pathology research through a series of pathology of aging online research symposia. The symposia will also be a venue for presenting updates on progress on the development of uniform ways of integrating pathology into aging studies of mice as described in Aim 2. Aim 2 will focus on the correlation of pathology data with longitudinal and cross-sectional lifespan data and physiologic data by enhancing standard histologic assessment of lesions observed in tissues from old mice. There will be one-week hands- on training sessions for selected individual trainees. The approach is innovative because it is based on the concept that pathologic assessment can be promoted by a series of online research symposia conducted by expert pathologists and scientists with a focus on new information and exchange of scientific ideas related to pathology of aging. The proposal is significant because it will provide an environment for the development and integration of pathology data into aging studies of mice, encourage more pathologists and other scientists to specialize in pathology of aging, and establish relevant standards to compare with other species including humans. Such results would be expected to have an important positive impact on aging studies because of the significant empowerment on data analyses and interpretation.