Macaque Resources

猕猴资源

• 批准号: 8913419
• 负责人: Louis J. Picker
• 金额: $ 51.18万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8913419
• 关键词: Acquired Immunodeficiency Syndrome; Animal Model; Animals; Cellular Immunology; Complex; Disease; HIV; HIV Infections; HIV vaccine; Human; Immune system; Immunity; Macaca; Macaca mulatta; Modeling; Research; Research Infrastructure; Resources; SIV; Vaccination; Vaccine Design; Vaccine Research; neutralizing antibody; nonhuman primate; pre-clinical; programs; simian human immunodeficiency virus; vaccine development

The Indian rhesus macaque develops a disease that closely mimics human acquired immunodeficiency syndrome (AIDS) when infected by simian immunodeficiency virus (SIV) or chimeric simian-human immunodeficiency viruses (SHIV), and represents the best animal model for HIV infection. Because of the similarity of the immune systems of macaques and humans, preclinical vaccine development is heavily dependent on the SIV and SHIV macaque models. Their research value notwithstanding, nonhuman primates (NHPs) are complex, higher order species that require specialized infrastructure and expertise in a research setting. The NHP Core seeks to consolidate the experimental animal and cellular immunology portions of the HIV Vaccine Research and Design (HIVRAD) Program project,

印度恒河猴患上一种与人类获得性免疫缺陷非常相似的疾病 感染猴免疫缺陷病毒(SIV)或嵌合猴-人类时的综合征(艾滋病) 免疫缺陷病毒(SIV)，代表了HIV感染的最佳动物模型。因为 由于猕猴和人类的免疫系统相似，临床前疫苗的开发工作进展缓慢 依赖于SIV和SHIV猕猴模型。尽管它们具有研究价值，但非人类 灵长类(NHP)是复杂的高级物种，需要专门的基础设施和专业知识 研究背景。NHP核心致力于巩固实验动物和细胞免疫学 HIV疫苗研究和设计(HIVRAD)计划项目的部分内容，