Pathology of Aging Research Network

衰老病理学研究网络

基本信息

  • 批准号:
    9063461
  • 负责人:
  • 金额:
    $ 38.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-05-15 至 2018-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Experimental design for mouse aging studies has historically involved lifespan, but it is now clear that survival data without pathologic data limis the information that can be obtained on aging animals. This limitation becomes more serious when interventions of any sort are implemented. Pathology gives an insight into the health of an animal by revealing lesions not readily observable in the live animal. As such, it is a snapshot of disease conditions at the time of death. Therefore, the long term goal is to establish pathologic information as an essential component of studies involving aging animals. Given that pathologic assessment is essential to help define the progression of lesions associated with aging, the real challenge is including it in aging studies because there is currently a lack of specialized expertise and resources. The objective of this application is to increase the level and scope of pathologic assessment of tissues from old mice involved in aging studies using a core network of pathologists and scientists with expertise in the pathology of aging. The rationale for the proposed work is that the expertise and methods for assessing aging pathology are critically lacking and as such impose major limitations on gathering essential information from aging studies. We plan to attain the objective of this application by pursuing two specific aims. Aim 1 i designed to provide an environment to promote learning and exchange of scientific information for pathologists and other scientists in aging pathology research through a series of pathology of aging online research symposia. The symposia will also be a venue for presenting updates on progress on the development of uniform ways of integrating pathology into aging studies of mice as described in Aim 2. Aim 2 will focus on the correlation of pathology data with longitudinal and cross-sectional lifespan data and physiologic data by enhancing standard histologic assessment of lesions observed in tissues from old mice. There will be one-week hands- on training sessions for selected individual trainees. The approach is innovative because it is based on the concept that pathologic assessment can be promoted by a series of online research symposia conducted by expert pathologists and scientists with a focus on new information and exchange of scientific ideas related to pathology of aging. The proposal is significant because it will provide an environment for the development and integration of pathology data into aging studies of mice, encourage more pathologists and other scientists to specialize in pathology of aging, and establish relevant standards to compare with other species including humans. Such results would be expected to have an important positive impact on aging studies because of the significant empowerment on data analyses and interpretation.
描述(由申请人提供):小鼠衰老研究的实验设计历来涉及寿命,但现在很清楚,没有病理数据的生存数据限制了可以获得的衰老动物信息。当实施任何形式的干预措施时,这种限制变得更加严重。病理学通过揭示在活的动物中不易观察到的病变来洞察动物的健康状况。因此,它是一个快照

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The geropathology of organ-specific aging.
器官特异性衰老的老年病理学。
  • DOI:
    10.15761/jts.1000458
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Klug,Jenna;Christensen,Sara;Imai,DeniseM;Snider,TimothyA;Ladiges,Warren
  • 通讯作者:
    Ladiges,Warren
Geropathology. An inside view of biological aging.
The unrecognized potential of pet cats for studying aging and age-related diseases.
Grip strength is potentially an early indicator of age-related decline in mice.
握力强度可能是小鼠与年龄相关的早期指标。
The potential use of physical resilience to predict healthy aging.
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Warren C LADIGES其他文献

Warren C LADIGES的其他文献

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{{ truncateString('Warren C LADIGES', 18)}}的其他基金

Physical resilience is a predictor of healthy aging
身体弹性是健康衰老的预测指标
  • 批准号:
    10731992
  • 财政年份:
    2017
  • 资助金额:
    $ 38.63万
  • 项目类别:
Physical resilience is a predictor of healthy aging in mice
身体恢复能力是小鼠健康衰老的预测因素
  • 批准号:
    9418968
  • 财政年份:
    2017
  • 资助金额:
    $ 38.63万
  • 项目类别:
Physical resilience is a predictor of healthy aging in mice
身体恢复能力是小鼠健康衰老的预测因素
  • 批准号:
    10166752
  • 财政年份:
    2017
  • 资助金额:
    $ 38.63万
  • 项目类别:
Pathology of Aging Research Network
衰老病理学研究网络
  • 批准号:
    8665573
  • 财政年份:
    2014
  • 资助金额:
    $ 38.63万
  • 项目类别:
Pathology of Aging Research Network
衰老病理学研究网络
  • 批准号:
    8846003
  • 财政年份:
    2014
  • 资助金额:
    $ 38.63万
  • 项目类别:
Mitochondrial catalase as a treatment for metastatic breast cancer
线粒体过氧化氢酶治疗转移性乳腺癌
  • 批准号:
    7707170
  • 财政年份:
    2009
  • 资助金额:
    $ 38.63万
  • 项目类别:
Cancer susceptibility of XRCC1 mutant mice
XRCC1突变小鼠的癌症易感性
  • 批准号:
    7439285
  • 财政年份:
    2008
  • 资助金额:
    $ 38.63万
  • 项目类别:
Cancer susceptibility of XRCC1 mutant mice
XRCC1突变小鼠的癌症易感性
  • 批准号:
    7609207
  • 财政年份:
    2008
  • 资助金额:
    $ 38.63万
  • 项目类别:
CORE--Transgenic Animal Support
核心——转基因动物支持
  • 批准号:
    6880488
  • 财政年份:
    2005
  • 资助金额:
    $ 38.63万
  • 项目类别:
Alzheimer's Disease and Impaired APP Proteolysis
阿尔茨海默病和 APP 蛋白水解受损
  • 批准号:
    7140287
  • 财政年份:
    2005
  • 资助金额:
    $ 38.63万
  • 项目类别:

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